Multifunctional layered black phosphorene-based nanoplatform for disease diagnosis and treatment: a review

Huang, Xianghua; Zhou, Yingying; Woo, Chi Man; Pan, Yue; Nie, Liming; Lai, Puxiang

doi:10.1007/s12200-020-1084-1

Cited by 13 publications

(5 citation statements)

References 125 publications

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“…197,218,219 New technologies such as microfluidics, photoetching, and 3D printing can help to obtain adhesive hydrogels with finer micro-nano structures. 112,119,[220][221][222] We are confident to see that bio-inspired adhesive hydrogels are not just blunt imitations of natural strategies, but combine the unique advantages of various advanced materials and technologies. It is believed that with the development of materials science and other fields, biomedical hydrogels that perfectly meet the requirements of safety, robustness, appropriateness, and controllability will be developed.…”

Section: Discussionmentioning

confidence: 99%

“…Besides temperature control, more control strategies for the adhesion behavior of hydrogels have also been applied, such as magnetic field, electric field, light field, ultrasonic wave, etc 197,218,219 . New technologies such as microfluidics, photoetching, and 3D printing can help to obtain adhesive hydrogels with finer micro–nano structures 112,119,220–222 . We are confident to see that bio‐inspired adhesive hydrogels are not just blunt imitations of natural strategies, but combine the unique advantages of various advanced materials and technologies.…”

Section: Discussionmentioning

confidence: 99%

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Bio‐inspired adhesive hydrogel for biomedicine—principles and design strategies

Yang

Lai

et al. 2022

Smart Medicine

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The adhesiveness of hydrogels is urgently required in various biomedical applications such as medical patches, tissue sealants, and flexible electronic devices. However, biological tissues are often wet, soft, movable, and easily damaged. These features pose difficulties for the construction of adhesive hydrogels for medical use. In nature, organisms adhere to unique strategies, such as reversible sucker adhesion in octopuses and nontoxic and firm catechol chemistry in mussels, which provide many inspirations for medical hydrogels to overcome the above challenges. In this review, we systematically classify bioadhesion strategies into structure‐related and molecular‐related ones, which cover almost all known bioadhesion paradigms. We outline the principles of these strategies and summarize the corresponding designs of medical adhesive hydrogels inspired by them. Finally, conclusions and perspectives concerning the development of this field are provided. For the booming bio‐inspired adhesive hydrogels, this review aims to summarize and analyze the various existing theories and provide systematic guidance for future research from an innovative perspective.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Bio‐inspired adhesive hydrogel for biomedicine—principles and design strategies

Yang

Lai

et al. 2022

Smart Medicine

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“…BP has been developed as saturable absorbers for solid-state lasers to create short pulses because to its high potential for pulse generation in the 3 μm spectral region of the mid-infrared [ 25 ]. The excellent biocompatibility and biodegradability of BP in vivo imply that it is more likely than other materials to be acceptable for interdisciplinary biological applications [ 8 , 26 , 27 ]. Due to edge states and quantum confinement phenomena, BP nanoribbons and zero-dimensional quantum dots with unique properties can be produced by morphological engineering.…”

Section: Synthesis and Properties Of Black Phosphorusmentioning

confidence: 99%

Research progress on black phosphorus hybrids hydrogel platforms for biomedical applications

Zhao

Jiang

et al. 2023

J Biol Eng

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Hydrogels, also known as three-dimensional, flexible, and polymer networks, are composed of natural and/or synthetic polymers with exceptional properties such as hydrophilicity, biocompatibility, biofunctionality, and elasticity. Researchers in biomedicine, biosensing, pharmaceuticals, energy and environment, agriculture, and cosmetics are interested in hydrogels. Hydrogels have limited adaptability for complicated biological information transfer in biomedical applications due to their lack of electrical conductivity and low mechanical strength, despite significant advances in the development and use of hydrogels. The nano-filler-hydrogel hybrid system based on supramolecular interaction between host and guest has emerged as one of the potential solutions to the aforementioned issues. Black phosphorus, as one of the representatives of novel two-dimensional materials, has gained a great deal of interest in recent years owing to its exceptional physical and chemical properties, among other nanoscale fillers. However, a few numbers of publications have elaborated on the scientific development of black phosphorus hybrid hydrogels extensively. In this review, this review thus summarized the benefits of black phosphorus hybrid hydrogels and highlighted the most recent biological uses of black phosphorus hybrid hydrogels. Finally, the difficulties and future possibilities of the development of black phosphorus hybrid hydrogels are reviewed in an effort to serve as a guide for the application and manufacture of black phosphorus -based hydrogels. Graphical Abstract Recent applications of black phosphorus hybrid hydrogels in biomedicine.

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“…More importantly, many endogenous tissue constituents, such as oxyhemoglobin, deoxyhemoglobin, and water, possess distinctive optical absorption spectra and hence can be used as natural contrasts to be captured under optical illumination of different wavelengths to indicate status of targets, providing label-free functional and molecular specific information [12]. In scenarios where the endogenous contrasts cannot yield sufficient signal-to-noise ratio (SNR), for example to detect cancer from blood rich organs like liver, exogenous contrast agents can be added and accumulate at the region of interest, which leads to increased contrast and highlighted object imaging [13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Light on osteoarthritic joint: from bench to bed

Zhou¹,

Ni²,

Wen³

et al. 2022

Theranostics

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Osteoarthritis (OA) is one of the rapidly growing disability-associated conditions with population aging worldwide. There is a pressing need for precise diagnosis and timely intervention for OA in the early stage. Current clinical imaging modalities, including pain radiography, magnetic resonance imaging, ultrasound, and optical coherent tomography, are limited to provide structural changes when the damage has been established or advanced. It prompts further endeavors in search of novel functional and molecular imaging, which potentially enables early diagnosis and intervention of OA. A hybrid imaging modality based on photothermal effects, photoacoustic imaging, has drawn wide attention in recent years and has seen a variety of biomedical applications, due to its great performance in yielding high-contrast and high-resolution images from structure to function, from tissue down to molecular levels, from animals to human subjects. Photoacoustic imaging has witnessed gratifying potentials and preliminary effects in OA diagnosis. Regarding the treatment of OA, photothermal-triggered therapy has exhibited its attractions for enhanced therapeutic outcomes. In this narrative review, we will discuss photoacoustic imaging for the diagnosis and monitoring of OA at different stages. Structural, functional, and molecular parameter changes associated with OA joints captured by photoacoustics will be summarized, forming the diagnosis perspective of the review. Photothermal therapy applications related to OA will also be discussed herein. Lastly, relevant clinical applications and its potential solutions to extend photoacoustic imaging to deeper OA situations have been proposed. Although some aspects may not be covered, this mini review provides a better understanding of the diagnosis and treatment of OA with exciting innovations based on tissue photothermal effects. It may also inspire more explorations in the field towards earlier and better theranostics of OA.

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Multifunctional layered black phosphorene-based nanoplatform for disease diagnosis and treatment: a review

Cited by 13 publications

References 125 publications

Bio‐inspired adhesive hydrogel for biomedicine—principles and design strategies

Bio‐inspired adhesive hydrogel for biomedicine—principles and design strategies

Research progress on black phosphorus hybrids hydrogel platforms for biomedical applications

Light on osteoarthritic joint: from bench to bed

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