Multifunctional ferritin nanocages for bimodal imaging and targeted delivery of doxorubicin into cancer cells

Abstract

Schematic illustration of design of Fe3O4–AFn/DOX–Cdots composite.

Passive Diffusion vs Active pH-Dependent Encapsulation of Tyrosine Kinase Inhibitors Vandetanib and Lenvatinib into Folate-Targeted Ferritin Delivery System

“…For the purpose of TKIs-loading, commercially purified E. caballus spleen L-subunit-rich FRTs were utilized, with excelling biocompatibility, biodegradability, non-toxicity and high loading efficiency as has been previously demonstrated for a variety of bioactive compounds. 15,17,20,21,[32][33][34] N-PAGE revealed that the FRTs were single protein complex with an apparent MW of about 480 kDa (Figure 2A). Upon pH-dependent reassembly w/o payload, FRTs successfully retained their structural integrity and charge, which is in line with Stuhn et al 35 Similar findings were further obtained for both types of TKIs loading.…”