Multi‐Caged IrO<i><sub>x</sub></i> for Facile Preparation of “Six‐in‐One” Nanoagent for Subcutaneous and Lymphatic Tumors Inhibition against Recurrence and Metastasis

Zhen, Wenyao; Liu, Yang; Zhang, Mengchao; Hu, Wenxue; Wang, Wei; Jia, Xiaodan; Jiang, Xiue

doi:10.1002/adfm.202002274

Cited by 27 publications

(11 citation statements)

References 65 publications

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“…Both Ce6 and IrO 2 have been reported to generate singlet oxygen ( 1 O 2 ) under US stimulation. [38,39] We measured the SDT performance of HC, HIr, and HCIr with DPBF, which was the 1 O 2 probe (Figure 2h). After 10 min of US stimulation (1.0 W cm −2 , 1.0 MHz, 50% duty cycle), the absorbance of DPBF in the HC solution dropped to 63.9% at 410 nm, and it dropped to 76.4% in the HIr solution, and in the HCIr solution it dropped to 45.7%, while the absorbance of the PBS group did not change significantly.…”

Section: In Vitro Sdt Effects and Gsh Depletion Ability Of Hcir Nanoc...mentioning

confidence: 99%

Bioactive Iridium Nanoclusters with Glutathione Depletion Ability for Enhanced Sonodynamic‐Triggered Ferroptosis‐Like Cancer Cell Death

et al. 2022

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Section: In Vitro Sdt Effects and Gsh Depletion Ability Of Hcir Nanoc...mentioning

confidence: 99%

Bioactive Iridium Nanoclusters with Glutathione Depletion Ability for Enhanced Sonodynamic‐Triggered Ferroptosis‐Like Cancer Cell Death

et al. 2022

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“…Because of the ultrasmall size and the high dispersion of the Ir NCs inside BOD-Ir NCs, no characteristic peaks of Ir were detected in its XRD pattern (Figure S2). 33,34 XPS showed characteristic peaks of Ir−N (399.3 eV) and Ir−O (531.0 eV) (Figure 1e). 35,36 Considering that BOD is the only source of N and O in the reaction system, it can be concluded that BOD formed chemical bonds with the Ir NCs, which were highly helpful in stabilizing Ir NCs.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

General Synergistic Hybrid Catalyst Synthesis Method Using a Natural Enzyme Scaffold-Confined Metal Nanocluster

Liu

Zhang

et al. 2022

ACS Appl. Mater. Interfaces

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Due to differences in the chemical properties or optimal reaction conditions of the catalysts, the challenge in the design of bio-chemical hybrid catalysts is that the bio-catalysts or chemical catalysts usually cannot maintain the initial catalytic performance. Herein, we report a general bio-chemical hybrid catalyst synthesis method using a natural enzyme scaffold-confined metal nanocluster. A redox-active enzyme is a nanoreactor that allows access to and reduces metal ions into metal nanoclusters in situ, resulting in the enzyme-confined metal nanocluster hybrid catalyst with a synergistic effect to boost catalytic performance. Specifically, bilirubin oxidase-Ir nanoclusters (BOD-Ir NCs) with catalytic properties for the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) are designed. The BOD-Ir NCs exhibit an approximately 2-fold ORR activity compared with pure BOD and a 4-fold OER activity compared with pure Ir NCs. BOD-Ir NCs exhibit stability for over 50,000 s, exceeding that of pure Ir NCs (22,000 s). The synergistic catalytic performance is attributed to the following: the mild preparation condition and matched sizes of BOD and the Ir NCs maintain the natural activity of BOD; the highly conductive Ir NCs improve the ORR activity of BOD; and the confining effect of BOD, which improves the stability and activity of the Ir NCs during the OER. In particular, BOD-Ir NCs exhibit a high half-wave potential of 0.97 V for the ORR and a low overpotential of 319 mV at 10 mA cm −2 for the OER, surpassing most of reported catalysts under neutral conditions. Furthermore, laccase-Ir NCs and glucose oxidase-Pd NCs with synergistic catalytic performances are fabricated, proving the universality of this synthetic method. This facile strategy for designing synergistic hybrid catalysts is expected to be applied to more complex chemical transformations.

