Multifunctional homogeneous calcium phosphate coatings: Toward antibacterial and cell adhesive titanium scaffolds

Abstract

ARTICLE INFO Titaniwn scaffolds Calciwn phosphate coating Chlorhexidine dig)uconate Antibacterial Biocompatibility On-ep pulse electrodeposition

Bioceramic-based scaffolds with antibacterial function for bone tissue engineering: A review

“…As a common antibacterial agent, chlorhexidine has a broad-spectrum bactericidal effect and low drug resistance. Loading chlorhexidine into bioceramic-based composite scaffolds gave the scaffolds strong antibacterial properties, indicating the potential for biomedical applications, particularly controlled drug delivery in dentistry [ 53 , 54 ]. Berberine, an alkaloid component extracted from botanicals, has been long used as a heat-clearing, detoxifying and antibacterial drug.…”

Structural and Material Determinants Influencing the Behavior of Porous Ti and Its Alloys Made by Additive Manufacturing Techniques for Biomedical Applications

“…The apatite-forming ability test and in vitro cell culture assay resulted in the highest apatite formation and significantly greater adhesion and differentiation of mesenchymal stem cells (MSCs) on the HT/AH-porous Ti6Al4V compared to the scaffolds without HAp-coating [200]. In [217], the pulsed reverse electrodeposition was used to obtain calcium phosphate (CaP) coatings doped with chlorhexidine digluconate on an additively manufactured CP-Ti scaffold. The result showed the surface of scaffolds was covered by plate-like and whisker-like calcium phosphate crystals with a Ca/P ratio of 1.30.…”

“…After the 7th day of in vitro assay, the cells cultured on the 3D-Ti-NTs-MBG scaffolds presented no significantly different proliferation rates, when compared with those on the 3D-Ti-NTs scaffolds. In [217], cell behavior on CP-Ti scaffold coated by calcium phosphate (CaP) showed that the addition of CHX decreased cell adhesion in comparison to the scaffolds with CaP coatings.…”

“…However, in vivo implantation in the rat tibia indicated that all implants were colonized with bacteria after 28 days, among them the Ch+Vanco group significantly reduced bone infection as compared to other implants (Ch-only, Ch+Ag) [245]. In [217] multifunctional CaP coating loaded with chlorhexidine digluconate (CHX) at 0.75, 1.5, and 3 mM was successfully applied on DIW-manufactured CP-Ti scaffolds to reduce bacterial adhesion. The biological tests showed that the as-coated scaffolds reduced bacteria adhesion by 73% for Staphylococcus aureus and 70% for Escherichia coli.…”

Sustainable Coatings on Metallic Alloys as a Nowadays Challenge

“…Titanium and titanium alloys are also intensively used in a large number of applications, due to their outstanding corrosion resistance, great mechanical properties, and good biocompatibility [54,96]. A problem with these alloys as biomaterials is that they may be a cause of thrombosis when they come into contact with blood, as in the case of coronary stents, and anticoagulation medication is usually prescribed to prevent this from happening.…”