Muscle metastasis of carcinoma

Molina‐Garrido, María‐José; Guillén‐Ponce, Carmen

doi:10.1007/s12094-011-0625-x

Cited by 37 publications

(38 citation statements)

References 31 publications

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“…8 In case of painful isolated mass, surgery is the treatment of choice. 1 As our patient had a painless lump so with the valuable opinion of the tumor board, we treated our patients with chemotherapy and con rmed a partial response. We recommend further studies for the prognosis, proper diagnostic and therapeutic strategies for skeletal muscle metastasis in breast cancer.…”

Section: Figure-2: DI Use Scattered Neoplastic Cells With Distractionmentioning

confidence: 73%

“…Factors that make skeletal muscle hostile include muscle motion resulting in mechanical tumor destruction, inhospitable muscle pH, the muscle's ability to remove tumor-produced lactic acid associated with angiogenesis, and the activation of lymphocytes and natural killer cells in skeletal muscle. 1,2 However, skeletal muscle metastasis from breast cancer is also a very uncommon presentation and is often manifested as disseminated disease with multiple organ metastasis. 3 Only 15 cases have been reported so far upto our knowledge.…”

Section: Discussionmentioning

confidence: 99%

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Abdominal wall metastasis of carcinoma breast : a case report

et al. 2016

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Case PresentationA 30 years old lady was referred from the medical college hospital after being done the Modi ed Radical Mastectomy of left side as she was a diagnosed case of carcinoma of left breast with left sided axillary lymphadenopathy due to metastatic deposits. Immunohistochemistry studies showed receptor status of tumor is triple negative. e cause of referral was to execute adjuvant therapy. Accordingly she underwent 6 cycle chemotherapy with AC, QW and paclitaxel drug and subsequently 25 cycle radiotherapy. In each visit she was given follow up with tumor marker, baseline blood biochemistry and upper abdominal ultrasound. Upto the 15 months postoperatively her outcome was uneventful. ereafter she noticed a nodular swelling in her right upper abdomen which was rapidly growing in size. With this complaints with no other feature of metastasis she was admitted into National Institute of Cancer Research & Hospital (NICRH). Her physical examination revealed a 2x2 cm non-tender lump, normal temperature, irregular surface, ill-de ned margin, rm to hard in consistency, xed with overlying skin and underlying skeletal muscle.e lump was non-compressible and non-reducible. We found 2 very small nodular swelling in the upper outer quadrant of her right breast, measuring about 0.5x0.5 cm along with two axillary lymph nodes of medial group in right side, largest one measuring 1x0.5 cm. Diagnostic work up including complete blood count, blood biochemistry and tumor marker CA 15-3 was done. Accordingly we found, raised ESR with mild neutrophilic leucocytosis; liver function and renal function tests were normal. Tumor marker was also normal. Ultrasonography of abdomen showed a parietal wall mass originating from the skeletal muscles and involved skin; the size and site was almost corresponding to the clinical ndings. Sonography of her right breast found suspicious nodule but the right axilla found multiple lymph node enlargement of which two were larger in size. Upper abdominal CT scan showed a parietal lump (2.5x2 cm, isodense to muscle) in the right anterior abdominal wall involving the skin to external oblique muscle. (Figure-1)

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Section: Figure-2: DI Use Scattered Neoplastic Cells With Distractionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Abdominal wall metastasis of carcinoma breast : a case report

et al. 2016

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“…On immunohistochemical staining, IMM cells stain positively for vimentin, and variably for CD34 and actin; immunostain for S-100 protein is typically negative, unlike in myxoid liposarcoma and neurothekeoma (nerve sheath myxoma) (30). As the metastatic lesion is transferred hematogenously, it will show malignant characteristics, such as mitosis, nuclear atypia, necrosis and specific immunohistochemical results corresponding with the primary tumor site (31). In the present study, a rather rare lesion, namely an IMM, was unexpectedly found in the psoas, with left lung squamous cell carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Non-small cell lung cancer with concomitant intramuscular myxoma of the right psoas mimicking intramuscular metastasis: A case report and literature review

et al. 2015

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Abstract. Intramuscular myxoma (IMM) as a rare soft-tissue tumor arising from the muscles is completely benign. When IMM accompanies malignance, it may be misdiagnosed as muscle metastasis, and for this extremely rare concurrence, the subsequent treatment would vary accordingly. The current study presents, to the best of our knowledge, the first case of non-small cell lung cancer (NSCLC) concomitant with IMM mimicking skeletal muscle metastasis. A 64-year-old female was hospitalized with a history of chest discomfort and right lumbar pain that had persisted for four months. The computed tomography scan showed a lesion in the left upper lobe of the lung and the right psoas, respectively. Serum biomarkers for NSCLC were abnormal. A presumptive clinical diagnosis was compatible with left NSCLC and right psoas muscle metastasis (cT2aN3M1b, stage Ⅳ). Stage Ⅳ lung cancer would receive palliative treatment. However, the final diagnosis of synchronous left lung squamous cell carcinoma (cT2aN3M0, stage ⅢB) and IMM in the right psoas was confirmed by biopsy. The patient therefore underwent definitive chemoradiotherapy for lung carcinoma, and conservative treatment, including analgesics, for IMM. The diagnosis process for a malignant neoplasm concomitant with IMM is not straightforward due to a lack of clinical experience, and it significantly affects the tumor staging and subsequent treatment strategy. The present case suggests that IMM should be included in the differential diagnosis when an abnormal intramuscular lesion concomitant with malignancy is identified. The value of histopathological diagnosis prior to definitive treatment also requires highlighting.

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“…The commonly reported primary malignancies that may metastasize to the skeletal muscle are lung cancer, renal cell carcinoma and gastrointestinal tumours and genital tumours, but rarely melanoma [13][14][15][16][17][18][19][20][21][22] . The best epidemiological evidence for skeletal muscle metastasis reported to date was from an 8-year retrospective review of Surov et al They reported an incidence of 1.2% out of 5,170 patients that presented with metastatic solid malignancies, and most of them (91.8%) already had widespread metastases when the distal skeletal muscle was found to be invaded, hence it's uncommon to see isolated intramuscular metastases without spreading to other distant organs as in our case.…”

Section: Discussionmentioning

confidence: 99%

“…The common clinical scenario in which skeletal muscle metastasis is detected is the presenting symptom of a painful mass (usually more than 5 cm in diameter) [13][14][15][16][17][18][19][20][21][22] . This may be an important clue to suggest metastasis rather than a primary sarcoma of soft tissue, which is more commonly seen but typically present as painless soft tissue masses [14,20] .…”

Section: Discussionmentioning

confidence: 99%