Mucormycosis with pulmonary, renal, pancreatic and spleen involvement detected by 18F-FDG PET/CT in a patient who underwent allogeneic stem cell transplantation. Report of case

Abstract

Mucormycosis is a rare life-threatening opportunistic infection caused by mycetes of the order Mucoraceae. It appears mainly in immunocompromised patients (hematologic malignancies, anemia, AIDS) and in cases of advanced diabetes. A delayed diagnosis may imply a worse prognosis, so an early detection is mandatory for an adequate treatment. Herein we present a rare case of multi-organ mucormycosis with pulmonary, renal, pancreatic and spleen involvement detected and assessed by 18 F-FDG PET/CT in a 24-years-old woman diagnosed of grey zone lymphoma (DLCBL/HL) who underwent an allogeneic stem cell transplantation. PET/CT with 18F-FDG was a key element in biopsy guide, final diagnosis and monitoring of response to therapy.

COVID-19 associated mucormycosis: evolving technologies for early and rapid diagnosis

“…In addition to anatomic imaging modalities, functional and metabolic imaging using (PET/CT) coupled with [18F]-fluorodeoxyglucose (FDG) has been considered a valuable tool in the diagnosis and management of mucormycosis. Several reports have demonstrated an increased FDG uptake at the site of lesion upon diagnosis with FDG PET/CT during mucormycosis, and after antifungal therapy, the FDG uptake was reduced at the infection site (Dang et al 2012 ; Liu et al 2013 ; G Díaz et al 2019 ; Song 2019 ; Gallo et al 2019 ). Currently there are no reports supporting use of any particular technique in diagnosis of CAM.…”