MR-defined fat infiltration of the lumbar paravertebral muscles differs between non-radiographic axial spondyloarthritis and established ankylosing spondylitis

Akgül, Özgür; Gulkesen, Arif; Akgol, Gurkan; Özgöçmen, Salih

doi:10.3109/s10165-012-0750-6

Cited by 21 publications

(15 citation statements)

References 16 publications

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“…Fatty degeneration in the paravertebral muscles was divided into five grades for classification: grade 0 was defined as normal, grade I as minimal focal or linear fat deposition within the muscle, grade II as fat deposition up to 25%, grade III as fat deposition of 25%-50%, and grade IV as fat deposition of more than 50% (Figs. 1-6) [13].…”

Section: ) Modic Changesmentioning

confidence: 99%

The Prevalence of Lumbar Paraspinal Muscle Fatty Degeneration in Patients with Modic Type I and I/II End Plate Changes

Atçı¹,

Yılmaz

Samancı

et al. 2020

Asian Spine J

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Study Design: Retrospective case control.Purpose: The authors of this study assessed whether the prevalence of paraspinal fatty degeneration correlates with the presence of Modic type I and I/II change in patients with low back pain (LBP).Overview of Literature: Modic changes are bone marrow and end plate changes visible on magnetic resonance imaging.Methods: A consecutive series of 141 patients who attended the neurosurgery outpatient clinic between April 2017 and September 2017 for nonspecific LBP were evaluated. Sixty-one patients with single-level Modic type I or I/II change constituted the patient group. Eighty age-, gender-, and body mass index (BMI)-matched patients without any Modic changes were recruited as the control group. A retrospective review was performed in 61 patients with Modic changes and 80 controls without Modic changes. The percentage of fatty muscle degeneration was graded by two reviewers using T2-weighted axial images at the L4–L5 level. The system was graded as follows: grade 0, normal; grade I, minimal focal or linear fat deposition; grade II, up to 25%; grade III, 25%–50%; and grade IV, more than 50%.Results: Sixty-one patients with nonspecific LBP and Modic type I or I/II change and 80 patients without Modic changes were evaluated. There was no difference between these groups in terms of age, gender, and BMI distribution. The mean muscle cross-sectional area in the patient and control groups were 1,507.37±410.63 and 1,681.64±379.69. Regarding fatty degeneration, a chi-square test of homogeneity was run, and the two multinomial probability distributions were not equal within the population analyzed.Conclusions: The novel finding of this investigation is that patients with Modic type I and I/II changes have greater amounts of fatty degeneration in their lumbar paraspinal musculature.

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Section: ) Modic Changesmentioning

confidence: 99%

The Prevalence of Lumbar Paraspinal Muscle Fatty Degeneration in Patients with Modic Type I and I/II End Plate Changes

Atçı¹,

Yılmaz

Samancı

et al. 2020

Asian Spine J

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“…However, patients with AS showed higher grades of fat infiltration than those with nr-axSpA, with this difference remaining significant after the two groups were matched for age and symptom duration. These results suggest that the paravertebral muscles in patients with SpA at different disease stages may not necessarily change in size, although their structure may differentiate toward fatty degeneration when the disease is established (45). This is an important aspect that complements the information obtained with DXA and CT.…”

Section: Muscle Evaluation In Spamentioning

confidence: 98%

“…To analyze the influence of disease duration and severity, a comparison study has been conducted in AS and in non-radiographic Axial Spondyloarthritis (nr-axSpA) patients. The cross-sectional areas (CSA) of the lumbar paravertebral muscles, including the right and left multifidus (MF), the erector spina (ES), and the psoas (PS), at multiple levels were similar between the two groups (45). However, patients with AS showed higher grades of fat infiltration than those with nr-axSpA, with this difference remaining significant after the two groups were matched for age and symptom duration.…”

Section: Muscle Evaluation In Spamentioning

confidence: 99%

“…This is an important aspect that complements the information obtained with DXA and CT. This comparison study opens the possibility that the restricted spinal movement induced by the disease is one of the main factors leading to the disuse and consequent atrophy of paravertebral muscles, with considerable impact on the patients' quality of life (45).…”

Section: Muscle Evaluation In Spamentioning

confidence: 99%

“…In fact, CBP patients with the same or a higher degree of immobility and functional impairment as AS patients show the same pattern of fiber atrophy and fat infiltration but striking differences as regards fibrosis. This suggests that paraspinal muscle fibrosis in AS represents a specific pathological process that may be related with inflammation (44) in addition to pain or reduced spinal mobility (45). However, several studies have consistently shown that histological paraspinal muscle abnormalities in AS occur without obvious inflammatory cell infiltrates (26, 44).…”

Section: Muscle Evaluation In Spamentioning

confidence: 99%

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Muscle Evaluation in Axial Spondyloarthritis—The Evidence for Sarcopenia

2019

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Sarcopenia is a syndrome defined as a progressive and generalized skeletal muscle disorder associated with an increased likelihood of adverse outcomes such as falls, fractures, physical disability, and death. The actual definition of sarcopenia is based on a reduction in the values of three parameters: strength, muscle mass quantity or quality, and physical performance (the determinant of severity). Muscle wasting is a common feature in several chronic diseases, such as spondyloarthritis (SpA), and significantly increases patient morbidity and mortality. Although there has been huge progress in this field over recent years, the absence of a clear definition and clear diagnostic criteria of sarcopenia has resulted in inconsistent information regarding muscle-involvement in SpA. Thus, the aim of this review is to collect relevant evidence on muscular changes occurring during the disease process from the published literature, according to the recommended tools for sarcopenia evaluation proposed by the European Working Group on Sarcopenia in Older People 2 (EWGSOP2). In addition, data from histological, electromyography, and biochemical muscle analyses of SpA patients are also reviewed. Overall, a reduction in muscle strength with a systemic decrease in lean mass seems to be associated with a gait speed compromise. This information is usually fragmented, with no studies considering the three parameters together. This paper represents a call-to-action for the design of new studies in the future.

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Quantification of fat deposition in the testis and epididymis using mDIXON Quant sequence: correlation with age and ejaculation

et al. 2018

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MR-defined fat infiltration of the lumbar paravertebral muscles differs between non-radiographic axial spondyloarthritis and established ankylosing spondylitis

Cited by 21 publications

References 16 publications

The Prevalence of Lumbar Paraspinal Muscle Fatty Degeneration in Patients with Modic Type I and I/II End Plate Changes

The Prevalence of Lumbar Paraspinal Muscle Fatty Degeneration in Patients with Modic Type I and I/II End Plate Changes

Muscle Evaluation in Axial Spondyloarthritis—The Evidence for Sarcopenia

Quantification of fat deposition in the testis and epididymis using mDIXON Quant sequence: correlation with age and ejaculation

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