Multifunctional Amine Mesoporous Silica Spheres Modified with Multiple Amine as Carriers for Drug Release

Abstract

Mesoporous silica spheres were synthesized by using Stöber theory . Calcination of the mesostructured phase resulted in the starting solid. Organic modification with aminopropyl groups resulted in two MSN-40 materials: named MSN-NH 2 and MSN-DQ-40, respectively. These two kinds of samples with different pore sizes (obtained from 3-[2-(2-aminoethylamino)ethylamino]propyl-trimethox-ysilane (NQ-62) and modified NQ-62) showed control of the delivery rate of ibuprofen (IBU) from the siliceous matrix. The obtained sample from modified NQ-62 has an increased loading rate and shows better control of the delivery rate of IBU than the obtained sample from NQ-62. These three solids were characterized using standard solid state procedures. During tests of in vitro drug release, an interesting phenomenon was observed: at high pH (pH 7.45), IBU in all carriers was released slowly; at low pH (pH 4.5), only a part of the IBU was slowly released from this carrier within 25 hours; most IBU was effectively confined in mesoporous material, but the remaining IBU was released rapidly and completely after 25 hours.

Functionalized Large-Pore Mesoporous Silica Microparticles for Gefitinib and Doxorubicin Codelivery

“…Based on previous methods [ 29 ], we designed a facile synthetic route to produce carboxyl-functionalized large-pore mesoporous silica materials that are able to effectively encapsulate and release gefitinib and doxorubicin. To obtain the desired large pores, we employed triblock poly (ethylene glycol)-b-poly (propylene glycol)-b-(poly(ethylene glycol) (PEG-b-PPG-b-PEG) as the structure-directing template rather than the commonly used block copolymer (Pluronic P123 and F127).…”

Tris (2-aminoethyl) Amine Functionalized Nanoporous Silica SBA-15 as a Potential Drug Carrier for Citalopram

“…The release profiles at the three different pH values of 5, 7, and 8 (Figure 5) showed a faster release rate at pH=5 (lower pH), suggesting a weaker interaction because of the protonation of the amino group of the functionalized SBA-15. Li et al 39 reported similar results. They demonstrated the feasibility of controlling the delivery rate of ibuprofen occluded in two multifunctional amine mesoporous silica spheres.…”

Ultradeep Removal of Acetaldehyde from Ethanol through Catalytic Hydrogenation with Highly Dispersed Ag Nanoparticles Supported on Phenyl-Modified SiO2

“…The introduction of phenyl groups was studied by FT-IR characterization, and the results are shown in Figure . Typical bands related to the formation of a condensed siloxane network for SiO 2 materials were detected for all of the materials (1082, 798, and 469 cm –1 ). − The presence of −Ph (Figure c) led to the emergence of the absorption peaks at 739 and 696 cm –1 , which can be attributed to the C–H bending vibration peak of the benzene ring. At the same time, the appearance of Si–C, CC, and C–H (1143, 1427, and 3059 cm –1 , respectively) characteristic absorption peaks further proved the successful introduction of phenyl in the material of Ag/Ph-SiO 2 .…”