Motoric cognitive risk syndrome: Integration of two early harbingers of dementia in older adults

Semba, Richard D.; Tian, Qu; Carlson, Michelle C.; Qin, Xue; Ferrucci, Luigi

doi:10.1016/j.arr.2020.101022

Cited by 60 publications

(107 citation statements)

References 268 publications

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“…We adopted the 3IR test of MMSE instead of SCCs for definition of MCR based on the following reasons. First, most previous studies identified SCCs using memory-related items [22]. Therefore, we intended to find another tool to represent the subjects' memory function.…”

Section: Discussionmentioning

confidence: 99%

Motoric Cognitive Risk Syndrome Using Three-Item Recall Test and Its Associations with Fall-Related Outcomes: The Korean Frailty and Aging Cohort Study

Shim

Kim

Won

2020

IJERPH

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Motoric cognitive risk (MCR) syndrome is originally defined as the presence of subjective cognitive complaints (SCCs) and slow gait (SG). MCR is well known to be useful for predicting adverse health outcomes, including falls and dementia. However, around four out of five older Korean adults reported SCCs, thereby, it may not be discriminative to define MCR in Korea. We adopted the three-item recall (3IR) test, instead of SCCs, to define MCR. This cross-sectional analysis included 2133 community-dwelling older adults aged 70–84 years, without dementia or any dependence in activities of daily living from the Korean Frailty and Aging Cohort Study. The newly attempted criteria of MCR using 3IR were met by 105 participants (4.9%). MCR using 3IR showed synergistic effects on fall-related outcomes, whereas the conventional definition of MCR using SCCs was not superior to SG only. MCR using 3IR was associated with falls (odds ratio [OR]: 1.92; 95% confidence interval (CI): 1.16–3.16), recurrent falls (OR: 2.19; 95% CI: 1.12–4.32), falls with injury (OR: 1.98; 95% CI: 1.22–3.22), falls with fracture (OR: 2.51; 95% CI: 1.09–5.79), fear of falling (OR: 3.00; 95% CI: 1.83–4.92), and low activities-specific balance confidence (OR: 3.13; 95% CI: 1.57–6.25). We found that MCR using 3IR could be useful in predicting fall-related outcomes in a cultural background reporting more SCCs, such as Korea.

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Section: Discussionmentioning

confidence: 99%

Motoric Cognitive Risk Syndrome Using Three-Item Recall Test and Its Associations with Fall-Related Outcomes: The Korean Frailty and Aging Cohort Study

Shim

Kim

Won

2020

IJERPH

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“…Notably, poor gait performance, particularly under dual-tasking, has been proposed as a motor signature of aMCI [8]. It is noteworthy that the co-occurrence of cognitive complaints and slow gait, a condition referred to as motoric cognitive risk syndrome, identifies individuals at especially high risk to progress to dementia [70,71]. Along similar lines, low muscle strength of upper and lower extremities has shown to increase the risk of MCI progression into AD [72].…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, atrophy and amyloid deposition in a network encompassing the dorsolateral prefrontal cortex, cingulate gyrus, parietal association areas, basal ganglia, and medial temporal lobes (particularly the hippocampus) are thought to mediate the relationship between cognitive function and physical performance [73]. Thus, individuals who exhibit both cognitive and motor deficits may have greater underlying brain damage [71]. This implies that the simultaneous analysis of cognitive and physical function may help identify a subset of MCI persons at greater risk of conversion to dementia [71,74].…”

Section: Discussionmentioning

confidence: 99%

“…Thus, individuals who exhibit both cognitive and motor deficits may have greater underlying brain damage [71]. This implies that the simultaneous analysis of cognitive and physical function may help identify a subset of MCI persons at greater risk of conversion to dementia [71,74]. The observation that low muscle mass is commonly observed in conjunction with cognitive impairment [75,76] suggests that the inclusion of body composition analysis might further refine the identification of people more likely to progress from MCI to dementia.…”

