1987
DOI: 10.1016/0022-510x(87)90219-x
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Muscular dystrophy in the mdx mouse: Histopathology of the soleus and extensor digitorum longus muscles

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Cited by 259 publications
(185 citation statements)
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“…It seems to be more closely related to the ability of muscle to regenerate. The necrosis and regeneration of skeletal muscle in mdx mice has been well documented [10][11][12], with acute necrosis and regeneration being most marked in hindleg muscles at 1-2 months [10]. This is accompanied by increases in protein synthesis and degradation rates in hindlimb skeletal muscles [36].…”
Section: Discussionmentioning
confidence: 99%
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“…It seems to be more closely related to the ability of muscle to regenerate. The necrosis and regeneration of skeletal muscle in mdx mice has been well documented [10][11][12], with acute necrosis and regeneration being most marked in hindleg muscles at 1-2 months [10]. This is accompanied by increases in protein synthesis and degradation rates in hindlimb skeletal muscles [36].…”
Section: Discussionmentioning
confidence: 99%
“…It is absent from the skeletal muscle of both DMD humans and mdx mice [6][7][8][9]. Although muscular dystrophies are characterized by muscle degeneration, a major difference between the mdx mouse and the DMD human syndromes is the successful muscle fibre regeneration that occurs in the mdx mice, which restores muscle histology and function to approximate normality [10][11][12]. This explains the lack of muscle weakness and the normal life-span of mdx mice.…”
Section: Introductionmentioning
confidence: 99%
“…Variations in the expression of mitochondrial genes were thus reported to be 2-to 4-fold during myogenic differentiation [30], and 1.5-to g-fold in more extreme situations such as mitochondrial myopathies [15] and cancer cells [28]. In addition, the general trend in mdx and DMD muscles of a shift towards oxidative slow-type muscle fibers [3,18,20,25], richer in mitochondrial DNA and RNA [31], partially reduces the decrease in the overall mitochondrial RNA content here. (ii) The second element is under-expression of the encoded proteins.…”
Section: Discussionmentioning
confidence: 99%
“…Although severe dystrophic changes are observed in the muscles of the diaphragm [5], the mdx mouse does not show the progressive degeneration of limb muscles characteristic of the human disease. Instead, a high level of myofibre regeneration in the limbs seems to effectively restore muscle integrity and function [6]. Nevertheless, mdx mouse skeletal muscle provides an excellent model for the early myopathic phase of DMD.…”
Section: Introductionmentioning
confidence: 99%