Müller (glial) cells in the retina of urodeles and anurans reveal different morphology by means of freeze-fracturing

Wolburg, Hartwig; Emde, Karin Berg-von der; Naujoks-Manteuffel, Christiane

doi:10.1016/0304-3940(92)90479-q

Cited by 7 publications

(7 citation statements)

References 20 publications

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“…The vitread endfoot membranes of all studied vertebrates (except anurans) were shown to express orthogonal arrays of membrane particles (OAP; Reale et al, 1974;Wolburg and Berg, 1988;Richter et al, 1990;Wolburg et al, 1992). Thus, it was no surprise to observe OAF' in replicas of tree shrew Miiller cell endfoot membranes.…”

Section: U1 Trastructurementioning

confidence: 92%

Müller glial cells of the tree shrew retina

Reichenbach

Frömter

Engelmann

et al. 1995

J of Comparative Neurology

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The tree shrew is one of the few mammalian species whose retinae are strongly cone dominated, which is usually the case in reptilian and avian retinae. Müller cells of the tree shrew (Tupaia belangeri) retina were studied by transmission electron microscopy of tissue sections and freeze-fracture replicas, by immunolabeling of the intermediate filament protein vimentin in radial paraffin sections and in whole retinae, as well as by intracellular dye injection in slices of retinae. In addition, enzymatically isolated cells were stained by Pappenheim's panoptic staining method. The cells showed an ultrastructure that is similar to other mammalian Müller cells with two exceptions: Due to the extensive lateral fins of cone inner segments, the apical microvilli of Müller cells are arranged in peculiar palisades, and the basket-like Müller cell sheaths around neuronal somata in both nuclear layers consist of unusual multilayered membrane lamellae. Unlike Müller cells in other mammalian species studied thus far, but similar to reptilian and avian Müller cells, those of tree shrews commonly have two or more vitread processes rather than one main trunk. Müller cell densities range between some 13,000 mm-2 in the periphery and about 20,000 mm-2 in the retinal center. Neuron:(Müller)glial cell ratios were estimated to be 7.9:1 in the center and 6.2:1 in the periphery. For each Müller cell, about 1.5 (cone) photoreceptor cells, four or five interneurons of the inner nuclear layer, and about one cell of the ganglion cell layer were counted. This is a much lower number of neurons per Müller cell than in most other mammals studied.

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Section: U1 Trastructurementioning

confidence: 92%

Müller glial cells of the tree shrew retina

Reichenbach

Frömter

Engelmann

et al. 1995

J of Comparative Neurology

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“…Although one may assume that most of the physiological mechanisms are similar in Mü ller cells from urodeles and anurans, there might be also differences between the two groups in respect to membrane physiology. For example, such differences may be due to the lack of orthogonal arrays of particles in frog Mü ller cells (Wolburg et al, 1992) as these structures were shown to be constituted by aquaporin-4 water channels Rash et al, 1998;Yang et al, 1996) and perhaps by K ϩ channels (Nagelhus et al, 1999). Furthermore, the stalk processes of Mü ller cells from urodeles are much thicker than those of anuran Mü ller cells.…”

Section: Membrane Physiologymentioning

confidence: 94%

“…It is also notheworthy that the frog retina is overlaid by supraretinal (i.e., intravitreal) blood vessels; this corresponds to an accumulation of mitochondria in the Mü ller cell endfeet (Uga and Smelser, 1973). Finally, it is pointed out that Mü ller cell endfoot membranes in frogs (Rana esculenta and Xenopus laevis) lack the so-called orthogonal arrays of particles, while such membranes express these particles in all other vertebrates investigated, including urodeles (Wolburg et al, 1992;Wolburg, 1995).…”

Section: Anuran Mü Ller Cellsmentioning

confidence: 98%

M�ller glial cells in anuran retina

Bringmann

Skatchkov

Pannicke

et al. 2000

Microsc. Res. Tech.

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“…The existence of functional gap junctional coupling has been demonstrated by dye injection into Müller cells in the retina of Ambystoma mexicanum (Mobbs et al, ), connexin43 was identified in Necturus maculosus (Ball and McReynolds, ) and Cynops pyrrhogaster (Japanese fire belly newt) (Umino and Saito, ). An interesting result has been described by Wolburg et al (): Orthogonal arrays of particles have been found in species from the group Urodela , but not from the group Anura . See [Table (Part B)] for a comprehensive overview of data from amphibian Müller cells.…”

Section: Amphibiansmentioning

confidence: 99%

Comparative electrophysiology of retinal Müller glial cells—A survey on vertebrate species

Pannicke

Chao²,

Reisenhofer

et al. 2016

Glia

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Müller cells are the dominant macroglial cells in the retina of all vertebrates. They fulfill a variety of functions important for retinal physiology, among them spatial buffering of K ions and uptake of glutamate and other neurotransmitters. To this end, Müller cells express inwardly rectifying K channels and electrogenic glutamate transporters. Moreover, a lot of voltage- and ligand-gated ion channels, aquaporin water channels, and electrogenic transporters are expressed in Müller cells, some of them in a species-specific manner. For example, voltage-dependent Na channels are found exclusively in some but not all mammalian species. Whereas a lot of data exist from amphibians and mammals, the results from other vertebrates are sparse. It is the aim of this review to present a survey on Müller cell electrophysiology covering all classes of vertebrates. The focus is on functional studies, mainly performed using the whole-cell patch-clamp technique. However, data about the expression of membrane channels and transporters from immunohistochemistry are also included. Possible functional roles of membrane channels and transporters are discussed. Obviously, electrophysiological properties involved in the main functions of Müller cells developed early in vertebrate evolution. GLIA 2017;65:533-568.

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Müller (glial) cells in the retina of urodeles and anurans reveal different morphology by means of freeze-fracturing

Cited by 7 publications

References 20 publications

Müller glial cells of the tree shrew retina

Müller glial cells of the tree shrew retina

M�ller glial cells in anuran retina

Comparative electrophysiology of retinal Müller glial cells—A survey on vertebrate species

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