Multifunctional nanomicellar systems for delivering anticancer drugs

Chen, Yi-Chun; Lo, Chun Liang; Hsiue, Ging Ho

doi:10.1002/jbm.a.34850

Cited by 34 publications

(27 citation statements)

References 132 publications

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“…The biocompatibility and biodegradability of PEG has been demonstrated in a number of studies [30,31]. Moreover, the short-and long-term influence of PEGylation on biodegradability of MSNs in different media including aqueous solutions [32], simulated body fluids (SBF) [33], phosphate buffered saline (PBS) [34], and Dulbecco's modified eagle's medium (DMEM) with fetal bovine serum (FBS) [32] has been evaluated.…”

Section: Discussionmentioning

confidence: 99%

Low-melting-point polymeric nanoshells for thermal-triggered drug release under hyperthermia condition

Dabbagh

Mahmoodian

Abdullah

et al. 2015

International Journal of Hyperthermia

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Purpose: The aim of this paper was to synthesise core-shell nanostructures comprised of mesoporous silica core and a low melting-point polyethylene glycol (PEG) nanoshell with a sharp gel-liquid phase transition for rapid drug release at hyperthermia temperature range. Materials and methods:The phase transition behaviours of PEGs with molecular weights of 1000, 1500, and 2000 Da were analysed using differential scanning calorimetry (DSC) to determine the optimal formulation with phase transition in the hyperthermia range. The 'graftto' method was employed to synthesise core-shell nanostructures using the selected PEG formulation. The drug loading and release behaviours of these nanocarriers were examined by ultra-violet visible spectroscopy (UV-Vis) using doxorubicin as a model drug. Magnetic resonance-guided focused ultrasound (MRgFUS) was also applied as a typical thermal modality to evaluate the rate of drug release from the core-shell nanostructures. Results: The PEG molecular weight of 1500 Da presented the optimal phase transition temperature for thermaltriggered release under hyperthermia conditions. Drug release measurements at different temperatures using UV-Vis methods showed a 20.2 ± 4.3% leakage in aqueous solution at 37 C after 30 min, while this value was significantly increased to 68.2 ± 3.7% at 50 C. A 45.5 ± 3.1% drug release was also obtained after sonication of the drug-loaded nanoparticles for 5 Â 20 s using MRgFUS. Conclusion: Although the ratio of drug leakage at physiological temperatures was relatively high, the sharp transition temperature, high loading efficiency, and fast drug release at hyperthermia temperature range could make these core-shell nanoparticles prominent for enhancing the efficacy of various hyperthermia modalities in the treatment of cancer tumours.

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Section: Discussionmentioning

confidence: 99%

Low-melting-point polymeric nanoshells for thermal-triggered drug release under hyperthermia condition

Dabbagh

Mahmoodian

Abdullah

et al. 2015

International Journal of Hyperthermia

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“…Compared with other nanoparticles, the attractive features of polymeric micelles include high stability, high drug solubility, and prevention of the interactions between payloads and serum components in trafficking [8]. To achieve the tumor-selective drug release and reduce the normal cells damages, environmentally sensitive polymer micelles have been proposed and fabricated in response to the biological differences between malignant cells and normal cells [9].…”

Section: Introductionmentioning

confidence: 99%

Reactive oxygen species and glutathione dual redox-responsive micelles for selective cytotoxicity of cancer

Chiang¹,

Yen²,

Lo³

2015

Biomaterials

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135

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“…In addition, different delivery systems can also be employed in the encapsulation of probes, such as micelles, nanoparticles, and polymers. 8 …”

Section: Introductionmentioning

confidence: 99%

RGD-conjugated two-photon absorbing near-IR emitting fluorescent probes for tumor vasculature imaging

et al. 2015

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Observation of the activation and inhibition of angiogenesis processes is important in the progression of cancer. Application of targeting peptides, such as a small peptide that contains adjacent L-arginine (R), glycine (G) and L-aspartic acid (D) residues can afford high selectivity and deep penetration in vessel imaging. To facilitate deep tissue vasculature imaging, probes that can be excited via two-photon absorption (2PA) in the near-infrared (NIR) and subsequently emit in the NIR are essential. In this study, the enhancement of tissue image quality with RGD conjugates was investigated with new NIR-emitting pyranyl fluorophore derivatives in two-photon fluorescence microscopy. Linear and nonlinear photophysical properties of the new probes were comprehensively characterized; significantly the probes exhibited good 2PA over a broad spectral range from 700–1100 nm. Cell and tissue images were then acquired and examined, revealing deep penetration and high contrast with the new pyranyl RGD-conjugates up to 350 μm in tumor tissue.

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Multifunctional nanomicellar systems for delivering anticancer drugs

Cited by 34 publications

References 132 publications

Low-melting-point polymeric nanoshells for thermal-triggered drug release under hyperthermia condition

Low-melting-point polymeric nanoshells for thermal-triggered drug release under hyperthermia condition

Reactive oxygen species and glutathione dual redox-responsive micelles for selective cytotoxicity of cancer

RGD-conjugated two-photon absorbing near-IR emitting fluorescent probes for tumor vasculature imaging

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