Multi-biofunction of antimicrobial peptide-immobilized silk fibroin nanofiber membrane: Implications for wound healing

Electrospun nanofibrous materials for wound healing applications

“…The fibrous membrane also facilitated proliferation of keratinocytes and fibroblasts. Further, it suppressed the lipopolysaccharides (LPS)-induced TNF-a expression of monocytes, suggesting as a promising candidate in wound dressing application [40].…”

Recent developments in drug-eluting dressings for the treatment of chronic wounds

“…AMP is an interesting approach for chronic infectious wound treatment. The immobilization of AMP motif Cys-KR12 on silk fibroin nanofiber membrane showed not only antimicrobial property but also enabled cell proliferation, keratinocyte differentiation and also enabled the inhibition of inflammatory cytokine production and thereby enhances the rate of wound healing [9].…”

A Review of Injectable and Implantable Biomaterials for Treatment and Repair of Soft Tissues in Wound Healing

“…In addition, collagen fibers appeared to increase wound closure rate significantly even when comparing to those subjected to commercially available dressing materials, Kaltostat. Furthermore, studies showed the immobilization of the peptide motif (Cys-KR12) on silk fibroin nanofibers and suggested a strong antimicrobial effect to several pathogenic bacterial strains [69]. Moreover, chitosan and poly(ethylene oxide) (PEO) blend solutions were electrospun into fibers to incorporate vascular endothelial growth factor (VEGF) while platelet-derived growth factor-BB (PDGF-BB) was encapsulated in poly(lactic-co-glycolic acid) (PLGA) nanoparticles and further loaded in nanofibers during electrospinning process [70].…”