Multiple cutaneous metastases of neuroendocrine carcinoma derived from the uterine cervix

Lee, Won Jae; Dw, Lee; Mw, Lee; Jh, Choi; Kc, Moon; Jk, Koh

doi:10.1111/j.1468-3083.2008.02955.x

Cited by 7 publications

(1 citation statement)

References 7 publications

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“…Further rare cutaneous metastases originate from uterine leiomyosarcoma, endometrial or papillary serous cancer of the uterus, squamous cell carcinoma, and neuroendocrine carcinoma of the cervix and the vulva (82–85). Cervical carcinoma is still one of the most common malignancies in women.…”

Section: Urogenital Originmentioning

confidence: 99%

Cutaneous metastases from internal malignancies

Nashan

Meiß

Braun‐Falco

et al. 2010

Dermatologic Therapy

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Cutaneous metastases of internal malignancies still seem to occur infrequently, although medical publications report an incidence rate of up to 10.4%. Common sense, however, fosters suspicion that we might underdiagnose the problem distracted by harder striking facets of an advanced disease. With contemporary knowledge, morphology and behavior of cutaneous metastases resemble each other regardless of the site of origin. This article itemizes clinical presentations according to organ systems, specific features, and differential diagnoses. In general, the survival turned out to be less than 12 months. But incremental awareness of cutaneous metastases proclaims this paradigm insufficient. Although excision is the local treatment of choice, investigations attempt to propose tumor-specific chemotherapeutic/immunological approaches. This paper endeavors to critically review the state of the art concerning the clinic, prognosis, and therapeutic concepts.

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Section: Urogenital Originmentioning

confidence: 99%

Cutaneous metastases from internal malignancies

Nashan

Meiß

Braun‐Falco

et al. 2010

Dermatologic Therapy

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Cutaneous metastases from neuroendocrine carcinoma of the cervix—An unusual metastatic lesion from an uncommon malignancy

Devnani

Kumar

Pathy

et al. 2018

Current Problems in Cancer

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Cutaneous Metastases: A Study of 78 Biopsies From 69 patients

Fernández-Flores¹

2010

The American Journal of Dermatopathology

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A retrospective study of all cases of cutaneous metastases received in the Department of Pathology during the last 13 years was performed. Seventy-eight cases from 69 patients were examined. The majority of the patients were between 60 and 80 years of age. The most frequent anatomical location for the metastases was the abdomen. Regarding the primary tumor, breast carcinoma was the most common. In females breast carcinoma was the most common, while lymphomas predominated in males. In 14 patients (17.95%), the origin of the primary tumor was unknown. In all these cases, there was no clinical suspicion of metastasis. Epidermotropism was found in only 9 out of 78 cases (11.54%). Contrary to this, vascular invasion was a common feature, being present in 49 out of 78 cases (62.82%). Necrosis was evident in 38 cases (48.72%), but it was either moderate or prominent only in 8 cases (10.26%). Inflammatory infiltrate was absent in 3 cases (3.85%), mild in 49 (62.82%), moderate in 20 (25.64%), and prominent (graded either 3 of 4 or 4 out of 4) in 5 cases (6.41%). The metastases involved exclusively the dermis in 26 cases (33.33%), hypodermis in 7 cases (8.97%), and dermis and hypodermis in 44 cases (56.41%). We concluded that vascular invasion is a common feature in cutaneous metastases, especially in nonhematologic neoplasms, and because sometimes is focal, it should be carefully searched.

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Multiple cutaneous metastases of neuroendocrine carcinoma derived from the uterine cervix

Cited by 7 publications

References 7 publications

Cutaneous metastases from internal malignancies

Cutaneous metastases from internal malignancies

Cutaneous metastases from neuroendocrine carcinoma of the cervix—An unusual metastatic lesion from an uncommon malignancy

Cutaneous Metastases: A Study of 78 Biopsies From 69 patients

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