Section: Discussionmentioning

confidence: 99%

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The “develOpment of metabolic and functional markers of Dementia IN Older people” (ODINO) Study: Rationale, Design and Methods

Picca

Ronconi

Coelho-Júnior

et al. 2020

JPM

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Mild cognitive impairment (MCI), also termed mild neurocognitive disorder, includes a heterogeneous group of conditions characterized by declines in one or more cognitive domains greater than that expected during "normal" aging but not severe enough to impair functional abilities. MCI has been associated with an increased risk of developing dementia and even considered an early stage of it. Therefore, noninvasively accessible biomarkers of MCI are highly sought after for early identification of the condition. Systemic inflammation, metabolic perturbations, and declining physical performance have been described in people with MCI. However, whether biological and functional parameters differ across MCI neuropsychological subtypes is presently debated. Likewise, the predictive value of existing biomarkers toward MCI conversion into dementia is unclear. The "develOpment of metabolic and functional markers of Dementia IN Older people" (ODINO) study was conceived as a multi-dimensional investigation in which multi-marker discovery will be coupled with innovative statistical approaches to characterize patterns of systemic inflammation, metabolic perturbations, and physical performance in older adults with MCI. The ultimate aim of ODINO is to identify potential biomarkers specific for MCI subtypes and predictive of MCI conversion into Alzheimer's disease or other forms of dementia over a three-year follow-up. Here, we describe the rationale, design, and methods of ODINO.

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“…The coexistence of immobility and mild cognitive impairment could be an early sign of dementia, and this status is currently proposed as motoric cognitive risk (MCR) [ 170 , 171 , 172 ]. Since dementia has a direct impact on quality of life and social activities for COPD patients, clarifying the association between frailty and MCR will help to develop a novel approach to avoid a sedentary life and cognitive risk.…”

Section: Systemic Comorbiditiesmentioning

confidence: 99%

Comorbid Conditions in Chronic Obstructive Pulmonary Disease: Potential Therapeutic Targets for Unmet Needs

Matsunaga

Harada

Suizu

et al. 2020

JCM

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The management of chronic obstructive pulmonary disease (COPD) has improved significantly due to advances in therapeutic agents, but it has also become apparent that there are issues that remain difficult to solve with the current treatment algorithm. COPD patients face a number of unmet needs concerning symptoms, exacerbations, and physical inactivity. There are various risk factors and triggers for these unmet needs, which can be roughly divided into two categories. One is the usual clinical characteristics for COPD patients, and the other is specific clinical characteristics in patients with comorbid conditions, such as asthma, cardiovascular disease, and bronchiectasis. These comorbidities, which are also associated with the diversity of COPD, can cause unmet needs resistance to usual care. However, treatable conditions that are not recognized as therapeutic targets may be latent in patients with COPD. We again realized that treatable traits should be assessed and treated as early as possible. In this article, we categorize potential therapeutic targets from the viewpoint of pulmonary and systemic comorbid conditions, and address recent data concerning the pathophysiological link with COPD and the impact of intervention on comorbid conditions in order to obtain evidence that could enable us to provide personalized COPD management.

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Motoric cognitive risk syndrome: Integration of two early harbingers of dementia in older adults

Cited by 60 publications

References 268 publications

Motoric Cognitive Risk Syndrome Using Three-Item Recall Test and Its Associations with Fall-Related Outcomes: The Korean Frailty and Aging Cohort Study

Motoric Cognitive Risk Syndrome Using Three-Item Recall Test and Its Associations with Fall-Related Outcomes: The Korean Frailty and Aging Cohort Study

The “develOpment of metabolic and functional markers of Dementia IN Older people” (ODINO) Study: Rationale, Design and Methods

Comorbid Conditions in Chronic Obstructive Pulmonary Disease: Potential Therapeutic Targets for Unmet Needs

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