Multiple Factors Related to the Secretion of Glucagon-Like Peptide-1

Wang, Xingchun; Liu, Huan; Chen, Jiaqi; Li, Yan; Qu, Shen

doi:10.1155/2015/651757

Cited by 46 publications

(39 citation statements)

References 114 publications

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“…A previous study conducted on the same group of chickens showed that in ovo treatment with synbiotics caused lower total lipid content in breast muscles of 42-day-old chickens; however, this effect was significant in the case of S2 injection [15]. Moreover, SCFAs are also implicated in the regulation of blood glucose levels by increasing insulin secretion and decreasing the production of glucagon in response to SCFA-induced GLP-1 secretion [31,34]. The results of the current study revealed a trend toward lower plasma glucose and higher insulin levels on day 7 in birds from both experimental groups; however, these values did not reach statistical significance.…”

Section: Discussionmentioning

confidence: 98%

Metabolic Gene Expression in the Muscle and Blood Parameters of Broiler Chickens Stimulated In Ovo with Synbiotics

Dunisławska

Siwek

Sławińska

et al. 2020

Animals

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Simple Summary: Poultry production plays a major role in providing meat products to global markets. Hence, there is a continued interest of researchers in the possibilities of improving the production parameters of broiler chickens. A direct response from muscles and their metabolism to in ovo synbiotic stimulation on day 12 of egg incubation has already been widely documented. However, it is necessary to analyze the molecular mechanisms determining the phenotypic effects. The present research aimed to explain the molecular background of the quality of broiler chicken meat after injection of synbiotics based on Lactobacillus strains into the air chamber of the egg. Characterization of the meat quality is based on the signature of the metabolic gene expression closely related to muscles and basic physiological parameters. Abstract:To better understand the effects of synbiotics administered at early stages of embryonic development in poultry, it is necessary to analyze direct effects (meat quality) and the molecular background. The molecular interpretation of poultry meat properties after in ovo administration of synbiotics remains to be reported. The purpose of the present study was to analyze the molecular background of meat quality based on gene expression and basic physiological parameters. Eggs were injected with (S1) Lactobacillus salivarius with galacto-oligosaccharides or (S2) Lactobacillus plantarum with raffinose family oligosaccharides. The pectoral muscle was collected at two time points (day 7 and day 42) and subjected to RNA isolation. Gene expression analysis was performed by RT-qPCR for a panel of eight genes associated with metabolism. The concentration of glucose and hormones (insulin, glucagon, and leptin (S1 p = 0.04)) was also increased. The obtained results showed that metabolic gene expression in the muscle was more differential due to synbiotic stimulation on day 7 (FST in S1 p = 0.03; PDK4 in S1 p = 0.02 and S2 p = 0.01; CEBPB in S1 p = 0.01 and S2 p = 0.008; PHKB in S1 p = 0.01; PRKAG3 in S1 p = 0.02) than on day 42 (PDK4 in S1 p = 0.04). On the basis of the results obtained, it can be concluded that in ovo stimulation with S1 triggered the most potent and favorable changes in the pectoral muscle gene expression in broiler chickens. Author Contributions: Conceptualization, A.D., M.S.; methodology, A.D; formal analysis, A.D., A.S.; investigation, A.D.; resources, M.S., data curation, A.D., A.L., A.H., P.A.K.; writing-original draft preparation, A.D., A.L., A.H.; writing-review and editing, M.S., A.S.; visualization, A.D.; supervision, M.B., M.S., project administration, M.B., funding acquisition, M.B., A.D. All authors have read and agreed to the published version of the manuscript.

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Section: Discussionmentioning

confidence: 98%

Metabolic Gene Expression in the Muscle and Blood Parameters of Broiler Chickens Stimulated In Ovo with Synbiotics

Dunisławska

Siwek

Sławińska

et al. 2020

Animals

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“…The incretin hormone, GLP-1 released from the enteroendocrine L-cells of the intestine, stimulates the release of insulin from β-cells through distinct G-protein-coupled receptors highly expressed on the cells (Mignone, Wu, Horowitz, & Rayner, 2015). GLP-1 is rapidly degraded by DPP-IV, an ubiquitous enzyme expressed on the surface of most cell types (Green, Gault, O'Harte, & Flatt, 2004 (Wang, Liu, Chen, Li, & Qu, 2015).…”

Section: Effect Of Salmon-derived Hydrolysates On Glp-1 Release From mentioning

confidence: 99%

Atlantic salmon (Salmo salar) co-product-derived protein hydrolysates: A source of antidiabetic peptides

