Multidisciplinary Care of<scp><i>BRAF</i>-Mutant</scp>Stage<scp>III</scp>Melanoma: A Physicians Perspective Review

Cornelius, Lynn A.; Fields, Ryan C.; Tarhini, Ahmad A.

doi:10.1002/onco.13852

Cited by 6 publications

(5 citation statements)

References 55 publications

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“…At the same time, with emotional nursing, it can target depression, anxiety, and other emotions of patients, carry out submissive psychotherapy, adjust the patient's emotions, and encourage them to maintain an optimistic and positive attitude [ 17 – 20 ]. The MDT collaborative nursing joint-level nursing management model emphasizes the “patient-centered” nursing concept, details the physical and psychological aspects of nursing, and can provide patients with high-quality, professional, and comprehensive nursing services and provide social, physical, emotional, physiological, other aspects, and social support, so as to maximize the physical and psychological comfort of patients, and improve negative emotions [ 21 – 24 ].…”

Section: Discussionmentioning

confidence: 99%

The Effect of MDT Collaborative Nursing Combined with Hierarchical Nursing Management Model on the Quality of Life and Comfort of Patients with Gallbladder Stones Combined with Acute Cholecystitis after Surgery

Yang

Zheng

et al. 2022

Computational and Mathematical Methods in Medicine

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Objective. To explore the effect of MDT (multidisciplinary team) collaborative nursing combined with hierarchical nursing management mode on the quality of life and comfort of patients with gallbladder stones combined with acute cholecystitis after surgery. Methods. A total of 120 patients with gallbladder stones and acute cholecystitis who were treated in our hospital from March 2019 to March 2021 were selected as prospective research objects. According to the order of care, they were divided into control group and observation group with 60 cases each. Among them, the control group implements a hierarchical nursing management model, and the observation group implements MDT collaborative nursing based on this and compares the impact of the two groups on patient’s quality of life scores, daily self-care ability, nursing satisfaction, and comfort after nursing. Results. Before nursing, the comparison of the quality of life score, nursing comfort, and nursing ability of the two groups of patients was not statistically significant ( P > 0.05 ). After nursing, the mental vitality score, social interaction score, emotional restriction score, and mental status of the observation group were significantly higher than those of the control group. Statistics showed that the difference was statistically significant ( P < 0.05 ). After nursing, the scores of social comfort, physical comfort, and psychological comfort of the observation group were significantly higher than those of the control group, and statistics showed that the difference was statistically significant ( P < 0.05 ). The health knowledge level, self-care skills, self-care responsibility, and self-concept of the observation group after nursing were higher than those of the control group, while the score of depression and mood disorder was significantly lower than that of the control group. Statistics showed that this difference was statistically significant ( P < 0.05 ). After nursing, patients in the observation group had higher operating technique scores, service attitude scores, health education scores, psychological intervention scores, and nursing quality scores than those of the control group. Statistics showed that the difference was statistically significant ( P < 0.05 ). Conclusion. MDT collaborative nursing combined with hierarchical nursing management mode can effectively improve the self-care ability of patients with gallbladder stones complicated with acute cholecystitis, effectively improve the quality of life of patients, and improve the satisfaction and comfort of patients with nursing care. The postnursing care of patients after inflammation has a certain reference value.

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Section: Discussionmentioning

confidence: 99%

The Effect of MDT Collaborative Nursing Combined with Hierarchical Nursing Management Model on the Quality of Life and Comfort of Patients with Gallbladder Stones Combined with Acute Cholecystitis after Surgery

Yang

Zheng

et al. 2022

Computational and Mathematical Methods in Medicine

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“…The importance of the multidisciplinary team approach (MDT) in the management of the melanoma patient has been reviewed by the study by Cornelius Lynn et al; the team allows for optimization of care, improved diagnostic accuracy and timely management of side effects [ 84 ].…”

Section: Discussionmentioning

confidence: 99%

Oral Adverse Events Associated with BRAF and MEK Inhibitors in Melanoma Treatment: A Narrative Literature Review

Basilicata,

Terrano,

D'Aurelio

et al. 2024

Healthcare

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Background: Melanoma cancer represents the most lethal type of skin cancer originating from the malignant transformation of melanocyte cells. Almost 50% of melanomas show the activation of BRAF mutations. The identification and characterization of BRAF mutations led to the development of specific drugs that radically changed the therapeutic approach to melanoma. Methods: We conducted a narrative review of the literature according to a written protocol before conducting the study. This article is based on previously conducted studies. We identified articles by searching electronic databases (Medline, Google Scholar and PubMed). We used a combination of “melanoma”, “Braf-Mek inhibitors”, “ targeted therapy” and “oral side effects”. Results: Eighteen studies were reported in this article showing the relationship between the use of targeted therapy in melanoma cancer and the development of oral side effects, such as mucositis, hyperkeratosis and cellular proliferation. Conclusion: Targeted therapy plays an important role in the treatment of melanoma cancer, showing a notable increase in response rate, prolonged progression-free survival and overall survival in BRAF-mutated melanoma patients. Oral side effects represent a common finding over the course of treatment. However, these adverse effects can be easily managed in a multidisciplinary approach involving collaboration between medical oncologists and dental doctors.

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“…- Increasing referral centers for skin cancer care to promote care continuity and reduce delays ( 52 – 55 ).…”

Section: Discussionmentioning

confidence: 99%

Addressing the unmet needs of patients with BRAF-mutated melanoma in Latin America: Expert perspective

Salman¹,

Melo

Rico-Restrepo

et al. 2023

Front. Oncol.

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Melanoma represents an increasing public health burden with extensive unmet needs in Latin America (LA). A mutation in the BRAF gene is present in approximately 50% of all melanomas in White populations and is a target of precision medicine, with the potential to dramatically improve patient outcomes. Thus, increased access to BRAF testing and therapy is LA must be explored. At a multi-day conference, a panel of Latin American experts in oncology and dermatology were provided with questions to address the barriers limiting access to testing for BRAF mutation in patients with melanoma in LA, who may be eligible for targeted therapy to improve their prognosis. During the conference, responses were discussed and edited until a consensus on addressing the barriers was achieved. Identified challenges included ignorance of BRAF-status implications, limited human and infrastructural resources, affordability and reimbursement, fragmented care delivery, pitfalls in the sample journey, and lack of local data. Despite the clear benefits of targeted therapies for BRAF-mutated melanoma in other regions, there is no clear path to prepare LA for a sustainable personalized medicine approach to this disease. Due to melanoma’s time-sensitive nature, LA must aim to provide early access to BRAF testing and consider mutational status within treatment decision making. To this end, recommendations are provided and include establishing multidisciplinary teams and melanoma referral centers and improving access to diagnosis and treatment.

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Multidisciplinary Care ofBRAF-MutantStageIIIMelanoma: A Physicians Perspective Review

Cited by 6 publications

References 55 publications

The Effect of MDT Collaborative Nursing Combined with Hierarchical Nursing Management Model on the Quality of Life and Comfort of Patients with Gallbladder Stones Combined with Acute Cholecystitis after Surgery

The Effect of MDT Collaborative Nursing Combined with Hierarchical Nursing Management Model on the Quality of Life and Comfort of Patients with Gallbladder Stones Combined with Acute Cholecystitis after Surgery

Oral Adverse Events Associated with BRAF and MEK Inhibitors in Melanoma Treatment: A Narrative Literature Review

Addressing the unmet needs of patients with BRAF-mutated melanoma in Latin America: Expert perspective

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