Multidirectional contraction of human hypertrophied prostate

Moriyama, Nobuo; Miyata, Noriyuki; Yamaura, Hiroko; Yamazaki, Ryuzaburo; Tsuchida, Katsuharu; Kurimoto, Shigeharu; Nagase, Yasushi; Ishida, Yoshiteru; Kawabe, Kazuki

doi:10.1016/0306-3623(94)90174-0

Cited by 11 publications

(6 citation statements)

References 11 publications

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“…There may be regional differences in the binding to and functional properties of the prostatic a 1 -adrenoceptors [17], with differences in subtype populations between normal and hyperplastic prostate; the ratio of the numbers of the a 1A , a 1B , and a 1D subtype messenger RNA being 85 : 1 : 14 in BPH samples, and 63 : 6 : 31 in non-BPH samples [18]. However, no signi®cant regional differences in the contractile responses to a 1 -adrenoceptor agonists are evident [19].…”

Section: Do Alpha Adrenoceptor Antagonists Produce Apoptosis?mentioning

confidence: 63%

Alpha adrenoceptor antagonists in the year 2000: is there anything new?

Chapple

2001

Current Opinion in Urology

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Selective alpha1-adrenergic blockade is now a well accepted and widely used therapeutic treatment for patients presenting with symptomatic bladder outlet obstruction thought to be associated with benign prostatic hyperplasia. This review summarizes the recent developments in this field relating to the subject of receptor subtype selectivity and the potential relevance of this to clinical usefulness of existing drug therapy. Whilst a number of unanswered questions remain as to the exact mechanisms of both drug action and side-effect profile, nevertheless it is clear that existing clinically available alpha1-antagonists provide a safe, effective and generally well tolerated therapy for patients with lower urinary tract symptoms thought to be associated with benign prostatic obstruction. The implications of the ALLHAT study are discussed.

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Section: Do Alpha Adrenoceptor Antagonists Produce Apoptosis?mentioning

confidence: 63%

Alpha adrenoceptor antagonists in the year 2000: is there anything new?

Chapple

2001

Current Opinion in Urology

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“…However, the present study is the first to show a difference in the abundance of the α 1L subtype between the human prostate and urethra. Moriyama et al [ 24] reported that hypertrophied prostate contracts in many directions in response to α 1 ‐adrenoceptor agonists, suggesting that prostatic smooth muscle is less important in outlet obstruction than are the circular smooth muscles of the human urethra. This information, combined with the present finding of a relatively greater abundance of the α 1L subtype in the urethra, indicates that any α 1L subtype in the human prostate plays no major role in outlet obstruction, whereas the α 1L subtype in the human urethra does.…”

Section: Discussionmentioning

confidence: 99%

The α_1L‐adrenoceptor subtype in the lower urinary tract: a comparison of human urethra and prostate

Fukasawa

Taniguchi

Moriyama

et al. 1998

British Journal of Urology

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“…Prostatic tissue is mainly composed of glandular acini and stroma, the latter consisting mainly of smooth muscle cells, fibroblasts and connective tissue. Prostatic contraction is mediated by the stimulation of receptors on the surface of smooth muscle cells; α1‐adrenoceptors, which play a major role in prostatic contraction [ 11], are also known to be localized on smooth muscle cells and not on glandular cells [ 4–7]. Therefore, it is important to determine the proportion of smooth muscle area in each histological compartment of the prostate.…”

Section: Discussionmentioning

confidence: 99%

“…Its role and distribution have been evaluated by contractile studies, binding assays and autoradiography. Several autoradiographic studies have characterized the population of α1‐adrenoceptors on smooth muscle cells and their absence on glandular cells [ 3–7].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of histological structure and its effect on the distribution of α1‐adrenoceptors in human benign prostatic hyperplasia

Kurimoto

Moriyama

Hamada

et al. 1998

British Journal of Urology

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Objective To evaluate the histological structure of benign prostatic hyperplasia (BPH) and its relationship with the density of α1‐adrenoceptors in smooth muscle. Materials and methods Specimens from hyperplastic tissues obtained from 14 patients with BPH were evaluated for the density of α1‐adrenoceptors in smooth muscle using autoradiography, Mallory‐Azan staining and computer‐assisted image analyses. The binding of [3H] tamsulosin (a selective α1‐blocker) and the ratio of smooth muscle area was calculated, and the density of α1‐adrenoceptors per area of smooth muscle determined by dividing the degree of binding by the ratio of smooth muscle to total area. Results There was a significant difference between the ratio of smooth muscle area in the hyperplastic acinar nodule and the surrounding stroma (P<0.01). The density of α1‐adrenoceptor per smooth muscle area was significantly higher in the hyperplastic acinar nodule than in the surrounding stroma (P<0.05). There was no correlation between prostatic weight and the ratio of smooth muscle area or the density of α1‐adrenoceptors in each region. Conclusion The distribution of α1‐adrenoceptors on smooth muscle differed with histological structure; both the histological conformation and the difference in the distribution of α1‐adrenoceptors could affect urethral obstruction in BPH.

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Multidirectional contraction of human hypertrophied prostate

Cited by 11 publications

References 11 publications

Alpha adrenoceptor antagonists in the year 2000: is there anything new?

Alpha adrenoceptor antagonists in the year 2000: is there anything new?

The α_1L‐adrenoceptor subtype in the lower urinary tract: a comparison of human urethra and prostate

Evaluation of histological structure and its effect on the distribution of α1‐adrenoceptors in human benign prostatic hyperplasia

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Multidirectional contraction of human hypertrophied prostate

Cited by 11 publications

References 11 publications

Alpha adrenoceptor antagonists in the year 2000: is there anything new?

Alpha adrenoceptor antagonists in the year 2000: is there anything new?

The α1L‐adrenoceptor subtype in the lower urinary tract: a comparison of human urethra and prostate

Evaluation of histological structure and its effect on the distribution of α1‐adrenoceptors in human benign prostatic hyperplasia

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The α_1L‐adrenoceptor subtype in the lower urinary tract: a comparison of human urethra and prostate