MR imaging of autologous chondrocyte implantation of the knee

James, Stanley L.; Connell, David; Saifuddin, Asif; Skinner, John; Briggs, Timothy

doi:10.1007/s00330-005-0051-y

Cited by 19 publications

(4 citation statements)

References 48 publications

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“…With the FSE sequence, the repair tissue initially appears brighter and a decrease in signal intensity is to be expected with time. 42,91 At 12 months, the signal behavior of repair tissue more closely resembles native cartilage 58,70,86,87 in the majority of cases with both sequences (Fig. 8).…”

Section: Signal Intensitymentioning

confidence: 83%

MRI Monitoring of Cartilage Repair in the Knee: A Review

Domayer

Welsch

Dorotka

et al. 2008

Semin Musculoskelet Radiol

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Various treatment options for deep cartilage defects are presently available. The efficacy of bone marrow stimulation with microfracture, of mosaicplasty and of various autologous chondrocyte implantation (ACI) techniques has been subject to numerous studies recently. Magnetic resonance imaging (MRI) has gained a major role in the assessment of cartilage repair. The introduction of high-field MRI to clinical routine makes high resolution and three-dimensional imaging readily available. New quantitative MRI techniques that directly visualize the molecular structure of cartilage may further advance our understanding of cartilage repair. The clinical evaluation of cartilage repair tissue is a complex issue, and MR imaging will become increasingly important both in research and in clinical routine. This article reviews the clinical aspects of microfracture, mosaicplasty, and ACI and reports the recent technical advances that have improved MRI of cartilage. Morphological evaluation methods are recommended for each of the respective techniques. Finally, an overview of T2 mapping and delayed gadolinium-enhanced MR imaging of cartilage in cartilage repair is provided.

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Section: Signal Intensitymentioning

confidence: 83%

MRI Monitoring of Cartilage Repair in the Knee: A Review

Domayer

Welsch

Dorotka

et al. 2008

Semin Musculoskelet Radiol

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“…Chondrocyte implantation has been performed with autologous chondrocytes and allografts. The cartilage defect is debrided and filled with a suspension of cultured chondrocytes and covererd by a periosteal flap or chondrocyte-impregnated scaffolds [8]. The results are somewhat controversial [9,10], with one study indicating that cartilage repair tissue was of varying morphology ranging from predominantly hyaline in 22% of biopsy specimens, to mixed in 48%, and to predominantly fibrocartilage in 30% [10].…”

Section: What Therapies Are Available?mentioning

confidence: 99%

Cartilage imaging: motivation, techniques, current and future significance

2006

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Cartilage repair techniques and pharmacological therapies are currently areas of major clinical interest and research, in particular to prevent and treat osteoarthritis. MR imaging-based techniques to visualize cartilage are prerequisites to guide and monitor these therapies. In this review article, standard MR imaging sequences are described, including proton density-weighted fast spin echo, spoiled gradient echo and dual echo steady state sequences. In addition, new sequences that have been developed and are currently being investigated are presented, including driven equilibrium Fourier transform and steady-state free precession-based imaging. Using high-field MR imaging at 3.0-T, visualization of cartilage and the related pathology has been improved. Volumetric quantitative cartilage MR imaging was developed as a tool to monitor the progression of osteoarthritis and to evaluate new pharmacological cartilage protective therapies. The most exciting developments, however, are in the field of cartilage matrix assessment with quantitative dGEMRIC, T2 and T1rho mapping techniques. These techniques aim at detecting cartilage damage at a stage when changes are potentially still reversible, before cartilage tissue is lost. There is currently substantial interest in these techniques from rheumatologists and orthopedists; radiologists therefore need to keep up with these developments.

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“…Although no second‐look arthroscopy or histological examination was performed to assess the quality of the repair tissue in this study, the evaluation of the repair tissue via the MOCART score showed excellent results and a further improvement when compared to the short‐term results. Several studies have investigated the reliability of the MOCART score itself and shown excellent interobserver reliability and a good correlation with clinical results especially for the criteria ‘filling of the defect’, ‘structure of the repair tissue’, ‘changes in the subchondral bone’, and ‘signal intensities of the repair issue’, thus making high‐resolution MRI a reliable, reproducible, and accurate tool for assessing cartilage repair tissue non‐invasively [13, 18].…”

Section: Discussionmentioning

confidence: 99%