Mucoepidermoid/Adenosquamous Carcinoma of the Skin: Presentation of Two Cases

Johnson, Darlene S.; Solomon, Alvin R.; Washington, Carl V.

doi:10.1046/j.1524-4725.2001.00152.x

Cited by 18 publications

(32 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MECis a distinct type of tumour, comprising epidermoid cells, mucus-secreting, and intermediate cells in various proportion [1,4,10,11] . It is most commonly found in the salivary glands, but has also been reported in the oral cavity, bronchi, oesophagus, thyroid or breasts [1-3, 5, 10] .…”

Section: Discussionmentioning

confidence: 99%

“…Mucoepidermoid carcinomas (MEC) was first established as a unique entity, which diagnostic features include squamous or epidermoid cells, basal or intermediate cells, and mucin-secreting cells, in 1945 by Steward et al by reviewing a series of 45 salivary gland tumour [1] . It most commonly arises from the salivary glands and accounts for 10%-30% of salivary gland tumour [1][2][3][4] .…”

Section: Introductionmentioning

confidence: 99%

“…It most commonly arises from the salivary glands and accounts for 10%-30% of salivary gland tumour [1][2][3][4] . Apart from the major salivary glands, MEC is also relatively commonly found in the oral cavity, especially the palate, presumably arising from minor salivary glands [5] .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Primary cutaneous mucoepidermoid carcinoma

Chan

et al. 2014

CRCP

View full text Add to dashboard Cite

Primary cutaneous mucoepidermoid carcinoma (MEC) is a rare disease entity. Only around 20 cases have been reported so far. Herein, we present two cases for better understanding of the condition: A 74-year-old lady with a low-grade primary cutaneous MEC at her right external auditory ear canal was treated with surgical resection and adjuvant radiotherapy. The patient developed recurrence five months later and succumbed. Another 81-year-old lady with a high-grade primary cutaneous MEC carcinoma on her left parietal scalp treated by excisional biopsy remained disease free for 10 years. Their histological slides were discussed in details. Current evidence in the literature was also reviewed and summarized.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Primary cutaneous mucoepidermoid carcinoma

Chan

et al. 2014

CRCP

View full text Add to dashboard Cite

show abstract

“…Malignant epithelial neoplasms arising in accessory lacrimal glands are extremely rare and present several challenges to both the pathologist and the treating clinician [1,2,3,4,5]. It may be difficult, if not impossible, to localize the tumor unequivocally to the accessory lacrimal gland in the absence of a well-defined in situ component.…”

Section: Introductionmentioning

confidence: 99%

“…Finally, since the biologic behavior of accessory lacrimal gland neoplasms is obscure, the optimal management of these lesions is not well defined. Several patients with well-documented adenoid cystic carcinoma and mucoepidermoid carcinoma of accessory lacrimal gland origin have been, thus far, described in the literature [1,2,3,4,5]. To our knowledge, there have been no prior reports of adenocarcinoma arising in this location.…”

Section: Introductionmentioning

confidence: 99%

Adenocarcinoma, Not Otherwise Specified, Arising in Accessory Lacrimal Gland: A Diagnostic Challenge

Milman

Iacob²,

Lauer

et al. 2017

Ocul Oncol Pathol

View full text Add to dashboard Cite

Neoplasms arising in accessory lacrimal glands are rare. We describe a 33-year-old man with adenocarcinoma arising in the left lower eyelid accessory lacrimal gland. Microscopic evaluation demonstrated an infiltrative neoplasm composed of mildly to moderately pleomorphic cells with abundant eosinophilic cytoplasm and focal intracytoplasmic vacuoles, arranged predominantly in ductules. Foci of luminal and intracytoplasmic eosinophilic secretory material and occasional mucin were noted. An in situ component was identified in the gland of Wolfring. Though perineural invasion was present, high-grade nuclear features, brisk mitotic activity, and comedonecrosis were not identified. Immunohistochemical studies were notable for immunoreactivity of the tumor cells for CK7, carcinoembryonic antigen, BRST-2, androgen receptors, and HER2/neu (2+). The neoplastic cells were negative for CK20, estrogen and progesterone receptors, S-100, p63, calponin, thyroid transcription factor-1, and prostate-specific antigen. Fluorescence in situ hybridization studies for ETV6 and MAML2 rearrangements and for HER2/neu amplification were negative. Because of the absence of unifying morphologic, immunophenotypic, and molecular genetic findings, the diagnosis of adenocarcinoma, not otherwise specified, was rendered. The patient underwent comprehensive oncologic workup, which was negative for another primary tumor and metastases. He remains disease free with a follow-up of 4 years. This case illustrates the challenges encountered in applying salivary gland tumor classification to the accessory lacrimal gland neoplasm.

show abstract