Muscle damage is linked to cytokine changes following a 160-km race

Nieman, David C.; Dumke, Charles L.; Henson, Dru A.; McAnulty, Steven R.; Gross, Sarah J.; Lind, Robert H.

doi:10.1016/j.bbi.2005.03.008

Cited by 156 publications

(141 citation statements)

References 20 publications

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“…Creatine phosphokinase (CPK) and lactate dehydrogenase (LDH) are among the most investigated markers of muscle damage (Kim et al, 2007). The increase in CPK arising from exercise is directly related to the appearance of Delayed Onset Muscle Soreness (DOMS) (Nieman et al, 2005) as well as increased expression of markers for cartilage injury (Kim et al, 2007). Moreover, the increase in serum concentrations of CPK after exercise is inversely proportional to the ability of muscle to produce force (Skurvydas et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Cryotherapy post-training reduces muscle damage markers in jiu-jitsu fighters

Santos¹,

Brito²,

Júnior³

et al. 2012

JHSE

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Santos WOC, Brito CJ, Júnior EAP, Valido CN, Mendes EL, Nunes MAP, Franchini E. Cryotherapy posttraining reduces muscle damage markers in jiu-jitsu fighters. J. Hum. Sport Exerc. Vol. 7, No. 3, pp. 629-638, 2012. Although widely used in sports, the efficiency of cryotherapy in reducing muscle damage has been questioned. The present study investigated the acute effects of post-exercise cryotherapy on the expression of creatine phosphokinase (CPK) and lactate dehydrogenase (LDH), perceived pain, and muscle strength of the upper limbs in Brazilian jiu-jitsu competitors. Nine highly trained fighters were subjected to two 90-minute training sessions. After the first session, five random subjects were immersed in a pool with ice (5±1°C) for nineteen minutes, and the remaining participants were allocated to the control group. The treatments were reversed in the second session (cross-over design). Analysis of covariance with repeated measures was used to compare outcomes between the groups, and pre-test measures were used as covariates. Pearson's correlation was adopted to check the strength of the associations between variables. The results showed lower serum CPK concentrations (P<0.05) in the cryotherapy group (504.0±138.7 IU/L) compared to the pre-exercise (532.6 ± 67.9 IU/L) group, and a similar result was observed for LDH (517.4±190.3 vs. 601.8±75.7 IU/L). Cryotherapy resulted in lower (P<0.05) perceived pain (2.2 ± 1.6 vs. 4.2 ± 1.9) and body temperature (34.2±1.3°C vs. 36.3±0.7°C), and an attenuated loss of isometric strength (53.1±18.1 s vs. 42.9±14.5 s). Perceived pain was directly associated (P<0.05) with CPK (r=0.59) and LDH (r=0.475) levels. The results show that post-exercise cryotherapy resulted in lower serum CPK and LDH, hypoalgesia, and greater preservation of isometric strength endurance when compared to the control condition.

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Section: Introductionmentioning

confidence: 99%

Cryotherapy post-training reduces muscle damage markers in jiu-jitsu fighters

Santos¹,

Brito²,

Júnior³

et al. 2012

JHSE

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“…Nieman and colleagues [32], in a comparative study among non steroidal anti-inflammatory (NSAID) users and nonusers, did not reveal any differences in CK or level of muscle soreness. However, the study unexpectedly showed two to three times greater rise in five of seven cytokines in the NSAID (primarily ibuprofen) users.…”

Section: Ultra Endurance Exercisementioning

confidence: 99%

“…In addition, subsequent investigations would clarify whether, after ultra endurance exercise, anti-inflammatory cytokines are generated chiefly in response to muscle damage or other factors [33]. Moreover, all of the above clinical trials included a small sample size [30 -33] with a maximum of sixty athletes in only one of them [32]. Also, additional studies of long follow up are needed.…”

