MRI of Temporal Lobe Pleomorphic Xanthoastrocytoma

Rippe, David J.; Boyko, Orest B.; Radi, Michael J.; Worth, Robert M.; Fuller, Gregory N.

doi:10.1097/00004728-199211000-00004

Cited by 45 publications

(20 citation statements)

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“…The solid portion of the tumor is isointense to gray matter on T1-weighted images and hyperintense on T2-weighted images (Tonn et al 1997). Most commonly, minimal edema is observed on MRI (Rippe et al 1992). Increased signal intensity on proton-density and T2-weighted images in both the cystic and solid components of the tumors has also been described (Yoshino & Lucio 1992).…”

Section: Diagnosismentioning

confidence: 97%

Uncommon glial tumors

Chen¹,

Elder²,

González-Gómez³

et al. 2012

Brain Tumors

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Section: Diagnosismentioning

confidence: 97%

Uncommon glial tumors

Chen¹,

Elder²,

González-Gómez³

et al. 2012

Brain Tumors

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“…homeostasis and abnormal electrophysiological characteristics [182][183][184][185][186]. Calcification, sometimes combined with cyst formation [187], is a common pathological feature of these tumors [188][189][190].…”

Section: Car and Neoplasm Of Central Nervous Systemmentioning

confidence: 99%

Calcium-sensing receptor in cancer: good cop or bad cop?

Chakravarti

Dwivedi

Mithal

et al. 2008

Endocr

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The extracellular calcium-sensing receptor (CaR) is a versatile 'sensor' for di- and polycationic molecules in the body. CaR plays a key role in the defense against hypercalcemia by "sensing" extracellular calcium levels in the parathyroid and kidney, the key organs maintaining systemic calcium homeostasis. Although mutation of CaR gene has so far not been associated with any malignancy, aberrant functions of CaR have implications in malignant progression. One situation is loss of CaR expression, resulting in loss of growth suppressing effects of elevated extracellular Ca(2+) by CaR, reported in parathyroid adenoma and in colon carcinoma. Another situation is activation of CaR, resulting in increased production of parathyroid hormone-related peptide (PTHrP), a primary causal factor in hypercalcemia of malignancy and a contributor to metastatic processes involving bone. CaR signaling and effects have been studied in several cancers including ovarian cancers, gastrinomas, and gliomas in addition to comparatively detailed studies in breast, prostate, and colon cancers. Studies on H-500 rat Leydig cells, a xenotransplantable model of humoral hypercalcemia of malignancy has shed much light on the mechanisms of CaR-induced cancer cell growth and survival. Pharmacological agonists and antagonists of CaR hold therapeutic promise depending on whether activation of CaR is required such as in case of colon cancer or inactivating the receptor is required as in the case of breast- and prostate tumors.

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“…It is characteristically seen in young adults who present with intractable seizures, and rendered seizure free post GTR (gross total resection or within 1 year of surgery. [34] Pleomorphic xanthoastrocytomas typically appear as hypointense cystic masses with an enhancing mural nodule on T1-weighted MRI, hyperintense or mixed signal intensity on T2 weighted MRI with suppression of cyst content on FLAIR images. [5] Additionally, Raz et al .…”

Section: Discussionmentioning

confidence: 99%