Multidrug nanomedicine

Abstract

Polymer-based nanomedicines have been engineered to ratiometrically deliver three different drugs to tumors, thereby bridging in vitro-in vivo correlation and producing synergistic therapeutic efficacy in multiple myeloma mouse models.

Microfluidics-based PLGA nanoparticles of ratiometric multidrug: From encapsulation and release rates to cytotoxicity in human lens epithelial cells

“…Nanomedicines that co-encapsulate multiple drugs are increasingly recognized as useful medications for managing cancers and chronic diseases [ 1 , 2 ]. Examples of nanomedicine that have demonstrated ratiometric co-encapsulation of drug combination include liposomes, such as CPX-351, the antineoplastic liposomal drugs combination (cytarabine and daunorubicin) at the fixed ratio, polymer-based nanocarrier, micelles (e.g., Triolimus) and polymer-lipid hybrid nanoparticles [ [3] , [4] , [5] , [6] , [7] , [8] , [9] ].…”

Molecular Recognition with Macrocyclic Receptors for Application in Precision Medicine

“…The development of combination therapies represents the frontier of modern treatment because of the heterogeneity and complexity of diseases. In combination therapies, the ratio of the combined drugs is crucial, as different ratios may lead to different therapeutic efficacies (synergism or antagonism) . A nano drug delivery system is a powerful method of combining diverse drugs and unifying their pharmacokinetics.…”

“…In combination therapies, the ratio of the combined drugs is crucial, as different ratios may lead to different therapeutic efficacies (synergism or antagonism). 65 A nano drug delivery system is a powerful method of combining diverse drugs and unifying their pharmacokinetics. However, precise control and regulation of the loading and delivery ratio of drugs with repeatability remain considerable challenges.…”

A convenient protonated strategy for constructing nanodrugs from hydrophobic drug-inhibitor conjugates to reverse tumor multidrug resistance

“…5 In addition, the distinct physicochemical properties and pharmacokinetic behaviors of various small molecule drugs hinder the precise control of drug ratio reaching the tumor site by the traditional physical mixing in combination chemotherapy. 6…”