Section: Limitations/implications For Further Researchmentioning

confidence: 99%

“…Future research could specify whether NSAID use augments cytokine reactions following ultramarathons through an endotoxaemia pathway. Secondly, in view of the fact that there is no beneficial effect of NSAIDS in alleviating muscle soreness and damage after contraction-induced muscle injury [32], a question that is raised is whether there are any safe and effective nutritional, classical homoeopathic, or herbal substances that can be used before, during or after ultraendurance exercise to lessen this type of inflammatory response aiding healing and enhancing physical performance. In addition, subsequent investigations would clarify whether, after ultra endurance exercise, anti-inflammatory cytokines are generated chiefly in response to muscle damage or other factors [33].…”

Section: Limitations/implications For Further Researchmentioning

confidence: 99%

“…Also, additional studies of long follow up are needed. Lastly, new clinical trials recruiting equal number of male and female participants are necessary since three studies involved only male participants [30,31,33], and only one engaged both sexes [32].…”

Section: Limitations/implications For Further Researchmentioning

confidence: 99%

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Lifestyle Factors that can Induce an Independent and Persistent Low-Grade Systemic Inflammatory Response: A Wholistic Approach

Vrousgos¹

2016

MEDJ

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Abstract:Subclinical inflammation was first shown in numerous chronic medical illnesses and in the early 1900s, activation of immune-inflammatory pathways was initially observed in a lifestyle-related disorder such as depression. A chronic mild inflammatory state is also a key feature of obesity as well as insulin resistance and other metabolic diseases. This particular form of immune process has given rise to the concept of "metaflammation" (metabolically triggered inflammation) because it can target vital organs and tissues that are critical for the regulation of metabolism, and ultimately disrupt systemic homoeostasis with detrimental health effects. However, accumulating evidence demonstrates a link between metaflammation and a number of lifestyle factors. Lifestyle variables such as ultra-endurance exercise, physical inactivity, extremes of sleep duration, cigarette smoking, burnout, anxiety, and depression can activate multiple immune-inflammatory pathways. Therefore, this review of the literature that bears hallmarks of a systematic review investigates and presents published research data of these lifestyle factors that can induce an independent and persistent low-grade systemic inflammatory response, within the human body, evaluated through the measurement of various biomarkers.

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Simultaneous quantification of 19 nonsteroidal anti‐inflammatory drugs in oral fluid by liquid chromatography‐high resolution mass spectrometry: Application on ultratrail runner's oral fluid

Mashal

Nalin

Bévalot

et al. 2022

Drug Testing and Analysis

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Nonsteroidal anti-inflammatory drugs (NSAIDs) are a therapeutic class suspected to be used by ultratrail runners. The use of NSAIDs during ultratrails is known to be associated with various adverse effects. To study the prevalence of NSAIDs intake in ultratrail runners, oral fluid (OF) is a relevant matrix as it is noninvasive and easy to collect. The aim of our work was to develop and validate a liquid-liquid extraction followed by a liquid chromatography (LC)-mass spectrometry (MS)/high resolution mass spectrometry (HRMS) method for the simultaneous quantification of 19 NSAIDs in OF. After a comparison of different liquid-liquid extraction methods, a double step liquid-liquid extraction with chloroform was performed on OF collected with Quantisal ® , with extraction recoveries higher than 90%. An Accucore AQ column

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Muscle damage is linked to cytokine changes following a 160-km race

Cited by 156 publications

References 20 publications

Cryotherapy post-training reduces muscle damage markers in jiu-jitsu fighters

Cryotherapy post-training reduces muscle damage markers in jiu-jitsu fighters

Lifestyle Factors that can Induce an Independent and Persistent Low-Grade Systemic Inflammatory Response: A Wholistic Approach

Simultaneous quantification of 19 nonsteroidal anti‐inflammatory drugs in oral fluid by liquid chromatography‐high resolution mass spectrometry: Application on ultratrail runner's oral fluid

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