Multifunctional Platforms Based on Graphene Oxide and Natural Products

Croitoru, Alexa-Maria; Oprea, Ovidiu; Nicoara, Adrian Ionut; Trușcă, Roxana; Radu, Mihai; Neacșu, Ionela Andreea; Ficai, Denisa; Ficai, Anton; Andronescu, Ecaterina

doi:10.3390/medicina55060230

Cited by 26 publications

(21 citation statements)

References 83 publications

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“…Figure 4 presents the structure of GO at 1000 × magnification as very thin agglomerated nanosheets. The waved and folded shape of GO is presented at 50 k× magnification, the results being similar to those found in previous studies [28,29,40,41]. The specific sheets of GO are not planar because GO has a high degree of functionalization.…”

Section: Scanning Electron Microscopysupporting

confidence: 86%

“…To synthesize GO, a modified Hummers method was used; the steps are presented in Scheme 1 [28,29]. Graphite powder (20 g) was blended with a mixed solution containing 60 mL H 2 SO 4 , 10 g P 2 O 5 and 10 g K 2 S 2 O 8 heated in advance to 80 • C. The solution was filtered after cooling and rewashed until the filtrate had no residual acid.…”

Section: Fabrication Of Gomentioning

confidence: 99%

“…Materials 2020, 13, x FOR PEER REVIEW 3 of 13 mixture was rewashed with 5% HCl and deionized water until the pH became neutral. The resulting product was dried in an oven for 24 h at 60 °C, and GO was obtained [29]. Scheme 1.…”

Section: Fabrication Of Gomentioning

confidence: 99%

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Chitosan/Graphene Oxide Nanocomposite Membranes as Adsorbents with Applications in Water Purification

Croitoru

Ficai

et al. 2020

Materials

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The scope of this article is to develop composite membranes using chitosan (CS) and graphene oxide (GO) as adsorbents for the removal of inorganic pollutants such as heavy metal ions, particularly Pb2+, from aqueous solutions. GO was obtained by modified Hummers method and blended with CS solution. The introduction of ethylenediaminetetraacetic acid (EDTA) compound to CS/GO suspension lead to an increased adsorption capacity of CS/GO for the elimination of heavy metals by forming stable chelates with them. The synthesized membranes were examined by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM), and the adsorption behaviour of Pb2+ from aqueous solutions using CS/EDTA/GO membranes was evaluated using inductively coupled plasma mass spectrometry (ICP-MS). The adsorption performance of Pb2+ ions was studied by monitoring the concentration of Pb2+ against the adsorption period at an initial content of the adsorbent. The maximum adsorption efficiency of Pb2+ metal ions reached 767 mg·g−1 for CS/EDTA/GO 0.1%, 889 mg·g−1 for CS/EDTA/GO 0.3%, 970 mg·g−1 for CS/EDTA, 853 mg·g−1 for CS and 1526 mg·g−1 for GO. These findings show promising potential for CS/EDTA/GO membranes as effective adsorbent materials for the removal of heavy metal ions in water.

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Section: Scanning Electron Microscopysupporting

confidence: 86%

Section: Fabrication Of Gomentioning

confidence: 99%

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Chitosan/Graphene Oxide Nanocomposite Membranes as Adsorbents with Applications in Water Purification

Croitoru

Ficai

et al. 2020

Materials

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“…D-isomer of 3.5 wt.%, and has a molecular weight around 120.000 g/mol. GO powder was obtained by Hummers’ modified method [ 26 ] (~4.2 nm in thickness, ~10–20 layers) and Q (CAS: 6151-25-3) was purchased from Sigma-Aldrich, Taufkirchen, Germany. Dichloromethane (DCM) (CAS: 75-09-2) was purchased from ISOLAB, Wertheim, Germany.…”

Section: Methodsmentioning

confidence: 99%

Electrically Triggered Drug Delivery from Novel Electrospun Poly(Lactic Acid)/Graphene Oxide/Quercetin Fibrous Scaffolds for Wound Dressing Applications

