Mucinous adenocarcinoma of probable minor salivary gland origin

Notani, Ken‐ichi; Iizuka, Tadashi; Yamazaki, Yutaka; Henmi, Tohru; Sugiura, Chihiro; Kohgo, Takao; Fukuda, Hiroshi

doi:10.1067/moe.2002.126698

Cited by 29 publications

(18 citation statements)

References 5 publications

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“…Also positive staining for PAS, Alcian blue and mucicarmine was obtained in mucin stroma of the cancer. These findings correspond with the results presented by other authors [4,5,7,8].…”

Section: Rt -Radiotherapy Np -Neck Dissectionsupporting

confidence: 82%

“…Clinical symptoms of the head and neck MAC are uncharacteristic and diagnosis is based on the histopathological and immunohistochemical examination. In the available literature (PubMed 1973-2012) we have found 21 published cases of MAC arising from minor salivary glands localised in the palate (9 cases), buccal mucosa (4 cases), floor of the mouth (3 cases), lips (3 cases) and tongue (2 cases) [3,6,7,9]. …”

Section: Discussionmentioning

confidence: 99%

“…In addition, at least half of the tumour cells should produce mucus [8]. Histologically, MAC may be confusingly similar to the mucinous eccrine carcinoma of the skin, mucinous carcinoma of the breast and colloid carcinoma of the bowel [7]. An important feature of MAC are mucus-producing cells which show positive staining for mucicarmine and Alcian blue.…”

Section: Introductionmentioning

confidence: 99%

“…The cancer cells have clear cytoplasm and small, round, darkly-stained nuclei. The tumour cells form nests embedded in the extracellular mucin pools [3][4][5][6][7]. According to some authors the histological features are so characteristic that differential diagnosis from other malignant salivary gland tumours is straightforward [5].…”

Section: Introductionmentioning

confidence: 99%

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Minor salivary gland mucinous adenocarcinoma of buccal mucosa – and review of the literature

Wyszyńska-Pawelec¹,

Koryczan²,

Zapała³

et al. 2013

pjp

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Mucinous adenocarcinoma (MAC) is commonly found in the gastrointestinal tract but head and neck localisations are very rare. This article presents the case of a 67-yearold patient suffering from a minor salivary gland MAC of the left buccal mucosa, who was treated in the Department of Cranio-Maxillofacial Surgery in Krakow due to multiple recurrences of the tumour. The results of immunohistochemical staining, the course of surgical treatment and follow-up, as well as a review of literature are also discussed.

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“…Also positive staining for PAS, Alcian blue and mucicarmine was obtained in mucin stroma of the cancer. These findings correspond with the results presented by other authors [4,5,7,8].…”

Section: Rt -Radiotherapy Np -Neck Dissectionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Minor salivary gland mucinous adenocarcinoma of buccal mucosa – and review of the literature

Wyszyńska-Pawelec¹,

Koryczan²,

Zapała³

et al. 2013

pjp

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“…Although most cystadenocarcinomas are low grade malignancies composed of small cuboidal cells with scanty cytoplasm displaying regular nuclei with inconspicuous nucleoli, and low mitotic activity [17,20,21], others exhibit large cuboidal or columnar cells with moderate to high nuclear atypia, prominent nucleoli, and frequent mitoses [17,18,22], and lastly, some are best classified as mucinous cystadenocarcinoma [22][23][24].…”

Section: Cystadenocarcinomamentioning

confidence: 99%

Low-Grade Salivary Duct Carcinoma or Low-Grade Intraductal Carcinoma? Review of the Literature

Kuo¹,

Weinreb²,

Perez-Ordonez³

2013

Head and Neck Pathol

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Low-grade salivary duct carcinoma (LG-SDC) is a rare neoplasm characterized by predominant intraductal growth, luminal ductal phenotype, bland microscopic features, and favorable clinical behavior with an appearance reminiscent of florid to atypical ductal hyperplasia to low grade intraductal breast carcinoma. LG-SDC is composed of multiple cysts, cribriform architecture with ''Roman Bridges'', ''pseudocribriform'' proliferations with floppy fenestrations or irregular slits, micropapillae with epithelial tufts, fibrovascular cores, and solid areas. Most of the tumor cells are small to medium sized with pale eosinophilic cytoplasm, and round to oval nuclei, which may contain finely dispersed or dark condensed chromatin. Foci of intermediate to high grade atypia, and invasive carcinoma or micro-invasion have been reported in up to 23 % of cases. The neoplastic cells have a ductal phenotype with coexpression of keratins and S100 protein and are surrounded by a layer of myoepithelial cells in noninvasive cases. The main differential diagnosis of LG-SDC includes cystadenoma, cystadenocarcinoma, sclerosing polycystic adenosis, salivary duct carcinoma in situ/highgrade intraductal carcinoma, and papillary-cystic variant of acinic cell carcinoma. There is no published data supporting the continuous classification of LG-SDC as a variant of cystadenocarcinoma. Given that most LG-SDC are noninvasive neoplasms; the terms ''cribriform cystadenocarcinoma'' and LG-SDC should be replaced by ''low-grade intraductal carcinoma'' (LG-IDC) of salivary gland or ''lowgrade intraductal carcinoma with areas of invasive carcinoma'' in those cases with evidence of invasive carcinoma.

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Other Carcinomas

Hellquist

Skálová

2014

Histopathology of the Salivary Glands

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Mucinous adenocarcinoma of probable minor salivary gland origin

Cited by 29 publications

References 5 publications

Minor salivary gland mucinous adenocarcinoma of buccal mucosa – and review of the literature

Minor salivary gland mucinous adenocarcinoma of buccal mucosa – and review of the literature

Low-Grade Salivary Duct Carcinoma or Low-Grade Intraductal Carcinoma? Review of the Literature

Other Carcinomas

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