Multidirectional chromosome painting reveals a remarkable syntenic homology between the greater galagos and the slow loris

Stanyon, Roscoe; Dumas, Francesca; Stone, Gary; Bigoni, Francesca

doi:10.1002/ajp.20229

Cited by 23 publications

(22 citation statements)

References 24 publications

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“…The orthologue to human synteny 4 in the ancestral primate karyotype, a submetacentric chromosome, is derived from the fission of the ancestral 4/8 association. In Strepsirrhini, synteny 4 was divided into two segments (Stanyon et al 2002(Stanyon et al , 2006, which in various species have been subject to translocations (Rumpler et al 2008). In Platyrrhini, the orthologous segments are conserved as a single submetacentric chromosome in Cebidae and Pithecidae (Stanyon et al 2000;Neusser et al 2001;Dumas et al 2007), but not in Atelidae.…”

Section: Sinteny 4 Evolution In Primatesmentioning

confidence: 99%

“…The different positions of the probe signal in the two lineages can be explained as the result of a large pericentromeric inversion or of the occurrence of a Figure 2. We considered the literature regarding Strepsirrhini (Müller et al 1997;Richard et al 2000;Cardone et al 2002;Stanyon et al 2002Stanyon et al , 2006Warter et al 2005;Nie et al 2006;Rumpler et al 2008), Platyrrhini (Consigliere et al 1996(Consigliere et al , 1998Richard et al 1996;Morescalchi et al 1997;Stanyon et al 2000Stanyon et al , 2001Stanyon et al , 2003Stanyon et al , 2004Neusser et al 2001;Garcia et al 2002, De Oliveira et al 2002, 2005Barros et al 2003;Serreau et al 2004;Dumas et al 2005Dumas et al , 2007Ruiz-Herrera et al 2005;Amaral et al 2008;Finotelo et al 2010), and Catarrhini Wienberg et al 1992;Bigoni, Koehler, Stanyon, Ishida, et al 1997;Bigoni, Koehler, Stanyon, Morescalchi, et al 1997;Nie et al 1998;Finelli et al 1999;Nie et al 2001;Ruiz-Herrera et al 2002;Müller et al 2003;Bigoni et al 2003Bigoni et al , 2004Stanyon et al 2005;Moulin et al 2008) in order to reconstruct the hy...…”

Section: Marker Order Along Synteny 4 In Primatesmentioning

confidence: 99%

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The evolution of human synteny 4 by mapping sub-chromosomal specific probes in Primates

Dumas

Sineo

2014

Caryologia

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Comparative cytogenetic data concerning the orthologue to human chromosome 4 in primates shows that this chromosome is conserved between humans and non-human primates. However, the degree of conservation is not as high as previously estimated. In primates it is as a rule a large submetacentric chromosome but many exceptions are known especially in taxa characterized by a high level of chromosomal rearrangements. The rearrangements that have been visualized by chromosome painting so far, which are mostly interchromosomal changes, are in fact only a fraction of the actual chromosomal changes that have occurred during evolution. Intrachromosome changes can be analysed through classical cytogenetic approach or by mapping sub-chromosomal specific probes. In order to study human synteny 4 evolution we mapped diverse subchromosomal specific probes on chromosomes of representative species of the main primate taxa, with the aim to verify markers order conservation along the orthologues to human chromosome 4, allowing us the detection of possible intra-chromosomal rearrangements. The mapping of these probes permitted us to test previous cytogenetic hypothesis on human synteny 4 evolution, and to show marker order conservation between orthologues to human synteny 4 in Catarrhini and Platyrrhini, but with a different position of the centromeres. This data permitted us to hypothesize the occurrence of a new centromere evolution in one of the two lineages. Moreover we analysed literature data regarding HSA4 homologous in primates with particular attention to Platyrrhini, allowing us the reconstruction of the changes that synteny 4 has undergone during evolution. Lastly we highlight the value of the subchromosomal specific probes mapping approach in the detection of intrachromosomal rearrangements that can be crucial for a more refined comparative mapping and for phylogenetic reconstruction.

