Müller glial cells of the primate foveola: An electron microscopical study

Syrbe, Steffen; Kuhrt, Heidrun; Gärtner, Ulrich; Habermann, Gunnar; Wiedemann, Peter; Bringmann, Andreas; Reichenbach, Andreas

doi:10.1016/j.exer.2017.12.004

Cited by 73 publications

(111 citation statements)

References 32 publications

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“…The basal lamina of the ILM is very thin in the foveola (30–40 nm) and thick in the foveal walls (0.9–1.0 μm) (Figure d) (Henrich et al, ; Syrbe et al, ). The somata of the foveolar Müller cells lie in the inner layer of the foveola (Figures b and c,e,g) (Reichenbach & Bringmann, ).…”

Section: Müller Cells Of the Foveamentioning

confidence: 99%

“…The foveola is composed of cone photoreceptor and Müller cells (Polyak, ; Yamada, ). 25–35 specialized Müller cells (Figure i) form an inverted cone‐like structure in the foveola, the “Müller cell cone” (Figures b and a) (Gass, ; Reichenbach & Bringmann, ; Syrbe et al, ; Yamada, ). The horizontal layer of the Müller cell cone forms the inner layer of the foveola, and the vertical stalk of the Müller cell cone is localized in the center of the foveola (Figures b and b).…”

Section: Müller Cells Of the Foveamentioning

confidence: 99%

“…CHO, choriocapillaris; GCL, ganglion cell layer; INL, inner nuclear layer; IPL, inner plexiform layer; NFL, nerve fiber layer; OPL, outer plexiform layer; PRS, photoreceptor segments; RPE, retinal pigment epithelium. Images modified after Babbitt (), Reichenbach and Bringmann (), and Syrbe et al ()…”

Section: Müller Cells Of the Foveamentioning

confidence: 99%

“…The somata of the foveolar Müller cells lie in the inner layer of the foveola (Figures b and c,e,g) (Reichenbach & Bringmann, ). The somata extend numerous thin lamelliform and tubular inner processes which form an elaborated plait which spreads along and below the basal lamina of the ILM and thus covers the vitreal surface of the foveola and the transition zone between the foveola and foveal walls (Figure e) (Syrbe et al, ). Thin Müller cell processes also cover the basal lamina in the foveal walls (Figure d).…”

Section: Müller Cells Of the Foveamentioning

confidence: 99%

“…The inner processes of foveolar Müller cells are often very thin, with a thickness similar to that of the basal lamina (Figure e). The cytoplasm of Müller cells in the inner layer of the foveola is densely packed with smooth endoplasmic reticulum (Syrbe et al, ), likely to produce secretory proteins like components of the basal lamina. The spaces between the inner Müller cell processes are commonly very narrow, but at many locations, they are expanded and form watery cysts (Figure c–e) (Syrbe et al, ).…”

Section: Müller Cells Of the Foveamentioning

confidence: 99%

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Glia of the human retina

Reichenbach

Bringmann

2019

Glia

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The human retina contains three types of glial cells: microglia and two types of macroglia, astrocytes and Müller cells. Macroglia provide homeostatic and metabolic support to photoreceptors and neurons required for neuronal activity. The fovea, the site of the sharpest vision which is astrocyte‐ and microglia‐free, contains two populations of Müller glia: cells which form the Müller cell cone in the foveola and z‐shaped Müller cells of the foveal walls. Both populations are characterized by morphological and functional differences. Müller cells of the foveola do not support the activity of photoreceptors and neurons, but provide the structural stability of the foveal tissue and improve the light transmission through the tissue to the photoreceptors. This article gives overviews of the glia of the human retina and the structure and function of both Müller cell types in the fovea, and describes the contributions of astrocytes and Müller cells to the ontogenetic development of the fovea.

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Section: Müller Cells Of the Foveamentioning

confidence: 99%

Section: Müller Cells Of the Foveamentioning

confidence: 99%

Section: Müller Cells Of the Foveamentioning

confidence: 99%

Section: Müller Cells Of the Foveamentioning

confidence: 99%

Section: Müller Cells Of the Foveamentioning

confidence: 99%

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Glia of the human retina

Reichenbach

Bringmann

2019

Glia

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220

159

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Retinal regions shape human and murine Müller cell proteome profile and functionality

Kaplan

Drexler

Pfaller

et al. 2022

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The human macula is a highly specialized retinal region with pit-like morphology and rich in cones. How Müller cells, the principal glial cell type in the retina, are adapted to this environment is still poorly understood. We compared proteomic data from cone-and rod-rich retinae from human and mice and identified different expression profiles of cone-and rod-associated Müller cells that converged on pathways representing extracellular matrix and cell adhesion. In particular, epiplakin (EPPK1), which is thought to play a role in intermediate filament organization, was highly expressed in macular Müller cells. Furthermore, EPPK1 knockout in a human Müller cell-derived cell line led to a decrease in traction forces as well as to changes in cell size, shape, and filopodia characteristics. We here identified EPPK1 as a central molecular player in the region-specific architecture of the human retina, which likely enables specific functions under the immense mechanical loads in vivo.

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