Multidimensional gas chromatography beyond simple volatiles separation

Abstract

Multidimensional separation in gas chromatography (MDGC) plays an important role in chemical analysis. This review presents selected literature on MDGC development and examples of the range of functionality reported for MDGC methods over the past 2 decades. With the most obvious advantage of providing much greater capacity for resolving constituents of a sample, MDGC extends analytical efficiency to a more substantial molecular coverage, combined with operational flexibility. But by judicious choice of implementation method, important chemical information relating to the sample, its components, potentially physico-chemical properties, and improved capacity for absolute identification may be realised. Sample-to-sample comparison is improved, and sample characterisation is facilitated especially when MDGC is combined with the informing power of modern mass spectrometry. Innovative MDGC arrangements allow high resolution coupled with spectroscopy and alternative bioassays, and delivers molecular elucidation in ways that are beyond just simple analysis of volatiles.

Review of the role and methodology of high resolution approaches in aroma analysis

“…9. (left) Instrument schematic of the integrated GC Â GC/MDGC system with olfactory and mass spectral detection [90], (right) flow diagram of the strategy for odourimpact analysis in a complex sample using the integrated system [91] (reproduced with permission from the copyright holder). plot produced using GC Â GC separation, any desired co-eluted regions from the 1 D column can be selected to permit targeted MDGC separation on a longer 2 D column than that employed for GC Â GC operation.…”

Addressing the Challenges to Identification in Gas Chromatography by Increased Resolution and Enhanced Detection Modalities

“…[17] Marriott et al [18] expanded on multidimensionality that covered both the above topics of MDGC and GC GC. Recently Chin andM arriott [19] extended that review to include aspects that focused on the opportunitiesa fforded by the 2D presentation of GC GC beyond providing separation alone and also describede xperimentalm odes that covered sequential coupling of two, three, and more columns. An example of a methodt hat embodies the multiple columna pproach in a single analysisi st he so-called hybrid technique, which comprises elements of both GC GC and MDGC.…”

Characterization of the aroma profile of novel Brazilian wines by solid-phase microextraction using polymeric ionic liquid sorbent coatings

“…Today, such techniques are embodied by thermal, valve-based, and flow interfaces. Excellent reviews describing the most important developments of GC×GC are available for the interested reader [19][20][21][22][23].…”