Mucin-like carcinoma-associated antigen (MCA) during normal pregnancy

Sarandakou, Angeliki; Rizos, Demetrios; Botsis, D.; Kassanos, D; Thomopoulos, P.; Protonotariou, Efthimia; Phocas, I.

doi:10.1016/s0301-2115(00)00384-5

Cited by 5 publications

(3 citation statements)

References 12 publications

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“…Some of these antibodies, as well as lectins, are useful for the characterisation of alterations in mucin expression or glycosylation, which accompany the development of cancer and influence cellular growth, differentiation, transformation, adhesion, invasion and immune surveillance. [25,[40][41][42][43][44]50,54,133,[136][137][138][139][140][141][142][143][144][145] From a medical point of view, these studies are particularly important for potential diagnostics or therapeutic consequences. [54,133,142,146] This section will serve to review the biochemical and biophysical alterations of MUC2 as a predominant colonic mucin, occurring during the malignant transformation of benign adenoma to colorectal carcinoma by using an in vitro adenoma-carcinoma sequence.…”

Section: Mucins and Tumoursmentioning

confidence: 99%

“…A large number of monoclonal antibodies directed against the protein core and diverse carbohydrate epitopes of mucins have been produced. Some of these antibodies, as well as lectins, are useful for the characterisation of alterations in mucin expression or glycosylation, which accompany the development of cancer and influence cellular growth, differentiation, transformation, adhesion, invasion and immune surveillance 25,40–44,50,54,133,136–145. From a medical point of view, these studies are particularly important for potential diagnostics or therapeutic consequences 54,133,142,146…”

Section: Mucins and Tumoursmentioning

confidence: 99%

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Mucin Macromolecules in Normal, Adenomatous, and Carcinomatous Colon: Evidence for the Neotransformation

Aksoy

Akinci

2004

Macromolecular Bioscience

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Mucins are high molecular-weight glycoproteins having oligosaccharides attached to serine or threonine residues of the mucin core protein backbone by O-glycosidic linkages. They are major components of mucus, covering the luminal surfaces of epithelial respiratory, gastrointestinal and reproductive tracts, and responsible for its viscoelastic properties. The core proteins of mucins are encoded by different mucin genes. Aberrations in the cell surface carbohydrates including mucins have been regarded as a universal characteristic of the malignant transformation of cells. These alterations are considered to be relevant to the abnormal behaviour of cancer cells, such as altered cell adhesion or metastasis, and to the avoidance of immunological defence.

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Section: Mucins and Tumoursmentioning

confidence: 99%

Section: Mucins and Tumoursmentioning

confidence: 99%

Mucin Macromolecules in Normal, Adenomatous, and Carcinomatous Colon: Evidence for the Neotransformation

Aksoy

Akinci

2004

Macromolecular Bioscience

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“…MS MCA values increased significantly with gestational age, being higher in the 3 rd trimester and in labor than in control values [33]. AF/MS ratio = ~100.…”

Section: Mucin-like Carcinoma-associated Antigen (Mca)mentioning

confidence: 77%

Search for Amniotic Fluid-Specific Markers: Novel Biomarker Candidates for Amniotic Fluid Embolism

Kobayashi

Naruse²,

Sado³

et al. 2011

TOWHJ

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Objective: Amniotic fluid embolism (AFE) is a catastrophic syndrome. The amniotic fluid (AF)-specific antigens might be assessed in maternal serum when these proteins abruptly enter maternal circulation. The aims of this study were 1) to review a conventional marker for diagnosis of AFE, and 2) to find AF-specific proteins. Study design: This article reviews the English language literature for identification of proteins specifically or exclusively present in AF. The genome-wide gene expression profiling studies and proteomics-based approaches have been reported to identify the AF-specific proteins. Results: Maternal serum sialosyl Tn (STN), zinc-coproporphyrin-1 (ZnCP-1), tryptase and complement activation are clinically used as biomarkers for detecting AFE. However, these tests are quite limited. With advances in proteomics technology, together with the considerable efforts to find novel diagnostic biomarkers, many candidate proteins have been discovered and reported. Among 44 candidate markers identified in the present review, interleukin(IL)-6, squamous cell carcinoma (SCC), insulin-like growth factor-binding protein (IGFBP)-1, CA125 and osteopontin may be unique AFspecific markers. Conclusion: This paper reviews recent advances in proteomics-based technology providing a significant resource for AFE research and a framework for biomarker discovery. Further research is needed to evaluate the potential functional biomarkers for the diagnosis of AFE.

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Cross-reactivity between MUC1 antigen and MCA: false elevation of serum CA 15-3 level in pregnant and lactating women by Ma695–Ma552-based assay

Liang

Fang

Lin

et al. 2018

Breast Cancer Res Treat

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Mucin-like carcinoma-associated antigen (MCA) during normal pregnancy

Cited by 5 publications

References 12 publications

Mucin Macromolecules in Normal, Adenomatous, and Carcinomatous Colon: Evidence for the Neotransformation

Mucin Macromolecules in Normal, Adenomatous, and Carcinomatous Colon: Evidence for the Neotransformation

Search for Amniotic Fluid-Specific Markers: Novel Biomarker Candidates for Amniotic Fluid Embolism

Cross-reactivity between MUC1 antigen and MCA: false elevation of serum CA 15-3 level in pregnant and lactating women by Ma695–Ma552-based assay

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