Musculoskeletal recovery following hindlimb immobilization in adult female rats

Maeda, Hideaki; Kimmel, Donald B.; Raab, Diane M.; Lane, Nancy E.

doi:10.1016/8756-3282(93)90242-3

Cited by 62 publications

(45 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Researchers have shown a 10-30% decrease in femoral cancellous tissue within a few weeks (up to 50% after 18 weeks) of unilateral hindlimb immobilization using an elastic band in 6-to 9-month-old female rats (Li et al, 1990;Maeda et al, 1993). Similar levels but faster bone losses (within 2-8 weeks of immobilization) have been detected with a comparable model of disuse but in younger rats (2-3 months old, Chen et al, 1992).…”

Section: Discussionmentioning

confidence: 80%

“…In animal models of disuse, traditionally in rats, hindlimb immobilization has been found to induce a drastic and sudden loss of femoral bone tissue, suggesting that dif-ferent mechanisms may be involved in disuse-related (fast bone loss) vs. age-related osteoporosis (slow bone loss; Bagi and Miller, 1994). For instance, a 10-30% (up to 50% after 18 months) decrease of cancellous bone was found within a few weeks in the ipsilateral femur of rats that had their hindlimbs immobilized with a cast or an elastic bandage (Li et al, 1990;Chen et al, 1992;Maeda et al, 1993). Some of the changes associated with disuse are believed to be mediated by both an increase of osteoclastic bone resorption and a decrease of osteoblastic bone formation (Rantakokko et al, 1999;Kingery et al, 2003).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Histomorphometric and Densitometric Changes in the Femora of Spinal Cord Transected Mice

Picard

Lapointe

Brown

et al. 2008

The Anatomical Record

View full text Add to dashboard Cite

Spinal cord injury (SCI) leads generally to significant bone tissue loss within a few months to a few years post-trauma. Although, increasing data from rat models are available to study the underlying mechanisms of SCI-associated bone loss, little is known about the extent and rapidity of bone tissue changes in mouse models of SCI. The objectives are to characterize and describe quantitatively femoral bone tissue changes during 1 month in adult paraplegic mice. Histomorphometric and densitometric measurements were performed in 3-to 4-month-old CD1 mice spinal cord transected at the low-thoracic level (Th9/10). We found a general decrease in bone volume (222%), trabecular thickness (210%), and trabecular number (214%) within 30 days post-transection. Dual-energy Xray absorptiometric measurements revealed no change in bone mineral density but a significant reduction (214%) in bone mineral content. These results show large structural changes occurring within only a few weeks post-spinal cord transection in the femora of adult mice. Given the increasing availability of genetic and molecular research tools for research in mice, this murine model may be useful to study further the cellular and molecular mechanisms of demineralization associated with SCI.

show abstract

Section: Discussionmentioning

confidence: 80%

mentioning

confidence: 99%

Histomorphometric and Densitometric Changes in the Femora of Spinal Cord Transected Mice

Picard

Lapointe

Brown

et al. 2008

The Anatomical Record

View full text Add to dashboard Cite

show abstract

“…However, when FES is employed after prolonged disuse, it is relatively ineective in reversing disuse atrophy. 30 Thus, it is not surprising that previous studies conducted in chronically paralyzed individuals have shown only moderate improvement in muscle mass. The present study showed that FES-CE could prevent disuse atrophy when training is initiated during the acute phase of muscle atrophy resulting from SCI.…”