Harnedy

Parthsarathy²,

McLaughlin³

et al. 2018

Food Research International

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Large quantities of low-value protein rich co-products, such as salmon skin and trimmings, are generated annually. These co-products can be upgraded to high-value functional ingredients. The aim of this study was to assess the antidiabetic potential of salmon skin gelatin and trimmings-derived protein hydrolysates in vitro. The gelatin hydrolysate generated with Alcalase 2.4L and Flavourzyme 500L exhibited significantly higher (p < 0.001) insulin and GLP-1 secretory activity from pancreatic BRIN-BD11 and enteroendocrine GLUTag cells, respectively, when tested at 2.5 mg/mL compared to hydrolysates generated with Alcalase 2.4L or Promod 144MG. The gelatin hydrolysate generated with Alcalase 2.4L and Flavourzyme 500L showed significantly more potent (p < 0.01) DPP-IV inhibitory activity than those generated with Alcalase 2.4L or Promod 144MG. No significant difference was observed in the insulinotropic activity mediated by any of the trimmings-derived hydrolysates when tested at 2.5 mg/mL. However, the trimmings hydrolysate generated with Alcalase 2.4L and Flavourzyme 500L exhibited significantly higher DPP-IV inhibitory (p < 0.05:Alcalase 2.4L and p < 0.01:Promod 144MG) and GLP-1 (p < 0.001, 2.5 mg/mL) secretory activity than those generated with Alcalase 2.4L or Promod 144MG. The salmon trimmings hydrolysate generated with Alcalase 2.4L and Flavourzyme 500L when subjected to simulated gastrointestinal digestion (SGID) was shown to retain its GLP-1 secretory and DPP-IV inhibitory activities, in addition to improving its insulin secretory activity. However, the gelatin hydrolysate generated with Alcalase 2.4L and Flavourzyme 500L was shown to lose GLP-1 secretory activity following SGID. A significant increase in membrane potential (p < 0.001) and intracellular calcium (p < 0.001) by both co-product hydrolysates generated with Alcalase 2.4L and Flavourzyme 500L suggest that both hydrolysates mediate their insulinotropic activity through the K channel-dependent pathway. Additionally, by stimulating a significant increase in intracellular cAMP release (p < 0.05) it is likely that the trimmings-derived hydrolysate may also mediate insulin secretion through the protein kinase A pathway. The results presented herein demonstrate that salmon co-product hydrolysates exhibit promising in vitro antidiabetic activity.

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“…TGR5 локалізується на клітинах нейронів міжм'язового сплетення кишечника, L-клітинах кишечника, печінки й спинного мозку. За допомогою L-клітин УДХК стимулює секрецію глюкагоноподібного пептиду-1 (glucagon-like peptide-1, GLP-1) і нормалізує секрецію інсуліну [20,21].…”

Section: ключові слова: ожиріння; гастроезофагеальна рефлюксна хворобunclassified

Клиническая Эффективность Урсодезоксихолевой Кислоты В Комплексном Лечении Больных Ожирением И Гастроэзофагеальной Рефлюксной Болезнью

Sirchak¹

2021

GASTRO

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Патологія верхніх відділів травного каналу / Pathology of Upper Gastrointestinal Tract Оригінальні дослідження Original Researches Вступ Ожиріння-це захворювання, що глобально поширене в усьому світі, причому кількість пацієнтів з ожирінням неухильно зростає, особливо в промислово розвинених країнах [1]. За даними Всесвітньої організації охорони здоров'я (ВООЗ), понад 1,9 мільярда дорослих людей у світі мають надлишкову вагу, з них понад 600 мільйонів страждають від ожиріння [2], а до 2025 р. від ожиріння страждатимуть до 40-50 % населення планети [3]. Нині ожиріння-це не тільки медична, а й соціальна проблема [4], що обумовлено значним підвищенням ризику серйозних ускладнень, які виникають на фоні ожиріння й призводять до погіршення якості життя й передчасної смерті пацієнтів [5].

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Multiple Factors Related to the Secretion of Glucagon-Like Peptide-1

Cited by 46 publications

References 114 publications

Metabolic Gene Expression in the Muscle and Blood Parameters of Broiler Chickens Stimulated In Ovo with Synbiotics

Metabolic Gene Expression in the Muscle and Blood Parameters of Broiler Chickens Stimulated In Ovo with Synbiotics

Atlantic salmon (Salmo salar) co-product-derived protein hydrolysates: A source of antidiabetic peptides

Клиническая Эффективность Урсодезоксихолевой Кислоты В Комплексном Лечении Больных Ожирением И Гастроэзофагеальной Рефлюксной Болезнью

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