Muscle ATP Content in Rheumatoid Arthritis - a Biopsy Study

In 10 children with delayed walking, muscle specimens were obtained by needle biopsy from the vastus lateralis muscle for determination of ATP, creatine phosphate (CP), glycogen and lactate concentration, as well as fibre composition and fibre size. The values obtained are compared with corresponding results for a control group of 25 children aged 2 months--11 years. Details of the control series are given and its validity as a reference group is discussed. Six children (group I) who showed minor gross motor delay but otherwise normal development at follow-up were found to have lowered ATP, CP and glycogen concentrations, compared to 4 children (group II) who had general developmental delay, and to the control group. The children in group I were shown to have smaller fibre size and a greater difference between type 1 and 2 fibres than the children in group II and in the control group. No differences in the concentrations of metabolic substrates or the morphometric values could be detected between group II and the control group.

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Metabolic substrates, muscle fibre composition and fibre size in late walking and normal children

Lundberg

Eriksson

Mellgren

1979

Eur J Pediatr

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Electron probe X-ray microanalysis of human skeletal muscle involved in rheumatoid arthritis

et al. 1978

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Electron probe X-ray microanalysis in the scanning microscope was used to determine the elemental composition of muscle fibres from patients with rheumatoid arthritis (RA). Quantitative data concerning phosphorus, sulphur, chlorine and potassium were correlated to the fibre type by a routine method based on serial cryosectioning and histochemical staining of adjacent sections. Significantly lowered sulphur values were found in type II A and II B muscle fibres of RA patients as compared to those of healthy controls. Traces of gold were detected in muscles of two patients treated with gold salts. The basis and mechanism for the decreased sulphur content in RA muscles are so far unknown, but may depend on the decreased amount of sulphur-rich potein(s).

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Intraarticular corticosteroid injection into rheumatoid arthritis knees improves extensor muscles strength

et al. 1990

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Eleven arthritic knee joints in seven patients with rheumatoid arthritis were studied before and after intraarticular injection of a corticosteroid preparation. Extensor muscle torque and quantitative electromyography increased on days 7 and 14 after treatment, indicating that muscle function had been inhibited by synovitis. Clinical signs of synovitis, such as pain, range of motion and knee circumference, also improved. Synovial fluid withdrawal alone improved extensor muscle torque. Joints with instability and/or radiological cartilage involvement also improved.

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Muscle ATP Content in Rheumatoid Arthritis - a Biopsy Study

Cited by 11 publications

References 10 publications

Metabolic substrates, muscle fibre composition and fibre size in late walking and normal children

Metabolic substrates, muscle fibre composition and fibre size in late walking and normal children

Electron probe X-ray microanalysis of human skeletal muscle involved in rheumatoid arthritis

Intraarticular corticosteroid injection into rheumatoid arthritis knees improves extensor muscles strength

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