Multi-Probiotics ameliorate Major depressive disorder and accompanying gastrointestinal syndromes via serotonergic system regulation

Tian, Peijun; Zou, Renying; Wang, Luyao; Chen, Ying; Qian, Xin; Zhao, Jianxin; Zhang, Hao; Qian, Long; Wang, Qun; Wang, Gang; Chen, Wei

doi:10.1016/j.jare.2022.05.003

Cited by 51 publications

(21 citation statements)

References 44 publications

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“…The phylum Actinobacteria , which consists of Gram-positive, branched, non-motile, non-spore-forming microorganisms, is the least predominant at the intestinal level and is represented by the genus Bifidobacterium [ 23 ] and plays a vital role in the colonisation of the digestive tract of children born by vaginal delivery, conversely, it is significantly less in those born by cesarean section [ 24 ]. On the other hand, the phylum Bacteroidetes is composed of Gram-negative bacteria of Bacteroides and Prevotella genera [ 20 ], playing as primary polysaccharide processors [ 25 ] and whose final products are substrates for enzymes from other bacterial genera that eventually participate in the immune system regulation [ 26 ], intermediary metabolism [ 27 ] and intestinal–brain axis signalling [ 28 , 29 , 30 ]. Bacteria such as Lactobacillus (Firmicutes) and Bifidobacterium (Actinobacteria) hydrolyse and ferment very specific polysaccharides to produce the short-chain fatty acids (SCFA) acetate, butyrate, and propionate ( Figure 1 ) [ 31 ].…”

Section: Structure Of the Human Gut Microbiotamentioning

confidence: 99%

Probiotics and Gut Microbiota in Obesity: Myths and Realities of a New Health Revolution

Aguilera

Manzano

Pirela

et al. 2022

JPM

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Obesity and its comorbidities are humans’ most prevalent cardio-metabolic diseases worldwide. Recent evidence has shown that chronic low-grade inflammation is a common feature in all highly prevalent chronic degenerative diseases. In this sense, the gut microbiota is a complete ecosystem involved in different processes like vitamin synthesis, metabolism regulation, and both appetite and immune system control. Thus, dysbiosis has been recognised as one of the many factors associated with obesity due to a predominance of Firmicutes, a decrease in Bifidobacterium in the gut, and a consequent short-chain fatty acids (SCFA) synthesis reduction leading to a reduction in incretins action and intestinal permeability increase. In this context, bacteria, bacterial endotoxins, and toxic bacterial by-products are translocated to the bloodstream, leading to systemic inflammation. This review focuses on gut microbiota composition and its role in obesity, as well as probiotics and prebiotics benefits in obesity.

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Section: Structure Of the Human Gut Microbiotamentioning

confidence: 99%

Probiotics and Gut Microbiota in Obesity: Myths and Realities of a New Health Revolution

Aguilera

Manzano

Pirela

et al. 2022

JPM

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“…Accumulating evidence demonstrated that probiotics exerted various beneficial effects including improvement in the health of intestinal tract, enhancement of immune system, reduction of intestinal disorders [13,14].…”

Section: Introductionmentioning

confidence: 99%

Lactobacillus plantarum AR113 attenuates liver injury in D-galactose-induced aging mice via the inhibition of oxidative stress and endoplasmic reticulum stress

Xia¹,

Gong²,

Lin³

et al. 2024

Food Science and Human Wellness

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Probiotics could effectively eliminate excess ROS generated during aging or lipid metabolism disorders, but their mechanism is unclear. The major purpose of this study was to investigate the mechanism of L. plantarun AR113 alleviating oxidative stress injury in the D-galactose induced aging mice. The result showed that pretreatment with L. plantarun AR113 significantly relieving H 2 O 2 induced cytotoxicity in HepG2 cells by maintain cell membrane integrity and increasing antioxidant enzyme activities. In D-galactose induced aging mice, L. plantarun AR113 could significantly attenuate liver damage and inflammatory infiltration by promoting endogenous GSH synthesis and activating the Nrf2/Keap1 signaling pathway in mice, and increasing the expression of regulated phase II detoxification enzymes and antioxidant enzymes. Further analysis shown that gavage of L. plantarun AR113 could significantly reduce the expression of GRP78 and CHOP proteins, and promote the restoration of ER homeostasis, thereby activating cell anti-apoptotic pathways. These results were also confirmed in H 2 O 2 -treated HepG2 experiments. It indicated that L. plantarun AR113 could inhibit D-galactose-induced liver injury through dual inhibition of ER stress and oxidative stress. L. plantarun AR113 have good application potential in anti-aging and alleviating metabolic disorders.

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“…One clinical study of patients with AD demonstrated that the AD pathologies were negatively correlated with the abundance of the genera Akkermansia and Bifidobacterium [5]. Several studies on depression and AD have identified Akkermansia and Bifidobacterium as key microbial modulators [6][7][8]. The communication and biological systems involved in gut-brain connections are complex; one of the various routes by which the microbiome affects and mediates key brain processes in AD is via gut microbial metabolites [9].…”

Section: Introductionmentioning

confidence: 99%

Environmental enrichment in combination with Bifidobacterium breve HNXY26M4 intervention amplifies neuroprotective benefits in a mouse model of Alzheimer's disease by modulating glutamine metabolism of the gut microbiome

Zhu¹,

Guo²,

Zhao³

et al. 2024

Food Science and Human Wellness

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The gut microbiota-brain axis has emerged as a novel target for Alzheimer's disease (AD), a neurodegenerative disease characterised by behavioural and cognitive impairment. However, most previous microbiome-based intervention studies have focused on single factors and yielded only modest cognitive improvements. Here, we proposed a multidomain intervention strategy that combined Bifidobacterium breve treatment with environmental enrichment (EE) training. In this study, we found that compared with EE or B. breve treatment alone, B. breve intervention combined with EE amplified its neuroprotective effects on AD mice, as reflected by improved cognition, inhibited neuroinflammation and enhanced synaptic function. Moreover, using microbiome and metabolome profiling, we found that the combination of B. breve and EE treatment restored AD-related gut microbiota dysbiosis and reversed microbial metabolite changes. Finally, by integrating behavioural and neurological data with metabolomic profiles, we revealed that the underlying mechanism may involve the modulation of microbiota-derived glutamine metabolism via gut-brain interactions. Collectively, combined B. breve intervention with EE treatment can alleviate AD-related cognitive impairment and improve brain function by regulating glutamine metabolism of the gut microbiome. Our findings provide a promising multidomain intervention strategy, with a combination of dietary microbiome-based and lifestyle-targeted interventions, to promote brain function and delay the progression of AD.

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Multi-Probiotics ameliorate Major depressive disorder and accompanying gastrointestinal syndromes via serotonergic system regulation

Cited by 51 publications

References 44 publications

Probiotics and Gut Microbiota in Obesity: Myths and Realities of a New Health Revolution

Probiotics and Gut Microbiota in Obesity: Myths and Realities of a New Health Revolution

Lactobacillus plantarum AR113 attenuates liver injury in D-galactose-induced aging mice via the inhibition of oxidative stress and endoplasmic reticulum stress

Environmental enrichment in combination with Bifidobacterium breve HNXY26M4 intervention amplifies neuroprotective benefits in a mouse model of Alzheimer's disease by modulating glutamine metabolism of the gut microbiome

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