Movement of Oxygen, Glucose, and Lactate across the Uterus of the Awake Near-Term Guinea Pig

Ll, Peeters; Mårtensson, Lars-Göran; Bk, van Kreel; Pr, Saxena; Hc, Wallenburg

doi:10.1203/00006450-198608000-00006

Cited by 5 publications

(2 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Having made this point, elegant studies by Peeters's team used indwelling catheters to show fat uptake by the uterus and the fetus (Peeters et al . , ). Molecular biology techniques are less developed than in mice and rats, requiring custom rather than ‘off the shelf’ solutions.…”

Section: Introductionmentioning

confidence: 99%

Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic

Morrison

Botting

Darby

et al. 2018

The Journal of Physiology

125

108

View full text Add to dashboard Cite

Over 30 years ago Professor David Barker first proposed the theory that events in early life could explain an individual's risk of non-communicable disease in later life: the developmental origins of health and disease (DOHaD) hypothesis. During the 1990s the validity of the DOHaD hypothesis was extensively tested in a number of human populations and the mechanisms underpinning it characterised in a range of experimental animal models. Over the past decade, researchers have sought to use this mechanistic understanding of DOHaD to develop therapeutic interventions during pregnancy and early life to improve adult health. A variety of animal models have been used to develop and evaluate interventions, each with strengths and limitations. It is becoming apparent that effective translational research requires that the animal paradigm selected mirrors the tempo of human fetal growth and development as closely as possible so that the effect of a perinatal insult and/or therapeutic intervention can be fully assessed. The guinea pig is one such animal model that over the past two decades has demonstrated itself to be a very useful platform for these important reproductive studies. This review highlights similarities in the in utero development between humans and guinea pigs, the strengths and limitations of the guinea pig as an experimental model of DOHaD and the guinea pig's potential to enhance clinical therapeutic innovation to improve human health.

show abstract

Section: Introductionmentioning

confidence: 99%

Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic

Morrison

Botting

Darby

et al. 2018

The Journal of Physiology

125

108

View full text Add to dashboard Cite

show abstract

“…Studies in the guinea pig (1 5), rabbit (1 6), and rat (1 7) have demonstrated a relation between uteroplacental blood flow and fetal growth. Uteroplacental blood flow directly influences metabolic fuel provision and gaseous exchange to the fetus (18). Inasmuch as we did not measure uteroplacental blood flow, we can only speculate if selective artery ligation increased blood flow to the remaining fetuses.…”

Section: Gestation (Days)mentioning

confidence: 99%