The initial assessment of skin lesions is typically based on dermoscopic images. As this is a difficult and timeconsuming task, machine learning methods using dermoscopic images have been proposed to assist human experts. Other approaches have studied electrical impedance spectroscopy (EIS) as a basis for clinical decision support systems. Both methods represent different ways of measuring skin lesion properties as dermoscopy relies on visible light and EIS uses electric currents. Thus, the two methods might carry complementary features for lesion classification. Therefore, we propose joint deep learning models considering both EIS and dermoscopy for melanoma detection. For this purpose, we first study machine learning methods for EIS that incorporate domain knowledge and previously used heuristics into the design process. As a result, we propose a recurrent model with state-max-pooling which automatically learns the relevance of different EIS measurements. Second, we combine this new model with different convolutional neural networks that process dermoscopic images. We study ensembling approaches and also propose a cross-attention module guiding information exchange between the EIS and dermoscopy model. In general, combinations of EIS and dermoscopy clearly outperform models that only use either EIS or dermoscopy. We show that our attention-based, combined model outperforms other models with specificities of 34.4 % ) and 53.7 % (CI 50.1-57.6) for dermoscopy, EIS and the combined model, respectively, at a clinically relevant sensitivity of 98 %.Recently, other automatic diagnosis methods have been proposed using dermoscopic images as an input to convolutional neural networks (CNNs). 7, 8 Also, the ISIC 2018 Skin Lesion Analysis Towards Melanoma Detection Challenge 9 resulted in numerous deep learning-based methods for high-performance skin lesion classification. 10 So far, machine learning methods for EIS and dermoscopy have been addressed separately, although dermoscopic images are generally acquired before EIS measurements. 3 EIS and dermoscopy represent very different ways of measuring skin lesion properties. While dermoscopy captures light absorption mostly at the skin surface, EIS provides electrical resistance properties in deeper skin layers. Thus, the two methods might complement each