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Section: Sinteny 4 Evolution In Primatesmentioning

confidence: 99%

Section: Marker Order Along Synteny 4 In Primatesmentioning

confidence: 99%

The evolution of human synteny 4 by mapping sub-chromosomal specific probes in Primates

Dumas

Sineo

2014

Caryologia

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“…In strepsirrhine primates, Dermoptera and Scandentia, nearly 30 species have been analyzed by chromosome painting [Apiou et al, 1996;Müller et al, 1997Müller et al, , 1999Vezuli et al, 1997;Cardone et al, 2002;Stanyon et al, 2002Stanyon et al, , 2006Warter et al, 2005;Nie et al, 2006Nie et al, , 2008Rumpler et al, 2008;Dumas et al, 2012]. Chromosome homologies between human ( Homo sapiens , HSA) and these studied species have been established in all of these studies by using partial or the whole set of human chromosome-specific probes.…”

Section: Chromosome Painting In Strepsirrhini Dermoptera and Scandentiamentioning

confidence: 99%

“…Besides human chromosome-specific probes, 7 sets of chromosome-specific probes from 2 lemurs ( Eulemur fulvus mayottensis , 2n = 60, and E . macaco macaco , 2n = 44) [Müller et al, 1997], 2 galagos ( Galago moholi , 2n = 38) [Nie et al, 2006], ( Otolemur garnettii , 2n = 62) [Stanyon et al, 2006], 1 slow loris ( Nycticebus coucang , 2n = 50) [Stanyon et al, 2006], 1 tree shrew ( Tupaia belangeri , 2n = 62) [Müller et al, 1999], and 1 flying lemur ( G. variegates , 2n = 56) [Nie et al, 2008] have been prepared from flow sorted chromosomes and used in some of these studies. In addition, locus-specific probes derived from the human BAC/PAC libraries have also been used in some of these studies to reconstruct ancestral marker order [Cardone et al, 2002;Stanyon et al, 2008 and references therein].…”

Section: Chromosome Painting In Strepsirrhini Dermoptera and Scandentiamentioning

confidence: 99%

Molecular Cytogenetic Studies in Strepsirrhine Primates, Dermoptera and Scandentia

Nie¹

2012

Cytogenet Genome Res

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Since the first chromosome painting study between human and strepsirrhine primates was performed in 1996, nearly 30 species in Strepsirrhini, Dermoptera and Scandentia have been analyzed by cross-species chromosome painting. Here, the contribution of chromosome painting data to our understanding of primate genome organization, chromosome evolution and the karyotype phylogenetic relationships within strepsirrhine primates, Dermoptera and Scandentia is reviewed. Twenty-six to 43 homologous chromosome segments have been revealed in different species with human chromosome-specific paint probes. Various landmark rearrangements characteristic for each different lineage have been identified, as cytogenetic signatures that potentially unite certain lineages within strepsirrhine primates, Dermoptera and Scandentia.

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“…In the ancestral eutherian karyotype, the synteny of chromosome 7 was divided into 2 segments: a large, probably acrocentric chromosome and a small chromosome segment associated with the short arm of human chromosome 16 (HSA 16p) [Richard et al, 2000]. Recent reciprocal painting in Lorisiformes suggests that the 7/16 association was conserved in the ancestral primate genome [Stanyon et al, 2006] and underwent fissioning in the common ancestor of Haplorhini.…”

Section: Introductionmentioning

confidence: 99%

Exploring Evolution in Ceboidea (Platyrrhini, Primates) by Williams-Beuren Probe (HSA 7q11.23) Chromosome Mapping

Picone

Dumas²,

Stanyon³

et al. 2008

IJFP

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The ancestral platyrrhine karyotype was characterised by a syntenic association of human 5 and a small segment of human 7 orthologues. This large syntenic association has undergone numerous rearrangements in various phylogenetic lines. We used a locus-specific molecular cytogenetic approach to study the chromosomal evolution of the human 7q11.23 orthologous sequences (William-Beuren syndrome, WS) in various Ceboidea (Platyrrhini) species. The fluorescent in situ hybridisation of the WS probe revealed a two-way pattern of chromosomal organisation that suggests various evolutionary scenarios. The first pattern (seen in Callimico and Saimiri) includes a fairly simple disruption of the 7/5 syntenic association by a chromosome fission. The second pattern (seen in Atelinae, Alouattinae and in Callicebus) is characterised by an increasing complexity in the 7/5 association as a consequence of a series of inversions and translocations resulting in different syntenic associations. These data support recent proposals for phylogenomic groupings of New World monkeys. The study also illustrates how single-locus probe hybridisations can reveal intrachromosomal rearrangements.

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Multidirectional chromosome painting reveals a remarkable syntenic homology between the greater galagos and the slow loris

Cited by 23 publications

References 24 publications

The evolution of human synteny 4 by mapping sub-chromosomal specific probes in Primates

The evolution of human synteny 4 by mapping sub-chromosomal specific probes in Primates

Molecular Cytogenetic Studies in Strepsirrhine Primates, Dermoptera and Scandentia

Exploring Evolution in Ceboidea (Platyrrhini, Primates) by Williams-Beuren Probe (HSA 7q11.23) Chromosome Mapping

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