Multi-walled carbon nanotubes/polypyrrole nanocomposite, synthesized through an eco-friendly route, as a prospective drug delivery system

Saheeda, P.; Thasneem, Y. M.; Sabira, K.; Dhaneesha, Mohandas; Sulfikkarali, N. K.; Jayaleksmi, S.

doi:10.1007/s00289-022-04290-3

Cited by 6 publications

(3 citation statements)

References 52 publications

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“…46 Cur showed three characteristic peaks at 1025, 1632, and 3505 cm −1 related to the stretching modes of the keto groups, the stretching vibrations of the benzene ring, and the phenolic O−H stretching vibration, respectively. 47 In the PA6/ PVA/CMWCNT-Cur spectrum, peaks at 1646 and 1725 cm −1 became slightly more intense than that of PA6/PVA, which can be related to the successful bonding between PVA hydroxyl groups and the carboxyl groups of CMWCNT. 48 The spectrum of PA6/PVA/CMWCNT-Cur was very similar to that of PA6/PVA, and the intensity of the peaks slightly increased due to their overlap.…”

Section: Resultsmentioning

confidence: 90%

“…The hydrogen bonding created by CO of PA6 and O–H of PVA increases the force between two molecular chains, causing PA6 and PVA to have strong compatibility, and the structure, morphology, and performance are reasonably stable . Cur showed three characteristic peaks at 1025, 1632, and 3505 cm –1 related to the stretching modes of the keto groups, the stretching vibrations of the benzene ring, and the phenolic O–H stretching vibration, respectively . In the PA6/PVA/CMWCNT-Cur spectrum, peaks at 1646 and 1725 cm –1 became slightly more intense than that of PA6/PVA, which can be related to the successful bonding between PVA hydroxyl groups and the carboxyl groups of CMWCNT .…”

Section: Resultsmentioning

confidence: 99%

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Drug-Loaded Carbon Nanotube Incorporated in Nanofibers: A Multifunctional Nanocomposite for Smart Chronic Wound Healing

Shakiba

Jahangiri

Rahmani

et al. 2023

ACS Appl. Polym. Mater.

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A proper dressing for chronic wounds should be able to preserve moisture while absorbing the exudates and exhibit good antibacterial properties and reliable mechanical properties. Furthermore, drug delivery through a wound dressing is an added value that brings more therapeutic and regenerative functionalities. In this study, a carboxylated multiwalled carbon nanotube–curcumin hybrid composite was embedded in a polyamide 6/poly(vinyl alcohol) nanofibrous composite (PA6/PVA/CMWCNT-Cur) for controlled drug release and potential wound healing application. PA6/PVA/CMWCNT-Cur nanofibrous composites were synthesized in two steps. First, Cur was loaded throughout the CMWCNT, and then a cross-linked PA6/PVA/CMWCNT-Cur blend solution was electrospun at CMWCNT-Cur concentrations of 0.5, 0.75, and 1 wt %. The results showed that incorporating PVA and CMWCNT-Cur into the PA6 nanofiber improved its wettability, physical properties, and biodegradability. In addition, the optical density technique demonstrated that the produced nanofibers had high antibacterial activity, which effectively inhibited the development of Staphylococcus aureus and Escherichia coli bacteria. Due to its uniform nanofibrous structure, superior mechanical capabilities, and excellent antibacterial features, the PA6/PVA/CMWCNT-Cur hybrid nanofibrous composite containing 0.75 wt % CMWCNT-Cur was chosen as the most suitable sample. Studies on the release of Cur from the nanofibers at different pH values demonstrated a faster rate in mild acidic media. The cell viability against the L929 cell line showed that the PA6/PVA/CMWCNT-Cur hybrid nanofibrous composite significantly increased the cell viability and proliferation. This work provides a simple and quick strategy for producing a multifunctional nanofibrous mat for wound healing applications.

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Section: Resultsmentioning

confidence: 90%

Section: Resultsmentioning

confidence: 99%

Drug-Loaded Carbon Nanotube Incorporated in Nanofibers: A Multifunctional Nanocomposite for Smart Chronic Wound Healing

Shakiba

Jahangiri

Rahmani

et al. 2023

ACS Appl. Polym. Mater.

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“…The research group of Saheeda [93] developed a smart nanocomposite of MWC-NTs with polypyrrole (PPy) via an eco-friendly route by using lemon fruit extract. This nanocomposite presented enhanced biocompatibility and low toxicity, and enhanced curcumin encapsulation of about 89%, and also exhibited pH dependent and sustained drug release over a prolonged period, offering great promise in drug delivery applications.…”

Section: Carbon Nanotubes (Cnts)mentioning

confidence: 99%

Organic and Biogenic Nanocarriers as Bio-Friendly Systems for Bioactive Compounds’ Delivery: State-of-the Art and Challenges

Petrovic,

Barbinta-Patrascu

2023

Materials

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“Green” strategies to build up novel organic nanocarriers with bioperformance are modern trends in nanotechnology. In this way, the valorization of bio-wastes and the use of living systems to develop multifunctional organic and biogenic nanocarriers (OBNs) have revolutionized the nanotechnological and biomedical fields. This paper is a comprehensive review related to OBNs for bioactives’ delivery, providing an overview of the reports on the past two decades. In the first part, several classes of bioactive compounds and their therapeutic role are briefly presented. A broad section is dedicated to the main categories of organic and biogenic nanocarriers. The major challenges regarding the eco-design and the fate of OBNs are suggested to overcome some toxicity-related drawbacks. Future directions and opportunities, and finding “green” solutions for solving the problems related to nanocarriers, are outlined in the final of this paper. We believe that through this review, we will capture the attention of the readers and will open new perspectives for new solutions/ideas for the discovery of more efficient and “green” ways in developing novel bioperformant nanocarriers for transporting bioactive agents.

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Design and fabrication of functionalized curdlan-curcumin delivery system to facilitate the therapeutic effects of curcumin on breast cancer

Ganie,

Naik,

Dar

et al. 2024

International Journal of Biological Macromolecules

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Multi-walled carbon nanotubes/polypyrrole nanocomposite, synthesized through an eco-friendly route, as a prospective drug delivery system

Cited by 6 publications

References 52 publications

Drug-Loaded Carbon Nanotube Incorporated in Nanofibers: A Multifunctional Nanocomposite for Smart Chronic Wound Healing

Drug-Loaded Carbon Nanotube Incorporated in Nanofibers: A Multifunctional Nanocomposite for Smart Chronic Wound Healing

Organic and Biogenic Nanocarriers as Bio-Friendly Systems for Bioactive Compounds’ Delivery: State-of-the Art and Challenges

Design and fabrication of functionalized curdlan-curcumin delivery system to facilitate the therapeutic effects of curcumin on breast cancer

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