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“…Very recently, Zhen et al developed a "six-in-one" nanoplatform for multimodal imaging-guided and O 2 enhanced SDT/PDT/chemotherapy synergetic cancer therapy (Figure 22). [138] The multicaged IrO x nanocarriers were first fabricated using a thermal hydrolysis strategy. The group further demonstrated the catalase-like, PDT, and SDT activity of IrO x .…”

Section: Trimodal Synergistic Therapy Based On Sonodynamic Therapymentioning

confidence: 99%

Recent Advances in Nanomaterial‐Assisted Combinational Sonodynamic Cancer Therapy

et al. 2020

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Ultrasound (US)-triggered sonodynamic therapy (SDT), as a promising noninvasive therapeutic modality, has received ever-increasing attention in recent years. Its specialized chemical agents, named sonosensitizers, are activated by low-intensity US to produce lethal reactive oxygen species (ROS) for oncotherapy. Compared with phototherapeutic strategies, SDT provides many noteworthy opportunities and benefits, such as deeper penetration depth, absence of phototoxicity, and fewer side effects. Nevertheless, previous studies have also demonstrated its intrinsic limitations. Thanks to the facile engineering nature of nanotechnology, numerous novel nanoplatforms are being applied in this emerging field to tackle these intrinsic barriers and achieve continuous innovations. In particular, the combination of SDT with other treatment strategies has demonstrated a superior efficacy in improving anticancer activity relative to that of monotherapies alone. Therefore, it is necessary to summarize the nanomaterial-assisted combinational sonodynamic cancer therapy applications. Herein, the design principles in achieving synergistic therapeutic effects based on nanomaterial engineering methods are highlighted. The ultimate goals are to stimulate the design of better-quality combined sonodynamic treatment schemes and provide innovative ideas for the perspectives of SDT in promoting its future transformation to clinical application.

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Multi‐Caged IrO_x for Facile Preparation of “Six‐in‐One” Nanoagent for Subcutaneous and Lymphatic Tumors Inhibition against Recurrence and Metastasis

Cited by 27 publications

References 65 publications

Bioactive Iridium Nanoclusters with Glutathione Depletion Ability for Enhanced Sonodynamic‐Triggered Ferroptosis‐Like Cancer Cell Death

Bioactive Iridium Nanoclusters with Glutathione Depletion Ability for Enhanced Sonodynamic‐Triggered Ferroptosis‐Like Cancer Cell Death

General Synergistic Hybrid Catalyst Synthesis Method Using a Natural Enzyme Scaffold-Confined Metal Nanocluster

Recent Advances in Nanomaterial‐Assisted Combinational Sonodynamic Cancer Therapy

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Multi‐Caged IrOx for Facile Preparation of “Six‐in‐One” Nanoagent for Subcutaneous and Lymphatic Tumors Inhibition against Recurrence and Metastasis

Cited by 27 publications

References 65 publications

Bioactive Iridium Nanoclusters with Glutathione Depletion Ability for Enhanced Sonodynamic‐Triggered Ferroptosis‐Like Cancer Cell Death

Bioactive Iridium Nanoclusters with Glutathione Depletion Ability for Enhanced Sonodynamic‐Triggered Ferroptosis‐Like Cancer Cell Death

General Synergistic Hybrid Catalyst Synthesis Method Using a Natural Enzyme Scaffold-Confined Metal Nanocluster

Recent Advances in Nanomaterial‐Assisted Combinational Sonodynamic Cancer Therapy

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Multi‐Caged IrO_x for Facile Preparation of “Six‐in‐One” Nanoagent for Subcutaneous and Lymphatic Tumors Inhibition against Recurrence and Metastasis