Multiplexing technology for in vitro diagnosis of pathogens: the key contribution of phosphorus dendrimers

Majoral, Jean Pierre; François, Jean; Fabre, Richard; Senescau, Alice; Mignani, Serge; Caminade, Anne‐Marie

doi:10.1007/s40843-018-9253-5

Cited by 8 publications

(4 citation statements)

References 24 publications

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“…However, it should be emphasized that catalysis is only a part of the fields that benefit from the use of dendrimers. The PPH (polyphosphorhydrazone) dendrimers in particular gave birth to two start-ups, one in the field of materials, in particular biosensors for diagnosis [85,86], and one in the field of biology, in particular an antiinflammatory drug [87,88]. Thus, there is still plenty of room to expand the use of dendrimers in general, and more specifically of PPH dendrimers.…”

Section: Discussionmentioning

confidence: 99%

Selected properties of phosphorus dendrimers: green approaches to catalysis

Caminade,

Maraval

2024

Comptes Rendus. Chimie

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This review describes the synthesis of polyphosphorhydrazone (PPH) dendrimers, which are highly branched macromolecules, having a phosphorus atom at each branching point. The properties of these PPH dendrimers in the field of catalysis are then described. The review is organized to illustrate in the first part how the specificities of dendrimers could contribute to green chemistry. This concerns in particular the dendritic effect that is an increased efficiency (yield, enantioselectivity, etc.) when the size of the dendrimer increases, the recovery and reuse of the dendritic catalyst, the decreased leaching, and the entrapping of nanoparticles. In a second part, some even greener approaches of catalysis with dendrimers will be displayed, such as catalysis in water, switchable catalysis, and organocatalysis (no metal used). Different types of catalytic reactions have been studied, such as Stille, Suzuki and Sonogashira couplings, Knoevenagel condensations, Michael additions, asymmetric allylic alkylations, O-and N -arylation and vinylation reactions, [2+2+2]-cycloaddition reactions, isomerization of 1-octan-3-ol, Friedel-Crafts acylations, Heck reactions, hydrogenations, hydrations, transfer hydrogenations, amination of β-dicarbonyl compounds, etc.

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Section: Discussionmentioning

confidence: 99%

Selected properties of phosphorus dendrimers: green approaches to catalysis

Caminade,

Maraval

2024

Comptes Rendus. Chimie

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“…However, dendrimers have already found application in personalized medicine to enhance the efficiency of diagnosis tools [ 57 ]. They are used as 3D spacers in chips for bioassays between the solid surface and the probe to increase the binding efficiency of the probe.…”

Section: Discussionmentioning

confidence: 99%

Dendrimers, an Emerging Opportunity in Personalized Medicine?

Caminade

2022

JPM

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Dendrimers are highly branched macromolecules tailorable at will to fulfil precise requirements. They have generated a great many expectations and a huge number of publications and patents in relation to medicine, including in relation to personalized medicine, but have resulted in very poor clinical translation up to now. As clinical trials are the first steps in view of developing new compounds for (a personalized) medicine, this review focusses on the clinical trials carried out with dendrimers. Many of these clinical trials have been recently posted (2020–2022); thus, only very few concern phase 3. The safety and efficiency of essentially two main types of dendrimers, based on polylysine and polyamidoamide scaffolds, have been assessed up to now. These dendrimers were tested with the aim of treating mainly bacterial vaginosis, cancers, and COVID-19.

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“…This special structure makes BP-based nanoplatforms promising candidates for nanocarriers [111]. Moreover, it is well-known that the phosphorus is a vital element in organisms involving many important functions (e.g., energy transformation and the construction of nucleic acids), and thus BP nanomaterials have been proposed to have better biocompatibility and biodegradability than graphene-related materials [112][113][114][115]. Preliminary studies have demonstrated that BP can substantially decompose to nontoxic intermediates such as phosphates or phosphites.…”

Section: Xenesmentioning

confidence: 99%

Recent advance in near-infrared/ultrasound-sensitive 2D-nanomaterials for cancer therapeutics

et al. 2020

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In recent years, the emerging two-dimensional (2D) nanomaterials have shown great potential for a variety of applications such as electronics, catalysis, supercapacitors, and energy materials. In the biomedical arena, these nanomaterials, especially 2D-ultrathin nanomaterials, have also been regarded as promising nano-carriers and/or diagnostic agents for cancer diagnosis and treatment, owing to their remarkable mechanical, photothermal, and optical properties. In this review, we provide the recent development of the nanoplatforms based on near-infrared/ultrasound-sensitive 2D-materials, representatively such as graphdiyne (GDY), black phosphorus, transition metal dichalcogenides (TMDs), and antimonene, for non-invasive cancer therapeutics including photothermal, photodynamic and sonodynamic approaches. The general properties of these 2D nanomaterials linking to biomedical interests are first introduced, followed by the fabrication processes of diverse nano-platforms and related outcomes of cancer diagnosis and treatments. We also outline the current challenges and prospects of the 2D materials for non-invasive approaches to cancer treatments in the future.

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Multiplexing technology for in vitro diagnosis of pathogens: the key contribution of phosphorus dendrimers

Cited by 8 publications

References 24 publications

Selected properties of phosphorus dendrimers: green approaches to catalysis

Selected properties of phosphorus dendrimers: green approaches to catalysis

Dendrimers, an Emerging Opportunity in Personalized Medicine?

Recent advance in near-infrared/ultrasound-sensitive 2D-nanomaterials for cancer therapeutics

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