et al. 2021

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The novel controlled and localized delivery of drug molecules to target tissues using an external electric stimulus makes electro-responsive drug delivery systems both feasible and desirable, as well as entailing a reduction in the side effects. Novel micro-scaffold matrices were designed based on poly(lactic acid) (PLA) and graphene oxide (GO) via electrospinning. Quercetin (Q), a natural flavonoid, was loaded into the fiber matrices in order to investigate the potential as a model drug for wound dressing applications. The physico-chemical properties, electrical triggering capacity, antimicrobial assay and biocompatibility were also investigated. The newly fabricated PLA/GO/Q scaffolds showed uniform and smooth surface morphologies, without any beads, and with diameters ranging from 1107 nm (10%PLA/0.1GO/Q) to 1243 nm (10%PLA). The in vitro release tests of Q from the scaffolds showed that Q can be released much faster (up to 8640 times) when an appropriate electric field is applied compared to traditional drug-release approaches. For instance, 10 s of electric stimulation is enough to ensure the full delivery of the loaded Q from the 10%PLA/1%GO/Q microfiber scaffold at both 10 Hz and at 50 Hz. The antimicrobial tests showed the inhibition of bacterial film growth. Certainly, these materials could be loaded with more potent agents for anti-cancer, anti-infection, and anti-osteoporotic therapies. The L929 fibroblast cells cultured on these scaffolds were distributed homogeneously on the scaffolds, and the highest viability value of 82.3% was obtained for the 10%PLA/0.5%GO/Q microfiber scaffold. Moreover, the addition of Q in the PLA/GO matrix stimulated the production of IL-6 at 24 h, which could be linked to an acute inflammatory response in the exposed fibroblast cells, as a potential effect of wound healing. As a general conclusion, these results demonstrate the possibility of developing graphene oxide-based supports for the electrically triggered delivery of biological active agents, with the delivery rate being externally controlled in order to ensure personalized release.

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“…Otherwise, some researchers employed the anticancer ability of this antioxidant. In this regard, Croitoru et al [ 178 ] designed a multifunctional platform based on GO, synthesized by the traditional Hummers´ method, that acted as a nanocarrier where biologically active substances, such as GA could be loaded. Experimental results showed about 70% release in less than one day, 75% in four days, and 80% within 10 days.…”

Section: Graphene-based Sensors For Bioactive Compoundsmentioning

confidence: 99%

Graphene-Based Sensors for the Detection of Bioactive Compounds: A Review

Sainz-Urruela

Vera

Andrés

et al. 2021

IJMS

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Over the last years, different nanomaterials have been investigated to design highly selective and sensitive sensors, reaching nano/picomolar concentrations of biomolecules, which is crucial for medical sciences and the healthcare industry in order to assess physiological and metabolic parameters. The discovery of graphene (G) has unexpectedly impulsed research on developing cost-effective electrode materials owed to its unique physical and chemical properties, including high specific surface area, elevated carrier mobility, exceptional electrical and thermal conductivity, strong stiffness and strength combined with flexibility and optical transparency. G and its derivatives, including graphene oxide (GO) and reduced graphene oxide (rGO), are becoming an important class of nanomaterials in the area of optical and electrochemical sensors. The presence of oxygenated functional groups makes GO nanosheets amphiphilic, facilitating chemical functionalization. G-based nanomaterials can be easily combined with different types of inorganic nanoparticles, including metals and metal oxides, quantum dots, organic polymers, and biomolecules, to yield a wide range of nanocomposites with enhanced sensitivity for sensor applications. This review provides an overview of recent research on G-based nanocomposites for the detection of bioactive compounds, providing insights on the unique advantages offered by G and its derivatives. Their synthesis process, functionalization routes, and main properties are summarized, and the main challenges are also discussed. The antioxidants selected for this review are melatonin, gallic acid, tannic acid, resveratrol, oleuropein, hydroxytyrosol, tocopherol, ascorbic acid, and curcumin. They were chosen owed to their beneficial properties for human health, including antibiotic, antiviral, cardiovascular protector, anticancer, anti-inflammatory, cytoprotective, neuroprotective, antiageing, antidegenerative, and antiallergic capacity. The sensitivity and selectivity of G-based electrochemical and fluorescent sensors are also examined. Finally, the future outlook for the development of G-based sensors for this type of biocompounds is outlined.

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Multifunctional Platforms Based on Graphene Oxide and Natural Products

Cited by 26 publications

References 83 publications

Chitosan/Graphene Oxide Nanocomposite Membranes as Adsorbents with Applications in Water Purification

Chitosan/Graphene Oxide Nanocomposite Membranes as Adsorbents with Applications in Water Purification

Electrically Triggered Drug Delivery from Novel Electrospun Poly(Lactic Acid)/Graphene Oxide/Quercetin Fibrous Scaffolds for Wound Dressing Applications

Graphene-Based Sensors for the Detection of Bioactive Compounds: A Review

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