Multiple Cutaneous Granular Cell Tumors in Children

Abstract

Multiple cutaneous granular cell tumors are rare in childhood. We cared for two children with 15 and 6 tumors respectively. The tumors were asymptomatic nodules in the skin. Histologically, they consisted of large cells containing granules that were positive on periodic acid-Schiff stain and diastase resistant.

Multiple granular cell tumors in a child with growth retardation. Report of a case and review of the literature

“…They are usually less than 3 cm in diameter, with a smooth or hyperkeratotic surface. Multiple lesions are estimated to occur in up to 25% of cases, 1,4,6,7 but are rare in childhood 3,9–12 . In 1990, Martin et al .…”

“…Granular cell tumor (GCT) is an uncommon benign neoplasm, most likely from Schwann cell origin. It typically occurs as a solitary, painless nodule of cutaneous and subcutaneous tissues (43%), tongue (23%) or at any other anatomical site 1–4 . They can affect persons of any age, race or sex, but are more common between the third and fifth decades of life, 2 in women 1,5,6 and in the Black population 1,6,7 .…”

“…They have not been reported in children 8 . Multiple lesions have been reported in 5–25% of cases, 1,4,6,7 but are infrequent in childhood 3,9–12 . Familial occurrence has been described in patients with multiple GCTs, suggesting that some patients may have a hereditary susceptibility 13 …”

Multiple Granular Cell Tumors and Growth Hormone Deficiency in a Child

“…The occurrence of multiple granular cell tumors in children, however, is rare (9)(10)(11)(12)(13)(14)(15) and has been found to be associated with alterations in other organs in a number of cases. Several reports provide evidence for an association between multiple cutaneous granular cell tumors in childhood and neurofibromatosis (3,16).…”

Neurogenic Tumors of Soft Tissue

“…As in adults, a subset of patients present during childhood with multiple lesions or a family history of GCT [360,[372][373][374][375][376][377][378]. Associations between multiple cutaneous GCT and malformations or systemic defects (lentiginosis, craniofacial and musculoskeletal defects, cardiovascular abnormalities, and neuropathic deficits) are rare and may represent a specific neuro-cardio-facialcutaneous syndrome [379][380][381][382].…”