Multicomponent synthetic strategies and perspectives for synthesis of linked or fused coumarin heterocycles

A novel coumarin-triazole-thiophene hybrid: synthesis, characterization, ADMET prediction, molecular docking and molecular dynamics studies with a series of SARS-CoV-2 proteins

“… 1 – 7 , 12 – 16 Thus, a combination of the coumarin, 1,2,4-triazole and thiophene functionalities in one molecule is of interest in terms of potential generating of novel biological properties, which, in turn, might be of great value against different diseases and for the design of new therapies, as well as for the design and fabrication of new materials of valuable properties. 17 …”

Cu(ii) immobilized on poly(guanidine-sulfonamide)-functionalized Bentonite@MgFe2O4: a novel magnetic nanocatalyst for the synthesis of 1,4-dihydropyrano[2,3-c]pyrazole

“…[7][8][9][10] In recent years, many publications based on MCRs have been reported, which emphasizes their highlighted applications in organic and medicinal chemistry. [11][12][13][14] 1,4-Dihydropyrano [2,3-c]pyrazole is a specic heterocyclic pharmacophore with diverse medicinal chemistry and several interesting pharmacological and therapeutic characteristics. [15][16][17][18] Moreover, it is used as the core moiety to prepare many well-known drugs having antifungal, anti-inammatory, antitumor, and several other pharmaceutical and bioorganic features (Fig.…”

“…7–10 In recent years, many publications based on MCRs have been reported, which emphasizes their highlighted applications in organic and medicinal chemistry. 11–14…”