2005
DOI: 10.1111/j.1365-2885.2005.00674.x
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Moxidectin and ivermectin metabolic stability in sheep ruminal and abomasal contents

Abstract: The oral administration of macrocyclic lactones to sheep leads to poorer efficacy and shorter persistence of the antiparasitic activity compared to the subcutaneous treatment. Gastrointestinal biotransformation occurring after oral treatment to ruminant species has been considered as a possible cause of the differences observed between routes of administration. The current work was addressed to evaluate on a comparative basis the in vitro metabolism of moxidectin (MXD) and ivermectin (IVM) in sheep ruminal and… Show more

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Cited by 25 publications
(17 citation statements)
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“…There are many factors that potentially influence the effects of anthelmintics on seeds and varying responses can be expected for different grazing systems: seed characteristics (size, shape, hardness of seed coat, retention time in the gastrointestinal tract of an ungulate species), animal characteristics (type of digestive tract, feeding and defecation behavior), drug characteristics (formulation) and livestock management (dose, route, time point and frequency of anthelmintic administration; e.g. [41]). These factors are partly related to each other, e.g.…”
Section: Discussionmentioning
confidence: 99%
“…There are many factors that potentially influence the effects of anthelmintics on seeds and varying responses can be expected for different grazing systems: seed characteristics (size, shape, hardness of seed coat, retention time in the gastrointestinal tract of an ungulate species), animal characteristics (type of digestive tract, feeding and defecation behavior), drug characteristics (formulation) and livestock management (dose, route, time point and frequency of anthelmintic administration; e.g. [41]). These factors are partly related to each other, e.g.…”
Section: Discussionmentioning
confidence: 99%
“…Similar percentages of adsorption to the particulate phase of ruminal contents were determined for MNP and MNPSO 2 in sheep and cattle. The percentage of adsorption to the solid material observed in the current work was similar to those previously reported for the macrocyclic lactones ivermectin and moxidectin, which showed values ranging between 90.8 and 98.6%, respectively (Lifschitz et al ., ). Earlier investigations demonstrated that the rumen acts as a reservoir and prolong the duration of absorption and/or outflow down the GI tract of different benzimidazole anthelmintics (reviewed in Hennessy, ; Lanusse & Prichard, ).…”
Section: Discussionmentioning
confidence: 97%
“…The degree of adsorption to the particulate material of GI contents has been among the most studied factors effecting the gastrointestinal disposition of benzimidazole anthelmintics in sheep and cattle (Taylor et al ., ; Lanusse & Prichard, ; Hennessy et al ., ; Sánchez et al ., ). Likewise, the association of orally administered anthelmintics to the particulate phase of the GI content was early described for oxfendazole (Ali & Hennessy, ), ivermectin (Steel, ; Ali & Hennessy, ; Lifschitz et al ., ) and moxidectin (Lifschitz et al ., ). Similar percentages of adsorption to the particulate phase of ruminal contents were determined for MNP and MNPSO 2 in sheep and cattle.…”
Section: Discussionmentioning
confidence: 98%
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