A multi-objective optimization method is presented in this paper, aiming at improving the fatigue life of the engine hood while achieving light weight. By analyzing the factors affecting the fatigue life of the engine hood, a multi-objective optimization model was established that considered five design variables including the thickness of the inner plate, the thickness of the outer plate, the stiffness of the hook, the stiffness of the sealing strip, and the height of the buffer block. Then, the multi-objective particle swarm method was used for optimization, and the optimal solution was obtained in the form of a Pareto set. The ideal compromise solution was determined from the Pareto set by using fuzzy membership functions. On this basis, the optimal solution was determined from the Pareto set by comprehensively considering the steel plate material specification, mold and cost constraints. The torsional deformation test and switch fatigue test show that for the optimized engine hood, the fatigue life is increased by 117%, the mass is reduced by 0.51 kg, and the torsional deformation of the engine hood does not increase significantly. The proposed multi-objective optimization method is proved to be feasible and effective in improving engine hood fatigue life and lightweight design.