Mucoadhesive chitosan–methylcellulose oral patches for the treatment of local mouth bacterial infections

Abstract

Electrophoretic deposition allows obtaining gentamicin-loaded chitosan–methylcellulose patches (CS–MC/GS) with distinctive mucoadhesive and antibacterial characteristics, useful to treat mouth bacterial infections.

Emerging polymeric materials for treatment of oral diseases: design strategy towards a unique oral environment

“…To that end, a CS-methylcellulose patch was prepared by electrophoretic deposition, with mucoadhesive and antibacterial activities. 208 Gentamicin was loaded in the patch and released within 30 min to achieve antimicrobial activity with MICs of 2 and 16 μg mL −1 against Gram-negative E. coli and Gram-positive S. aureus . Tamayol et al designed a type of antimicrobial PCL composite patch containing zinc oxide (ZnO) as the antimicrobial agent.…”

Crosslinking strategies in modulating methylcellulose hydrogel properties

“…MC belongs to the 'generally recognized as safe (GRAS)' products by the U.S. Food and Drug Administration and is widely used in the food industry, e.g., as a thickener, an emulsifier, a stabilizer, and a fat replacer. 1,75 The latter is the field of increasing interest: strategies to impart solid-fat functionality to liquid oils 76 through cellulose derivatives appear promising in developing fat components of meat substitutes with reversible thermal behavior and texturing deriving from crosslinking. Crosslinking of MC is also generally employed for food packaging to obtain water-resistant materials with superior mechanical properties.…”

Single-step, electrophoretically deposited hydroxyapatite/poly(vinyl alcohol)/chitosan/gentamicin coating for biomedical applications

“…27,29,33,39,40 Due to its numerous advantages (e.g., uniform composition and thickness of the deposited coatings, the possibility of deposition on substrates of complex geometries found in orthopedics, low degree of environmental pollution, and room temperature processing, which is crucial for deposition of bioceramic coatings containing thermolabile antibacterial agents) 41 electrophoretic deposition (EPD) was chosen for the production of biocomposite coatings loaded with Gent. [41][42][43][44][45] Electrophoretic deposition of composite coatings containing chitosan and gentamicin (along with methyl-cellulose, 46 gelatin and bioactive glass, 47 gelatin, silica-gentamicin and bioactive glass, 48 hydroxyapatite 49 , etc.) has been reported in the literature.…”

“…Gentamicin could be introduced into the composite coatings by pre-loading 48,50 or in a single-step process. 46,47,49 In this research, we represent novel results dealing with biocompatibility and antibacterial properties, as well as bioactivity and mathematical modeling of the gentamicin release from a composite coating of unique composition, i.e., hydroxyapatite/poly(vinyl alcohol)/chitosan/gentamicin, obtained from a four-component aqueous suspension by single-step electrophoretic deposition. The formation of organosolvent-free biocompatible composite coatings deposited from aqueous suspension is especially advantageous due to the potential applications in reconstructive surgery where local drug administration is needed.…”