Section: Discussionmentioning

confidence: 99%

Muscle atrophy is prevented in patients with acute spinal cord injury using functional electrical stimulation

et al. 1998

View full text Add to dashboard Cite

Severe muscle atrophy occurs rapidly following traumatic spinal cord injury (SCI). Previous research shows that neuromuscular or`functional' electrical stimulation (FES), particularly FES-cycle ergometry (FES-CE) can cause muscle hypertrophy in individuals with chronic SCI (41 year post-injury). However, the modest degree of hypertrophy in these already atrophied muscles has lessened earlier hopes that FES therapy would reduce secondary impairments of SCI. It is not known whether FES treatments are eective when used to prevent, rather than reverse, muscle atrophy in individuals with acute SCI. This study explored whether unloaded isometric FES contractions (FES-IC) or FES-CE decreased subsequent muscle atrophy in individual with acute SCI (53 months post-injury). Twenty-six subjects, 14 ± 15 weeks posttraumatic SCI, were assigned to control, FES-IC, or FES-CE against progessively increasing resistance. Subjects were involved in the study for 3 or 6 months. Total body lean body mass (TB-LBM), lower limb lean body mass (LL-LBM), and gluteal lean body mass (G-LBM) were determined before the study, and at 3 and 6 months using dual energy X-ray absorptiometry (DEXA). Controls lost an average of 6.1%, 10.1%, 12.4%, after 3 months and 9.5%, 21.4%, 26.8% after 6 months in TB-LBM, LL-LBM and G-LBM respectively. Subjects in the FES-IC group consistently lost less lean body mass than controls, however, only 6 month G-LBM loss was signi®cantly attenuated in this group relative to the controls. In the FES-CE group, LL-LBM and G-LBM loss were prevented at both 3 and 6 months, and TB-LBM loss was prevented at 6 months. In addition, FES-CE signi®cantly increased G-LBM and LL-LBM after 6 months of training relative to pre-training levels. Within the control group, there was no signi®cant relationship between LL-LBM loss (3 and 6 months) and the number of days between injury and baseline measurement. In summary, this study shows that FES-CE, but not FES-IC, training prevents muscle atrophy in acute SCI after 3 months of training, and causes signi®cant hypertrophy after 6 months. The magnitude of dierences in regionalized LBM between controls and FES-CE subject raises hopes that such treatment may indeed be bene®cial in preventing secondary impairments of SCI if employed before extensive post-injury atrophy occurs.

show abstract

“…The effects of training and detraining have therefore been studied by numerous authors. For rat models, relative short period of six weeks of remobilization following six weeks of hindlimb immobilization resulted in incomplete recovery of bone mass (Maeda et al, 1993). Longer period of 18 weeks of hindlimb immobilization followed by 20 weeks of remobilization resulted in a 34% decrease of trabecular bone area of distal tibiae.…”

Section: Introductionmentioning

confidence: 99%

Delay of intracortical bone remodelling following a stress change: A theoretical and experimental study

Terrier¹,

Miyagaki²,

Fujie³

et al. 2005

Clinical Biomechanics

View full text Add to dashboard Cite

Background. A theoretical model and an experimental setup were specifically designed to identify and determine the delay of the cortical bone response (restricted to mineralization and demineralization) to a stress change.Methods. The in vivo experiment considered two groups of rats: a running group and a control sedentary group. The running group rats were compelled to a running activity for 15 weeks, followed by a sedentary activity for 15 weeks. Bone density was derived from hardness measurements. The parameters of the remodelling theory, including the response delay and the remodelling rates, were determined from these experimental measurements.Findings. Bone density increased significantly during the activity period, and decreased rapidly when rats returned to sedentary state. The identification of the modelÕs parameters produced evolution curves that were within the limits of the standard deviation of the experimental data. The densification rate was lower than the resorption rate, and the densification delay was greater than bone resorption delay.Interpretation. The delays determined with this macroscopic model are related to response delays due to biological internal processes in bone.

show abstract

Musculoskeletal recovery following hindlimb immobilization in adult female rats

Cited by 62 publications

References 37 publications

Histomorphometric and Densitometric Changes in the Femora of Spinal Cord Transected Mice

Histomorphometric and Densitometric Changes in the Femora of Spinal Cord Transected Mice

Muscle atrophy is prevented in patients with acute spinal cord injury using functional electrical stimulation

Delay of intracortical bone remodelling following a stress change: A theoretical and experimental study

Contact Info

Product

Resources

About