“…The last 35 years have brought major advancements in the size and complexity of flow sheets, the incorporation of thermodynamic models, numerical solutions, and graphical user interfaces . By now, there are also numerous interactions between operations research for optimal planning and scheduling of chemical sites , product changeover for batch productions as well as real‐time optimization with large‐scale process simulation tasks . However, up to now, really challenging process simulation and process optimization tasks, e.g., of systems with complex electrolytes and reactions, are seldom carried out in the same tool or programming language: instead either sequential optimization schemes are commonly set up or surrogate models are developed based on rigorous simulations, which are then implemented as part of the optimization problem .…”