2009
DOI: 10.1016/j.cub.2009.02.054
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MST2- and Furry-Mediated Activation of NDR1 Kinase Is Critical for Precise Alignment of Mitotic Chromosomes

Abstract: The precise alignment of chromosomes on the metaphase plate prior to the onset of anaphase is essential for ensuring equal segregation of sister chromatids into two daughter cells, and defects in this process potentially cause chromosome instability and tumor progression [1-3]. NDR1 is an evolutionarily conserved serine/threonine kinase whose activity is regulated by MST kinases, Furry (Fry), and MOB [4]. Although the NDR1 signaling pathway is implicated in cell division and morphogenesis in yeast and inverteb… Show more

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Cited by 102 publications
(165 citation statements)
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“…In line with this finding, a second publication reported that MST2 signalling plays a role in chromosome alignment in metaphase [74]. Whether MST2 can also influence Aurora B activity is currently not known, but MST1 and MST2 both appear to signal through NDR1 kinase (the human counterpart of Trc in flies) [74,75]. Furthermore, they reported that NDR1 kinase activity is elevated in early mitosis [74].…”
Section: Mammalian Hippo Signalling In the G2/m Phase Of The Cell Cyclementioning
confidence: 73%
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“…In line with this finding, a second publication reported that MST2 signalling plays a role in chromosome alignment in metaphase [74]. Whether MST2 can also influence Aurora B activity is currently not known, but MST1 and MST2 both appear to signal through NDR1 kinase (the human counterpart of Trc in flies) [74,75]. Furthermore, they reported that NDR1 kinase activity is elevated in early mitosis [74].…”
Section: Mammalian Hippo Signalling In the G2/m Phase Of The Cell Cyclementioning
confidence: 73%
“…Oh et al (2010) provided evidence suggesting that Aurora B kinase activity is regulated by MST1 signalling, thereby linking MST1 to the molecular processes of chromosome segregation in mitosis [75]. In line with this finding, a second publication reported that MST2 signalling plays a role in chromosome alignment in metaphase [74]. Whether MST2 can also influence Aurora B activity is currently not known, but MST1 and MST2 both appear to signal through NDR1 kinase (the human counterpart of Trc in flies) [74,75].…”
Section: Mammalian Hippo Signalling In the G2/m Phase Of The Cell Cyclementioning
confidence: 86%
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