Multifunctional nanomicelles constructed<i>via</i>an aggregation and de-aggregation strategy for magnetic resonance/NIR II fluorescence imaging-guided type I photodynamic therapy

Wang, Lirong; Qi, Ji; Zhang, Ke; Zhuang, Zeyan; Ding, Keke; Chen, Xu; Shan, Hong; Qin, Anjun; Tang, Benzhong

doi:10.1039/d3qm00347g

Mater. Chem. Front.

2023

DOI: 10.1039/d3qm00347g

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Multifunctional nanomicelles constructedviaan aggregation and de-aggregation strategy for magnetic resonance/NIR II fluorescence imaging-guided type I photodynamic therapy

Lirong Wang

Ji Qi

Ke Zhang

et al.

Abstract: Fluorescence and magnetic resonance imaging (FL/MRI) has received much attention from their complementary characteristics. However, the simultaneous enhancement of fluorescence and MR signals plus the efficacy of the treatment is...

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Cited by 5 publications

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Near‐infrared aggregation‐induced emission materials: Bibliometric analysis and their application in biomedical field

He,

Wang,

Zhao

et al. 2024

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Aggregation‐induced emission (AIE) is an intriguing photophysical phenomenon, where specific materials exhibit a remarkable surge in luminescence when brought together in non‐ideal solvents or within a solid matrix. Since the concept of AIE was first introduced in 2001, numerous advanced applications have been gradually explored across various domains, including optics, electronics, energy, and the life sciences. Of particular note is the growing interest in the application of AIE systems with near‐infrared (NIR) emissive feature in the field of biomedicine, encompassing detection, imaging, and therapeutic interventions. Notably, bibliometric analysis serves as a valuable tool to provide researchers with a comprehensive understanding of research achievements and developmental trends in specific fields, which is crucial for academic research. Herein, we present a general bibliometric overview spanning two decades of NIR‐AIE development. With the assistance of core scientific databases and various bibliometric software tools, we conducted a systematic analysis of annual publications and citations, the most influential countries/regions, leading authors, journals, and institutions, as well as the hot topics related to NIR applications and forward‐looking predictions. Furthermore, the application of AIE with NIR properties in the biomedical field is also systematically reviewed.

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Near‐infrared aggregation‐induced emission materials: Bibliometric analysis and their application in biomedical field

He,

Wang,

Zhao

et al. 2024

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Sonodynamic Therapy‐Driven Immunotherapy: Constructing AIE Organic Sonosensitizers Using an Advanced Receptor‐Regulated Strategy

Tian,

Li,

et al. 2024

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Benefit from the deeper penetration of mechanical wave, ultrasound (US)‐based sonodynamic therapy (SDT) executes gratifying efficacy in treating deep‐seated tumors. Nevertheless, the complicated mechanism of SDT undeniably hinders the exploration of ingenious sonosensitizers. Herein, a receptor engineering strategy of aggregation‐induced emission (AIE) sonosensitizers (TPA‐Tpy) with acceptor (A)‐donor (D)‐A’ structure is proposed, which inspects the effect of increased cationizations on US sensitivity. Under US stimulation, enhanced cationization in TPA‐Tpy improves intramolecular charge transfer (ICT) and accelerates charge separation, which possesses a non‐negligible promotion in type I reactive oxygen species (ROS) production. Moreover, abundant ROS‐mediated mitochondrial oxidative stress triggers satisfactory immunogenic cell death (ICD), which further promotes the combination of SDT and ICD. Subsequently, subacid pH‐activated nanoparticles (TPA‐Tpy NPs) are constructed with charge‐converting layer (2,3‐dimethylmaleic anhydride‐poly (allylamine hydrochloride)‐polyethylene glycol (DMMA‐PAH‐PEG)) and TPA‐Tpy, achieving the controllable release of sonosensitizers. In vivo, TPA‐Tpy‐mediated SDT effectively initiates the surface‐exposed of calreticulin (ecto‐CRT), dendritic cells (DCs) maturation, and CD8+ T cell infiltration rate through enhanced ROS production, achieving suppression and ablation of primary and metastatic tumors. This study provides new opinions in regulating acceptors with eminent US sensitization, and brings a novel ICD sono‐inducer based on SDT to realize superior antitumor effect.

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Recent advances in fluorescence imaging-guided photothermal therapy and photodynamic therapy for cancer: From near-infrared-I to near-infrared-II

Luo,

Gao

2023

Journal of Controlled Release

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Multifunctional nanomicelles constructedviaan aggregation and de-aggregation strategy for magnetic resonance/NIR II fluorescence imaging-guided type I photodynamic therapy

Abstract: Fluorescence and magnetic resonance imaging (FL/MRI) has received much attention from their complementary characteristics. However, the simultaneous enhancement of fluorescence and MR signals plus the efficacy of the treatment is...

Cited by 5 publications

References 39 publications

Near‐infrared aggregation‐induced emission materials: Bibliometric analysis and their application in biomedical field

Near‐infrared aggregation‐induced emission materials: Bibliometric analysis and their application in biomedical field

Sonodynamic Therapy‐Driven Immunotherapy: Constructing AIE Organic Sonosensitizers Using an Advanced Receptor‐Regulated Strategy

Recent advances in fluorescence imaging-guided photothermal therapy and photodynamic therapy for cancer: From near-infrared-I to near-infrared-II

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