“…The design of multi‐product batch plants using an optimization‐based approach has been studied for more than 40 years and different approaches to deal with the complexity of the optimization models that result in non‐convex mixed‐integer non‐linear problems (MINLP) goes from the development of new algorithms that are able solve these type of problems (Borisenko et al, ; Kocis and Grossmann, ; Li et al, ; Viswanathan and Grossmann, ) to the reformulation of them into mixed‐integer linear problems (MILP) (Moreno and Montagna, ; Sandoval et al, ; Voudouris and Grossmann, ) that can be solved using the known accurate commercial solver CPLEX. In the majority of the cases, the aim of these efforts is to be able to find the optimal design of multi‐product batch plants in real scenarios which is, according to Barbosa‐Póvoa (), still a challenge.…”