Multifunctional superparamagnetic iron oxide nanoparticles: Promising tools in cancer theranostics

Santhosh, Poornima Budime; Ulrih, Nataša Poklar

doi:10.1016/j.canlet.2013.04.032

Cited by 210 publications

(122 citation statements)

References 74 publications

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“…In recent years, magnetic drug targeting has been one of the most active fields in cancer therapy. Magnetic targeted drug delivery systems and magnetic nanoparticles are widely studied, [5][6][7][8][9][10] but most research has addressed the synthesis of magnetic nanoparticles by pure chemical or physical methods. The application of these magnetic nanoparticles has been hampered by various problems, such as dispersion difficulties, poor control of shape or size, and low drug-loading capability.…”

Section: Introductionmentioning

confidence: 99%

Preparation and in vitro antitumor effects of cytosine arabinoside-loaded genipin-poly-L-glutamic acid-modified bacterial magnetosomes

Liu¹,

Dai²,

Wang³

et al. 2015

IJN

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To solve the problem of synthesized magnetic nanoparticles in cancer therapy, a new drug delivery system synthesized from bacteria was used to load cytosine arabinoside (Ara-C). Genipin (GP) and poly- l -glutamic acid (PLGA) were selected as dual cross-linkers. The preparation and characterization of Ara-C-loaded GP-PLGA-modified bacterial magnetosomes (BMs) (ABMs-P), as well as their in vitro antitumor effects, were all investigated. Transmission electron micrographs (TEM) and Fourier transform infrared (FTIR) spectroscopy suggested that Ara-C could be bound to the membrane of BMs modified by GP-PLGA. The diameters of the BMs and ABMs-P were 42.0±8.6 nm and 74.9±8.2 nm, respectively. The zeta potential revealed that the nanoparticles were stable. Moreover, this system exhibited optimal drug-loading properties and long-term release behavior. The optimal encapsulation efficiency and drug-loading were 64.1%±6.6% and 38.9%±2.4%, respectively, and ABMs-P could effectively release 90% Ara-C within 40 days, without the release of an initial burst. In addition, in vitro antitumor experiments elucidated that ABMs-P is cytotoxic to HL-60 cell lines, with an inhibition rate of 95%. The method of coupling drugs on BMs using dual cross-linkers is effective, and our results reveal that this new system has potential applications for drug delivery in the future.

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Section: Introductionmentioning

confidence: 99%

Preparation and in vitro antitumor effects of cytosine arabinoside-loaded genipin-poly-L-glutamic acid-modified bacterial magnetosomes

Liu¹,

Dai²,

Wang³

et al. 2015

IJN

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“…Contrast agents are capable of changing the response of nearby atoms to modify the relaxation rates at T 1 or T 2 through localized interactions with protons of water molecules that leads to produce distinct signals which can more effectively discriminate and illuminate the tissues. [735] In actual practice, due to the small intrinsic differences, better delineation of tissues can be achieved by using exogenous contrast media. Gd-chelates consisted of high-spin paramagnetic Gd 3+ ions, were the first generation of these contrast agents.…”

Section: Mrimentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

203

171

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In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.

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“…Academic interest in magnetite (Fe 3 O 4 ) nanoparticles (iron oxide nanoparticles, IONPs) has grown steadily in recent decades [1][2][3][4][5][6][7][8][9], not only because of their unique magnetic properties, but also because their low toxicity and overall biocompatibility make them promising materials for various biomedical applications. The proposed uses include targeted drug-delivery, hyperthermic therapy, magnetic resonance imaging, immunoassays, and for biochemical separation science [10][11][12][13][14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Importance of the Inter-Electrode Distance for the Electrochemical Synthesis of Magnetite Nanoparticles: Synthesis, Characterization, Computational Modelling, and Cytotoxicity

Taimoory

Trant

Rahdar

et al. 2017

e-J. Surf. Sci. Nanotech.

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Magnetite (Fe3O4) nanoparticles, are promising inorganic nanomaterials for future biomedical applications due to their low toxicity and unique magnetic properties. However, the synthesis of these particles can often be expensive, energy intensive, and non-scalable, requiring the addition of surfactants to stabilize the material to control the particle size and avoid agglomeration. We wish to report a simple, green, surfactant-free electrochemical synthesis of these materials using a closed aqueous system at ambient temperature. Particle diameter, between 19 and 33 nm, was controlled by simply modifying the distance between the electrodes. These magnetite nanoparticles were then fully characterized using both spectroscopy and microscopy. Vibrational magnetometry indicates that as the size of the particle decreases, the magnetic hysteretic gap decreases, although for samples below 25 nm no inter-sample difference was observed. To support this experimental data, we carried out a Density Functional Theory (DFT) analysis of magnetite containing more than three iron atoms in the cluster, an essential proposition as magnetite contains three distinct iron species. These calculations were used to support the experimental observations, and closely reproduced both the experimental IR spectrum, and the XRD pattern. In vitro cytotoxicity assays showed dose responsive behavior for the nanoparticles, and demonstrated that they are non-toxic at clinically relevant concentrations; below 200 µg/mL we observed no toxicity in a 48-hour standard assay. This work represents the first DFT based simulation of this detailed magnetite cluster, and demonstrates that this sustainable synthetic method is capable of producing nanomaterials with a physical and biological profile that might make them suitable for biomedical applications.

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Multifunctional superparamagnetic iron oxide nanoparticles: Promising tools in cancer theranostics

Cited by 210 publications

References 74 publications

Preparation and in vitro antitumor effects of cytosine arabinoside-loaded genipin-poly-L-glutamic acid-modified bacterial magnetosomes

Preparation and in vitro antitumor effects of cytosine arabinoside-loaded genipin-poly-L-glutamic acid-modified bacterial magnetosomes

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Importance of the Inter-Electrode Distance for the Electrochemical Synthesis of Magnetite Nanoparticles: Synthesis, Characterization, Computational Modelling, and Cytotoxicity

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Multifunctional superparamagnetic iron oxide nanoparticles: Promising tools in cancer theranostics

Cited by 210 publications

References 74 publications

Preparation and in vitro antitumor effects of&nbsp;cytosine arabinoside-loaded genipin-poly-L-glutamic acid-modified bacterial magnetosomes

Preparation and in vitro antitumor effects of&nbsp;cytosine arabinoside-loaded genipin-poly-L-glutamic acid-modified bacterial magnetosomes

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Importance of the Inter-Electrode Distance for the Electrochemical Synthesis of Magnetite Nanoparticles: Synthesis, Characterization, Computational Modelling, and Cytotoxicity

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Product

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Preparation and in vitro antitumor effects of cytosine arabinoside-loaded genipin-poly-L-glutamic acid-modified bacterial magnetosomes

Preparation and in vitro antitumor effects of cytosine arabinoside-loaded genipin-poly-L-glutamic acid-modified bacterial magnetosomes