Multiple Tumors of the Brain of Diverse Origin

Myerson, Paul

doi:10.1097/00005072-194210000-00005

Cited by 44 publications

(10 citation statements)

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“…Alexander11 proposed that residual embryonic structures form the basis for the development of subsequent multiple brain tumours. Some authors held carcinogenic stimuli responsible for the simultaneous development of different brain tumours12 and other attributed it as entirely coincidental 13…”

Section: Discussionmentioning

confidence: 99%

Craniopharyngioma and epidermoid tumour in same child: a rare association

Singh

Parihar

et al. 2013

BMJ Case Reports

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SUMMARYSimultaneous occurrence of histologically different primary brain tumours is rare, and its preoperative diagnosis is still challenging. The explanations for the simultaneous occurrence of different primary intracranial tumours in the absence of phacomatoses or prior radiation exposure are at present hypothetical, and these tumours could be simply coincidental. Herein, we report a case of a boy presenting with features of raised intracranial pressure and right-sided sensorineural hearing loss. Brain MRI revealed two different neoplastic pathologies at different sites: an intrasellar and suprasellar craniopharyngioma and a right cerebellopontine angle epidermoid. To the best of our knowledge, this is the first report in literature of a craniopharyngioma coexisting with an epidermoid, in the same individual. BACKGROUND

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Section: Discussionmentioning

confidence: 99%

Craniopharyngioma and epidermoid tumour in same child: a rare association

Singh

Parihar

et al. 2013

BMJ Case Reports

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“…Based upon the Cohnheim theory of embryonic rests, Ostertag in 1941 33,34 proposed that tumors grew from primitive cells that were displaced during embryogenesis and the development of the central nervous system. These cells, when in the presence of multipotent cells, had a propensity to multiply with blastomatous potential, phenotypically presenting in later life to develop into coordinated "blastomas" throughout the nervous system.…”

Section: Discussionmentioning

confidence: 99%

Simultaneous choroid plexus carcinoma and pilocytic astrocytoma in a pediatric patient

Karami

Poulik²,

Rabah³

et al. 2010

PED

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Simultaneous primary brain tumors in pediatric patients without prior chemotherapy or radiotherapy, phacomatosis, or known familial history are a rare occurrence. The authors report the case of a 4-year-old boy with simultaneous choroid plexus carcinoma and pilocytic astrocytoma with features of oligodendroglioma. Magnetic resonance imaging studies revealed diffuse heterogeneously enhancing left intraventricular and posterior fossa tumors initially believed most consistent with multicentric choroid plexus carcinomas. A multiple staged resection was carried out for each tumor and gross-total resection was achieved. Upon gross inspection intraoperatively as well as postoperative histological analysis, 2 distinct simultaneous tumors were identified: choroid plexus carcinoma and pilocytic astrocytoma. To the authors' knowledge this is the first case report published identifying 2 distinct tumor types with similar radiological appearances in a pediatric patient with no prior history of radiotherapy, chemotherapy, or phacomatosis.

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“…[11] Although it has been suggested in the past that the presence of residual embryonic structures could subsequently become the basis for multiple tumors, this hypothesis may not be relevant any more. [12] The reasons for the simultaneous occurrence of different…”

Section: Discussionmentioning

confidence: 99%

Three distinct co-existent primary brain tumors in a patient

Iyer¹,

Sanghvi²,

Shenoy³

et al. 2009

J Can Res Ther

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A rare case of simultaneous occurrence of three entirely distinct intracranial tumors is described. A 55-year-old male with no evidence of phacomatoses or history of radiation therapy presented with complaints of increased drowsiness, headaches, and dysarthria. Investigations revealed an olfactory groove meningioma, a glioblastoma multiforme in the left medial temporal lobe, and a diffuse glioma in the brain stem. Occurrence of multiple varieties of tumors at the same time is extremely rare. Theories that explain their occurrences including the role of common carcinogens, autocrine growth factors, and tumor suppressor genes are discussed.

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Multiple Tumors of the Brain of Diverse Origin

Cited by 44 publications

References 0 publications

Craniopharyngioma and epidermoid tumour in same child: a rare association

Craniopharyngioma and epidermoid tumour in same child: a rare association

Simultaneous choroid plexus carcinoma and pilocytic astrocytoma in a pediatric patient

Three distinct co-existent primary brain tumors in a patient

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