Multidisciplinary management for esophageal and gastric cancer

Boniface, Megan; Wani, Sachin; Schefter, Tracey E.; Koo, Phillip J.; Meguid, Cheryl; Leong, Stephen; Kaplan, Jeffrey B.; Wingrove, Lisa J.; McCarter, Martin D.

doi:10.2147/cmar.s101169

Cited by 42 publications

(30 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…laryngologists, physiotherapists and social workers. 41 Treatment plans depend on clinical tumour stage, sub-site and histology of the tumour, performance status, and comorbidity. Finally, the team meeting provides an opportunity to follow-up treatment results and for recruiting patients to research studies.…”

Section: Treatment Recommendationsmentioning

confidence: 99%

Oesophageal cancer

et al. 2017

View full text Add to dashboard Cite

SummaryOesophageal cancer is a clinically challenging disease requiring a multidisciplinary approach.The extensive treatment may be associated with serious limitations in health-related quality of life and yet still a poor prognosis. Recent decades have witnessed a gradual improvement in prognosis in many countries. Endoscopic procedures have increasingly been used in the treatment of premalignant and early oesophageal tumours. Neoadjuvant therapy with chemotherapy or chemoradiotherapy has supplemented surgery as standard treatment of locally advanced oesophageal cancer. Surgery has become more standardised and centralised. There are several therapeutic alternatives for palliative treatment. This review aims to provide insights into the current clinical management, on-going controversies and future needs in oesophageal cancer.3

show abstract

Section: Treatment Recommendationsmentioning

confidence: 99%

Oesophageal cancer

et al. 2017

View full text Add to dashboard Cite

show abstract

“…As >50% of esophageal cancers are unresectable or with local invasion and organ metastasis at the time of diagnosis, only 15–25% of the patients can survive over 5 years despite of the improvements of surgery or other comprehensive treatments [ 7 ]. Therefore, investigating the mechanism underlying esophageal cancer initiation and development is critical for exploiting new diagnosis markers and therapeutic targets [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

A novel long noncoding RNA linc00460 up-regulated by CBP/P300 promotes carcinogenesis in esophageal squamous cell carcinoma

Liang

Chen

et al. 2017

Bioscience Reports

View full text Add to dashboard Cite

Esophageal cancer is one of the leading causes of cancer-related mortality because of poor prognosis. Long noncoding RNAs (lncRNAs) have been gradually demonstrated to play critical roles in cancer development. We identified a novel long noncoding RNA named linc00460 by microarray analysis using esophageal squamous cell carcinoma (ESCC) clinical samples, which has not been studied before. Our research indicated that linc00460 was overexpressed in the majority of tumor tissues and ESCC cell lines. Linc00460 expression was positively correlated with ESCC TNM stage, lymph node metastasis, and predicted poor prognosis. In vitro experiments showed that linc00460 depletion suppressed ESCC cell growth through regulating cell proliferation and cell cycle; in additional, linc00460 depletion accelerated ESCC cell apoptosis. We further revealed that linc00460 overexpression was manipulated by transcriptional co-activator CBP/P300 through histone acetylation. Given the high expression and important biological functions of linc00460, we suggest that linc00460 works as an oncogene and might be a valuable prognostic biomarker for ESCC diagnosis and treatment.

show abstract

“… 9 For example, low performance status and compromised nutritional status account for many patients’ poor quality of life and are obstacles to cancer treatment. 10 – 12 Generally age, performance status, and disease stage are widely used to risk- stratify patients with cancer and guide therapeutic strategy. 13 However, the clinical conditions of cancer patients are so complex that investigators have been prompted to search for more appropriate and less expensive biomarkers that would define a patient’s general condition for therapeutic and prognostic purposes.…”

Section: Introductionmentioning

confidence: 99%

Elevated red blood cell distribution width predicts poor prognosis in patients with oral squamous cell carcinoma

Xie

Chang

2018

CMAR

View full text Add to dashboard Cite

IntroductionAlthough red blood cell distribution width (RDW) has been reported to reflect inflammation and nutritional status and to predict prognosis in several different types of cancer, little is known about how RDW might be related to oral squamous cell carcinoma (OSCC). The present study aimed to investigate the prognostic value of preoperative RDW in OSCC patients.Materials and methodsWe included 236 OSCC patients from Jinan Stomatological Hospital (Shandong, People’s Republic of China) in this retrospective study. All enrolled patients were divided into 2 groups: high RDW (≥15%) and low RDW (<15%) according to the detected RDW values. The correlation of RDW and clinical characteristics was explored, and the prognostic significance of RDW evaluated using Kaplan–Meier curves, log-rank analysis, and the Cox proportional hazards model.ResultsThe pretreatment median RDW among all OSCC patients was 14.4%, with a range from 11.6% to 24.5%. The RDW was found to be significantly correlated with node metastasis, tumor length, and TNM stage (P<0.05 for all). As for biochemical parameters, the results showed that higher RDW values were significantly associated with hemoglobin, mean corpuscular volume, white blood cell count, albumin, and C-reactive protein (P<0.01 for all). A significant association of RDW with the tumor marker cytokeratin 19 fragments (CYFRA21-1) and squamous cell carcinoma antigen (SCC-Ag) was also observed (P=0.02, and P=0.03; respectively). Moreover, patients with higher RDW were more likely to receive postoperative therapy (P=0.02). Kaplan–Meier survival curves showed that a high RDW was significantly associated with poor overall survival (OS) (P<0.01), especially in the early stages (I–II). Multivariate analysis revealed that an elevated RDW at diagnosis was an independent prognostic factor for shorter OS (HR =1.46, 95% CI: 1.13–2.86) after adjustment for other cancer-related prognostic factors.ConclusionThese data suggest that an elevated preoperative RDW (≥15%) at diagnosis may independently predict poorer OS in patients with OSCC, but better-designed studies in the future should be performed to further confirm the value of monitoring RDW.

show abstract

Multidisciplinary management for esophageal and gastric cancer

Cited by 42 publications

References 20 publications

Oesophageal cancer

Oesophageal cancer

A novel long noncoding RNA linc00460 up-regulated by CBP/P300 promotes carcinogenesis in esophageal squamous cell carcinoma

Elevated red blood cell distribution width predicts poor prognosis in patients with oral squamous cell carcinoma

Contact Info

Product

Resources

About