MRI contrast enhancement potential of different superparamagnetic iron oxide nanoparticle (SPION) formulations

Schweiger, Christoph; Gil, Pilar Rivera; Parak, Wolfgang J.; Kissel, Thomas

doi:10.1016/j.jconrel.2010.07.029

Cited by 6 publications

(3 citation statements)

References 5 publications

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“…The physical and chemical differences of SPIONs produced by different design and synthesis schemes [70][71][72] offer the possibilities of cell-specific patterning to assemble spatially heterogeneous multicellular tissue structures. Different magnetic templates can be adapted and created using CAD, which can then be used to spatially pattern heterogeneous spheroid populations as well as individual multicellular aggregates for the construction of hybrid 3D multicellular tissues.…”

Section: Discussionmentioning

confidence: 99%

Magnetic‐directed patterning of cell spheroids

Whatley

Zhang

et al. 2013

J Biomedical Materials Res

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We have described an approach to fabricate three-dimensional (3D) cell-based structures using functionalized super paramagnetic iron oxide nanoparticles (SPIONs) as patterning agents to guide the assembly of endothelial cell spheroids into 3D patterns using the magnetic forces generated by a prefabricated magnetic template. SPIONs were first uptaken by endothelial cells before they were assembled into uniform-sized spheroids through a home-made robotic spheroid maker. To guide the magnetic spheroids, a unique magnetic template was fabricated using computer-aided design and cut from a magnetic sheet. The spheroids were then guided to the prefabricated magnetic template through the attractive magnetic forces between the SPIONs inside the endothelial cells and the magnetic template. Fusion of endothelial cell spheroids over time while adhered to the magnetic template allowed for the formation of 3D cell-based structures. Subsequent removal of the prefabricated magnetic template left 3-D endothelial cell sheets, which may be stacked to fabricate complicated 3D multicellular tissue structures. To enhance the cytocompatibility, SPIONs were silica-coated before use. At low concentrations, the SPIONs did not adversely affect cell viability, proliferation, and phenotype stability. Light and confocal microscopy showed that endothelial cell spheroids could be reproducibly created with high uniformity. The endothelial cells were able to remain viable and maintain the 3D structure in vitro. We have proved the concept to use SPIONs as a patterning agent to direct the attachment and self assembly of SPION-loaded endothelial cell spheroids on a prefabricated magnetic template for the formation of 3D cell based structures. A magnetic-directed technique allows quick patterning of cell spheroids in accordance with desirable magnetic patterns, therefore, holding promise for scalable fabrication of complicated 3D multicellular tissue structures. By varying the cell types and the prefabricated magnetic patterns, this magnetic-directed patterning strategy may find use in bioprinting and multicellular tissue graft fabrication.

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Section: Discussionmentioning

confidence: 99%

Magnetic‐directed patterning of cell spheroids

Whatley

Zhang

et al. 2013

J Biomedical Materials Res

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“…56 Altogether, SPIONs are potential candidates for improving contrast enhancement in magnetic resonance imaging (MRI), hyperthermia 57 , molecular detection and drug delivery. 58 Iron oxide NPs are being used in clinical trials as contrast agents in magnetic resonance imaging (MRI), 59 a powerful tool for non-invasive and non-destructive diagnostic applications in various clinical and biomedical settings. Briefly, imaging contrast of MR is based on the different relaxation times of water protons in tissue.…”

Section: Magnetic Nanoparticlesmentioning

confidence: 99%

Targeted uptake of folic acid-functionalized iron oxide nanoparticles by ovarian cancer cells in the presence but not in the absence of serum

Krais

Wortmann

Hermanns

et al. 2014

Nanomedicine: Nanotechnology, Biology and Medicine

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“…Magnetic nanoparticles have ultra-high magnetic mobility, good biological compatibility, and the easy modification of targeted carriers has led to their decoration with effective contrast agents (Lu et al, 2007;Etoc et al, 2015;Storey et al, 2020). Superparamagnetic iron oxide nanoparticles (SPION) (Bulte and Kraitchman, 2004;Stoll and Bendszus, 2009;Schweiger et al, 2010), commonly used as magnetic nanoparticles for biomedical applications, are another MRI-compatible nanomaterial that provide sufficient sensitivity for MRI t2-weighted imaging (Ling and Hyeon, 2013;Zeng et al, 2017). Accordingly, SPION particles have found clinical usage (Bergamino et al, 2014).…”

Section: Super Paramagnetic Iron Oxide: a Nanoprobe For Super Magneti...mentioning

confidence: 99%

Advances in nanotechnology for the treatment of GBM

et al. 2023

Front. Neurosci.

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Glioblastoma (GBM), a highly malignant glioma of the central nervous system, is the most dread and common brain tumor with a high rate of therapeutic resistance and recurrence. Currently, the clinical treatment methods are surgery, radiotherapy, and chemotherapy. However, owning to the highly invasive nature of GBM, it is difficult to completely resect them due to the unclear boundary between the edges of GBM and normal brain tissue. Traditional radiotherapy and the combination of alkylating agents and radiotherapy have significant side effects, therapeutic drugs are difficult to penetrate the blood brain barrier. Patients receiving treatment have a high postoperative recurrence rate and a median survival of less than 2 years, Less than 5% of patients live longer than 5 years. Therefore, it is urgent to achieve precise treatment through the blood brain barrier and reduce toxic and side effects. Nanotechnology exhibit great potential in this area. This article summarizes the current treatment methods and shortcomings of GBM, and summarizes the research progress in the diagnosis and treatment of GBM using nanotechnology.

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MRI contrast enhancement potential of different superparamagnetic iron oxide nanoparticle (SPION) formulations

Cited by 6 publications

References 5 publications

Magnetic‐directed patterning of cell spheroids

Magnetic‐directed patterning of cell spheroids

Targeted uptake of folic acid-functionalized iron oxide nanoparticles by ovarian cancer cells in the presence but not in the absence of serum

Advances in nanotechnology for the treatment of GBM

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