Müllerianosis of the Ureter: A Metaplastic Lesion

Nogales, Francisco F.; Zuluaga, Armando; Arrabal, Miguel; Dhakal, Hari Prasad; Aguilar, David

doi:10.1016/s0022-5347(05)68111-6

Cited by 17 publications

(7 citation statements)

References 2 publications

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“…This has been aptly called the secondary Müllerian system (Lauchlan et al, 1994), which is not restricted to the peritoneum, but also present in the urinary bladder (Donne et al, 1998), ureter (Nogales et al, 1999), pleura and even in the abdominal and axillary lymph nodes (Stolnicu et al, 2011).…”

Section: Multifocal Peritoneal Metaplasia Induced By Growth Factorsmentioning

confidence: 99%

Gliomatosis peritonei as a natural experiment in tissue differentiation

Nogales¹,

Preda²,

Dulcey³

2012

Int. J. Dev. Biol.

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Gliomatosis peritonei (GP) is an unusual condition in which nodules of mature astroglia, often miliary and microscopic in size, are widespread in the peritoneum and abdominal lymph nodes. Its behaviour is benign and it is usually found in association with ovarian teratoma and rarely with teratomas of other organs. Implants grow rapidly and can remain unchanged for life. Astroglia is the main component, but other neural lineage elements and many other tissues can be found. Cells are mature but not terminal, since they express SOX2. Secondary associated lesions include: a) degenerative astrocytic changes, b) granulomatous and follicular chronic inflammatory changes, c) association with hormonally related changes, such as decidual peritoneal metaplasia and endometriosis and d) endothelial and adventitial vascular hyperplasia leading to haemoperitoneum. Two pathogenetic mechanisms are considered: direct seeding of immature neural cells from a primary tumour with subsequent differentiation and metaplasia from peritoneal stem cells. The former proposal is supported by clinicopathologic data such as ample cellular heterogeneity, coexistence of mature astroglia with neural blastema, as well as the shed keratin and hairs from the ovarian neoplasm. However, metaplasia is sustained by a heterozygosity pattern of GP nodules, identical to the normal tissue and different from the coexistent ovarian teratoma. GP would constitute a response to growth factors from teratoma or macrophages. While an implantative origin from ovarian teratoma remains in most cases a more probable mechanism, metaplasia from peritoneal stem cells would explain cases of GP which present a monomorphic astrocytic cell population.

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Section: Multifocal Peritoneal Metaplasia Induced By Growth Factorsmentioning

confidence: 99%

Gliomatosis peritonei as a natural experiment in tissue differentiation

Nogales¹,

Preda²,

Dulcey³

2012

Int. J. Dev. Biol.

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“…Fewer than a dozen cases of Mullerianosis of the urinary bladder have been reported 1–5, 7–10. The major clinical and histopathological features are summarized in Table I.…”

Section: Discussionmentioning

confidence: 99%

“…Mullerianosis of the urinary bladder is a rare entity characterized by the presence of an admixture of at least two types of mullerian tissue—endocervicosis, endosalpingiosis, and endometriosis in the muscularis propria of the bladder 1. Fewer than 20 cases of mullerianosis of the urinary bladder have been reported,1–10 and only one of these cases had cytological description in a urine specimen 4. We report a case of mullerianosis of the urinary bladder with the diagnosis first suggested in a urine cytopathology report.…”

mentioning

confidence: 95%

Mullerianosis of the urinary bladder: Report of a case with diagnosis suggested in urine cytology and review of literature

Guan¹,

Rosenthal²,

Erozan³

2011

Diagnostic Cytopathology

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Mullerianosis of the urinary bladder is a rare entity characterized by the presence of an admixture of at least two types of mullerian tissue in the muscularis propria of the bladder. We report a case of mullerianosis of the urinary bladder in a 28-year-old nulliparous woman with no history of pelvic surgery or endometriosis, and the diagnosis of mullerianosis was suggested initially in urine cytopathology report. In this study, previously reported cases of mullerianosis of urinary bladder are reviewed, and differential diagnosis of endometrial-like cells in the urine has been discussed. Fewer than 20 cases of mullerianosis of the urinary bladder have been reported in the literature, and only one of these cases had cytological description in a urine specimen. Most of patients were of reproductive age ranging from 28 to 53 years and had no previous history of pelvic surgery or Cesarean section. The clinical presentations frequently were abdominal/pelvic pain and dysuria/hematuria, which may or may not be associated with menstruation. Radiologic study revealed polypoid, mass-like lesion ranging from 1 to 4.5 cm in size, predominantly involving the dome or posterior wall of the bladder. Histological sections showed two or more of the three related benign mullerian glandular epithelial proliferations-endometriosis, endosalpingiosis, and endocervicosis. Most of the patients have good prognosis with medical management.

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“…2 Both cases of ureteral mullerianosis in the urologic literature were diagnosed after ureteral resection. 3,4 Using ureteroscopy and biopsy to diagnosis this benign (as well as rare) condition is useful to avoid unnecessary invasive surgical procedures. …”

Section: Discussionmentioning

confidence: 99%