MR-Thermometrie bei 1,5 Tesla zur thermischen Ablation mittels laserinduzierter Thermotherapie

Meister, D.; Hübner, Frank; Mack, MG; Vogl, Thomas

doi:10.1055/s-2007-962979

Cited by 19 publications

(2 citation statements)

References 15 publications

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“…MRI-guided LITT is showing increasing promise as a technique for the treatment of a variety of primary and secondary malignant tumors [39–42]. Yet, despite its efficacy in well-selected patients, image-guided LITT is still far less frequently used than RF ablation techniques due to an inability to generate sufficiently high, tumor-specific heating [43].…”

Section: Discussionmentioning

confidence: 99%

Development of Iron-Containing Multiwalled Carbon Nanotubes for MR-Guided Laser-Induced Thermotherapy

et al. 2011

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Aims To test iron-containing multiwalled carbon nanotubes (MWCNTs) as bifunctional nanomaterials for imaging and thermal ablation of tumors. Materials & Methods MWCNTs entrapping iron were synthesized by chemical vapor deposition. The T2-weighted contrast enhancement properties of MWCNTs containing increasing amounts of iron were determined in vitro. Suspensions of these particles were injected into tumor-bearing mice and tracked longitudinally over 7 days by MRI. Heat-generating abilities of these nanomaterials following exposure to near infrared (NIR) laser irradiation was determined in vitro and in vivo. Results The magnetic resonance contrast properties of carbon nanotubes were directly related to their iron content. Iron-containing nanotubes were functional T2-weighted contrast agents in vitro and could be imaged in vivo long-term following injection. Iron content of nanotubes did not affect their ability to generate thermoablative temperatures following exposure to NIR and significant tumor regression was observed in mice treated with MWCNTs and NIR laser irradiation. Conclusion These data demonstrate that iron-containing MWCNTs are functional T2-weighted contrast agents and efficient mediators of tumor-specific thermal ablation in vivo.

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Section: Discussionmentioning

confidence: 99%

Development of Iron-Containing Multiwalled Carbon Nanotubes for MR-Guided Laser-Induced Thermotherapy

et al. 2011

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“…The temperature of the transponder was stable during the 1.5 T MRI RF heating, and its variation was <0.2 • C, within the detectability of the thermometer. The temperature change cannot be monitored by non-invasive MRI thermometry (Meister et al 2007) as a result of substantial image artifacts caused by the implanted transponder.…”

Section: Interference Of Calypso Transponders With Mri and Ctmentioning

confidence: 99%

Tradeoffs of integrating real-time tracking into IGRT for prostate cancer treatment

et al. 2009

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This study investigated the integration of the Calypso real-time tracking system, based on implanted ferromagnetic transponders and a detector array, into the current process for image-guided radiation treatment (IGRT) of prostate cancer at our institution. The current IGRT process includes magnetic resonance imaging (MRI) for prostate delineation, CT simulation for treatment planning, daily on-board kV and CBCT imaging for target alignment, and MRI/MRS for post-treatment assessment. This study assesses (1) magnetic-field-induced displacement and radio-frequency (RF)-induced heating of transponders during MRI at 1.5 T and 3 T, and (2) image artifacts caused by transponders and the detector array in phantom and patient cases with the different imaging systems. A tissue-equivalent phantom mimicking prostate tissue stiffness was constructed and implanted with three operational transponders prior to phantom solidification. The measurements show that the Calypso system is safe with all the imaging systems. Transponder position displacements due to the MR field are minimal (<1.0 mm) for both 1.5 T and 3 T MRI scanners, and the temperature variation due to MRI RF heating is <0.2 degrees C. The visibility of transponders and bony anatomy was not affected on the OBI kV and CT images. Image quality degradation caused by the detector antenna array is observed in the CBCT image. Image artifacts are most significant with the gradient echo sequence in the MR images, producing null signals surrounding the transponders with radii approximately 1.5 cm and length approximately 4 cm. Thus, Calypso transponders can preclude the use of MRI/MRS in post-treatment assessment. Modifications of the clinical flow are required to accommodate and minimize the substantial MRI artifacts induced by the Calypso transponders.

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Radiofrequency Heating Models and Measurements

Shrivastava

Vaughan

2011

Encyclopedia of Magnetic Resonance

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MR-Thermometrie bei 1,5 Tesla zur thermischen Ablation mittels laserinduzierter Thermotherapie

Cited by 19 publications

References 15 publications

Development of Iron-Containing Multiwalled Carbon Nanotubes for MR-Guided Laser-Induced Thermotherapy

Development of Iron-Containing Multiwalled Carbon Nanotubes for MR-Guided Laser-Induced Thermotherapy

Tradeoffs of integrating real-time tracking into IGRT for prostate cancer treatment

Radiofrequency Heating Models and Measurements

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